Thrombospondin 1 and Its Diverse Roles as a Regulator of Extracellular Matrix in Fibrotic Disease

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Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis

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USF2 knockdown downregulates THBS1 to inhibit the TGF-β signaling pathway and reduce pyroptosis in sepsis-induced acute kidney injury

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Thrombospondin-1 CD47 Signalling: From Mechanisms to Medicine

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Thrombospondin 1 in Metabolic Diseases

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Shared and Compartment‐Specific Processes in Nucleus Pulposus and Annulus Fibrosus During Intervertebral Disc Degeneration

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TSP-1 (Thrombospondin-1) Deficiency Protects ApoE −/− Mice Against Leptin-Induced Atherosclerosis

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Counter regulation of tumor angiogenesis by vascular endothelial growth factor and thrombospondin-1

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Agonists of prostaglandin E 2 receptors as potential first in class treatment for nephronophthisis and related ciliopathies

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NF-κB activation in cardiac fibroblasts results in the recruitment of inflammatory Ly6C hi monocytes in pressure-overloaded hearts

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Myeloid-Derived TSP1 (Thrombospondin-1) Contributes to Abdominal Aortic Aneurysm Through Suppressing Tissue Inhibitor of Metalloproteinases-1

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eNAMPT Is a Novel Damage-associated Molecular Pattern Protein That Contributes to the Severity of Radiation-Induced Lung Fibrosis

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Cell–cell communication in kidney fibrosis

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Ablation of C/EBP homologous protein attenuates renal fibrosis after ureteral obstruction by reducing autophagy and microtubule disruption

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A unique esophageal extracellular matrix proteome alters normal fibroblast function in severe eosinophilic esophagitis

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Defining the versican interactome in lung health and disease

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TSP1 promotes fibroblast proliferation and extracellular matrix deposition via the IL6 / JAK2 / STAT3 signalling pathway in keloids

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Thrombospondin 1 missense alleles induce extracellular matrix protein aggregation and TM dysfunction in congenital glaucoma

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In the balance: how do thrombospondins contribute to the cellular pathophysiology of cardiovascular disease?

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Pathophysiological roles of thrombospondin-4 in disease development

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Why do humans need thrombospondin-1?

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Aesculetin Accelerates Osteoblast Differentiation and Matrix-Vesicle-Mediated Mineralization

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m6A reader IGF2BP1 facilitates macrophage glycolytic metabolism and fibrotic phenotype by stabilizing THBS1 mRNA to promote pulmonary fibrosis

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Extracellular Matrix of Echinoderms

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Controlled extracellular proteolysis of thrombospondins

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Baicalin attenuates adriamycin-induced nephrotic syndrome by regulating fibrosis procession and inflammatory reaction

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The endocytic receptor uPARAP is a regulator of extracellular thrombospondin-1

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Integrin β1/Cell Surface GRP78 Complex Regulates TGFβ1 and Its Profibrotic Effects in Response to High Glucose

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ECM-Focused Proteomic Analysis of Ear Punch Regeneration in Acomys cahirinus

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Blocking TSP1 Ameliorates Diabetes Mellitus-Induced Erectile Dysfunction by Inhibiting the TGF-β/SMAD Pathway

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Extracellular matrix ligands modulate the endothelial progenitor cell secretome for enhanced angiogenesis

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Invadopodia associated Thrombospondin-1 contributes to a post-therapy pro-invasive response in glioblastoma cells

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piRNA, the hidden player in cardiac fibrosis: A review

Li, Y., Fang, B., He, Y., Wang, Y., Wang, K., & Yang, S. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.146437 · Cited by 3

Global Proteomics Analysis of Lysophosphatidic Acid Signaling in PC-3 Human Prostate Cancer Cells: Role of CCN1

Balijepalli, P., Yue, G., Prasad, B., & Meier, K. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25042067 · Cited by 3

Design and discovery of novel cyclic peptides as TSP1-CD36 interaction inhibitors for intestinal fibrosis treatment

Zhang, W., Qi, L., Cheng, W., Wang, X., Hong, Y., Dong, R., Yuan, W., & Zhang, D. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108667 · Cited by 2

Hypomethylation of thrombospondin-1 promoter region is associated with reduced aqueous humor flow

