The DOI matches its Crossref record; 182 of the 182 references it cites were found in a registry or an index.
Thrombospondin 1 and Its Diverse Roles as a Regulator of Extracellular Matrix in Fibrotic Disease
Open accessAbstract
Thrombospondin 1 (TSP1) is a matricellular extracellular matrix protein that has diverse roles in regulating cellular processes important for the pathogenesis of fibrotic diseases. We will present evidence for the importance of TSP1 control of latent transforming growth factor beta activation in renal fibrosis with an emphasis on diabetic nephropathy. Other functions of TSP1 that affect renal fibrosis, including regulation of inflammation and capillary density, will be addressed. Emerging roles for TSP1 N-terminal domain regulation of collagen matrix assembly, direct effects of TSP1–collagen binding, and intracellular functions of TSP1 in mediating endoplasmic reticulum stress responses in extracellular matrix remodeling and fibrosis, which could potentially affect renal fibrogenesis, will also be discussed. Finally, we will address possible strategies for targeting TSP1 functions to treat fibrotic renal disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“CellChat predicted strong incoming SDC4-mediated signals through THBS1, TNXB, TNC, COL4A, and ANGPTL4 (Figure S5J), all of which are involved in ECM regulation.54,55,56”
From Cellular senescence in human liver under normal aging and cancer (2026) · cites this paper as [55]
In the citing paper
“all of which are involved in ECM regulation.54,55,56”
From Cellular senescence in human liver under normal aging and cancer (2026) · cites this paper as [55]
Citations
Cites
Signal integration in the endoplasmic reticulum unfolded protein response
Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,431
Mechanisms of fibrosis: therapeutic translation for fibrotic disease
Wynn, T. A., & Ramalingam, T. R. (2012) · Nature Medicine · doi:10.1038/nm.2807 · Cited by 3,541
Thrombospondin-1 Is a Major Activator of TGF-β1 In Vivo
Crawford, S. E., Stellmach, V. M., Murphy-Ullrich, J. E., Ribeiro, S. M. F., Lawler, J., Hynes, R. O., Boivin, G. P., & Bouck, N. (1998) · Cell · doi:10.1016/s0092-8674(00)81460-9 · Cited by 1,176
Self-citationEnd-stage renal failure in type 2 diabetes: A medical catastrophe of worldwide dimensions
Ritz, E., Rychlík, I., Locatelli, F., & Halimi, S. (1999) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(99)70035-1 · Cited by 811
Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1.
Bornstein, P. (1995) · The Journal of cell biology · doi:10.1083/jcb.130.3.503 · Cited by 666
Sharma, K., & Ziyadeh, F. N. (1995) · Diabetes · doi:10.2337/diab.44.10.1139 · Cited by 576
Lahn, M. M. F., Herbertz, S., Sawyer, J. S., Stauber, A. J., Gueorguieva, I., Driscoll, K. E., Estrem, S. T., Cleverly, A., Desaiah, D., Guba, S. C., et al. (2015) · Drug Design Development and Therapy · doi:10.2147/dddt.s86621 · Cited by 571
Kyriakides, T. R., Zhu, Y.-H., Smith, L. T., Bain, S. D., Yang, Z., Lin, M. T., Danielson, K. G., Iozzo, R. V., LaMarca, M. E., McKinney, C. E., et al. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.2.419 · Cited by 503
Lee, J., Bhang, D. H., Beede, A. M., Huang, T. L., Stripp, B. R., Bloch, K. D., Wagers, A. J., Tseng, Y., Ryeom, S. W., & Kim, C. F. (2014) · Cell · doi:10.1016/j.cell.2013.12.039 · Cited by 494
The de-adhesive activity of matricellular proteins: is intermediate cell adhesion an adaptive state?
Murphy-Ullrich, J. E. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12609 · Cited by 483
Self-citation
Research works printed but not linked: 1
- Schultz-Cherry S, Murphy-Ullrich JE. Thrombospondin causes activation of latent transforming growth factor-beta secreted by endothelial cells by a novel mechanism. J Cell Biol. 1993;122(4):923–32.
Cited by
Sorted by citations
Items 101–104 of 104
Kim, Y., Ham, B., Kim, Y., Jung, B. H., Park, J., & Lee, H. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.153785
Flavonoids with anti-angiogenic potential in cancer
Kashyap, D., Sharma, R., Munda, V. S., Garg, V. K., Thakur, S., Sharma, D., Okpala, C. O. R., & Dhiman, V. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-42855-5.00007-8
Xiao, L., Long, Y., Hong, X., Liu, X., Hu, Y., Xu, X., & Liu, Y. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.08.041
Yang, S., Hou, C., Wang, H., Liu, L., Li, J., 闫乃红, Tian, X., & Chen, G. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1958871
Metadata
- Authors
- Murphy-Ullrich, J. E.
- Affiliations
- University of Alabama at Birmingham (US)
- Corresponding author
- Murphy-Ullrich, Joanne E.
- Venue
- Journal of Histochemistry & Cytochemistry
- Publisher
- SAGE Publications
- Published
- 2019-05-22
- Volume
- 67
- Issue
- 9
- Pages
- 683-699
- ISSN
- 0022-1554 (ISSN-L)
- 1551-5044
- PMC
- PMC6713974
- OpenAlex
- W2946132178
- Cited by
- 104
- References
- 182
- Citations by year
- 2026: 10 · 2025: 23 · 2024: 16 · 2023: 14 · 2022: 18 · 2021: 16 · 2020: 6
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Histochemistry & Cytochemistry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- national institutes of health (NIH grants 1R01 CA175012 and 1R01 EY027924)
- university of alabama at birmingham (Alabama Drug Discovery Alliance)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
- Keywords
- thrombospondin-1, extracellular matrix, renal fibrosis, diabetic nephropathy, latent TGF-beta activation, matricellular proteins, inflammation, capillary density, endoplasmic reticulum stress, extracellular matrix