Choy, K. Y., Yang, W.-Y., Ling, C.-Y., Li, K. K., Li, H. L., Lung, H. L., To, C. H., Wai, C., Stamer, W. D., & Shan, S. W. (2025) · Communications Biology · doi:10.1038/s42003-025-08833-y · Cited by 2

Thrombospondin-1 (THBS1) is dysregulated in preeclampsia

Botha, S. M., Bartho, L. A., Hartmann, S., Cannon, P., Nguyen, A., Nguyen, T. V., Pritchard, N., Dechend, R., Nonn, O., Tong, S., et al. (2025) · Placenta · doi:10.1016/j.placenta.2025.11.013 · Cited by 2

The dual role of thrombospondin-1 in inflammatory regulation during acute respiratory distress syndrome: a mini-review

Zheng, Y., Liu, C., Li, Y., Wang, W. Y., & Dou, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1699900 · Cited by 2

Spatially resolved single-cell analysis of transcriptomic changes linked with neuropathic pain in human neuromas

Morchio, M., Sankaranarayanan, I., Tavares‐Ferreira, D., Wong, N., Atkins, S., Sher, E., Price, T. J., Lambert, D., & Boissonade, F. M. (2026) · Pain · doi:10.1097/j.pain.0000000000003907 · Cited by 3

Hydrodistention does not alter bladder gene expression profiles in patients with non‐Hunner lesion interstitial cystitis/bladder pain syndrome

Xu, R., Schachar, J. S., Evans, R. J., Matthews, C. A., Badlani, G. H., & Walker, S. J. (2021) · Neurourology and Urodynamics · doi:10.1002/nau.24680 · Cited by 2

Integrative analysis of mRNA, lncRNA, circRNA, and miRNA to investigate the anti-fibrotic activity of silibinin in TGF-β2-treated human trabecular meshwork cells

Liu, J., Wu, X., Guo, J., Zhou, L., Liu, X., Zhu, L., Ma, L., & Wang, J. (2025) · BMC Genomics · doi:10.1186/s12864-025-12027-5 · Cited by 1

Uncovering pharmacological mechanisms of Phellinus linteus on focal segmental glomeruloscleosis rats through tandem mass tag-based quantitative proteomic analysis, network pharmacology analysis and experimental validation.

Wan, F., Ruchun, Y., & Yuewen, T. (2023) · PubMed Central · doi:10.19852/j.cnki.jtcm.20230524.002 · Cited by 1

The Characteristics of Peripheral Blood Mononuclear Cells in Takayasu Arteritis by Single Cell RNA SequencingPreprint

Gao, Q., Yu, J., Chen, Z., Diao, Y., Miao, Y., Jinfeng, Y., Jia, J., Li, W., & Li, Y. (2021) · doi:10.22541/au.161184064.45445840/v1

Secretion of Cardioprotective Factors from Cardiac Inducing Colonies (CICS) Derived from Germline Pluripotent Stem Cells (HGPSCS) to Combat Myocardial Fibrosis

Mahapatra, S. (2021) · DigitalGeorgetown (Georgetown University Library)

Relationship between circulating thrombospondin‐1 messenger ribonucleic acid and microribonucleic acid ‐194 levels in Chinese patients with type 2 diabetic kidney disease: The outcomes of a case–control study

Ma, N., Liu, W., Xu, N., Yin, D., Zheng, P., Wang, G., Yuan, H., Zhang, J., Han, G., Yang, C., et al. (2024) · Journal of Diabetes Investigation · doi:10.1111/jdi.14252

Modulating the Cell Proteome

Stilwell, J. (2024) · doi:10.32920/26866660

PATHOPHYSIOLOGICAL AND STRUCTURAL PECULIARITIES OF CARDIAC FIBROSIS DEVELOPMENT IN ATRIAL FIBRILLATION

Perepeka, Y. O. (2024) · Актуальні проблеми сучасної медицини Вісник Української медичної стоматологічної академії · doi:10.31718/2077-1096.24.3.251

Angular Gait Behavior and Muscle Collagen Remodeling in Rats of Different Ages and Diets Submitted to Intense Physical TrainingPreprint

Jimenes, D. R., Teixeira, N. R., de Oliveira, S. S. C., Rinaldi, W., Barbosa, C. P., & Deprá, P. P. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5147753

Genetic compensation in podocalyxin-like mutants during zebrafish liver developmentPreprint

Ross, A. N., Miscik, N. M., Kalasekar, S. M., Harris, J. D., Tran, L., Saxena, A., Baker, S. A., & Evason, K. J. (2025) · eLife · doi:10.7554/elife.106460

Genetic compensation in podocalyxin-like mutants during zebrafish liver developmentPreprint

Ross, A. N., Miscik, N. M., Kalasekar, S. M., Harris, J. D., Tran, L., Saxena, A., Baker, S. A., & Evason, K. J. (2025) · eLife · doi:10.7554/elife.106460.1

Three-dimensional gait kinematics and muscle collagen remodeling in rats of different ages and diets subjected to high-intensity exercise

Jimenes, D. R., Teixeira, N. R., de Oliveira, S. S. C., Mathias, P. C. D. F., Almeida, D. L., Rinaldi, W., Barbosa, C. P., & Deprá, P. P. (2025) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2025.112887

Plasma Thrombospondin-1 in Etiology-Specific Associations with Proteinuria Events in Pediatric Chronic Kidney Disease

Lu, P., Liao, W.-T., Hsu, C., Tain, Y., & Chou, C. (2025) · Children · doi:10.3390/children12081101

THBS1 as a candidate biomarker and fibrotic mediator in radiation-induced liver injury: insights from TMT-labeled quantitative proteomics

Wang, Z., Wu, T., Wang, H., Deng, Y., Liu, J., Wang, T., Ren, X., Sun, Y., Zhang, H., Yang, D., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1659870

Additional file 1 of Effects of Doxorubicin on Extracellular Matrix Regulation in Primary Cardiac Fibroblasts from Mice

Skaggs, C., Nick, S. J., Patricelli, C., Bond, L., Woods, K., Woodbury, L. G., Oxford, J. T., & Pu, X. (2024) · Figshare · doi:10.6084/m9.figshare.26641285

Thrombospondin‐1 Is a Contact Sensor Triggering Adhesion in T Cells and Platelets While Differentially Regulating 2D and 3D Motility in T Cells

Sundqvist, K. (2025) · European Journal of Immunology · doi:10.1002/eji.70122

CGRP/TSP1 Signaling Dampens Corneal Inflammation and Fibrosis by Targeting A2M During Corneal Stromal Wound Healing

Ge, H., Zhang, Y., Guo, Q., Li, Y., Yang, L., Zang, X., Xie, J., Wang, Y., Li, Y., Qi, X., et al. (2026) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.67.1.10

Immune Checkpoint Inhibitor-Induced Cardiovascular Disease: The Role of Accelerated Senescence in Vascular Dysfunction

Casso-Chapa, B., Paniagua-Bojorges, A., Palaskas, N. L., Nead, K. T., Samanthapudi, V. S. K., Lee, J., Mejia, G. F., Hoang, O. N., Kim, J. H., Lin, S. H., et al. (2026) · Antioxidants and Redox Signaling · doi:10.1177/15230864251410546

Transcriptomic profiling of chlorogenic acid and taurine treatment in human skin cells provides insights into cellular senescence mechanisms

Kim, B., Shin, J., Hong, I.-S., Ahn, Y., Seo, J. Y., Shin, J. Y., Lee, S., Jun, S., Jeong, E. T., Jo, H., et al. (2026) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2026.1748185

Rôle de la thrombospondine-1 dans le développement des maladies rénales

Bigé, N., Boffa, J., Lepeytre, F., & Shweke, N. (2013) · médecine/sciences · doi:10.1051/medsci/20132912017 · Cited by 9

The thrombospondin 1-TGF- axis in fibrotic renal disease

Hugo, C. (2003) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfg159 · Cited by 55

Editorial Comments The thrombospondin 1–TGF-b axis in fibrotic renal disease

Hugo, C. (2014)

Action of thrombospondin-1 and it's relationship with Renal fibrosis

陈芷珉, & 郑法雷 (2008) · 国际泌尿系统杂志 · doi:10.3760/cma.j.issn.1673-4416.2008.01.027

Thrombospondin-1 is a major activator of TGF-β in fibrotic renal disease in the rat in vivo

Daniel, C., Wiede, J., Krutzsch, H. C., Ribeiro, S. M. F., Roberts, D. D., Murphy-Ullrich, J. E., & Hugo, C. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00395.x · Cited by 142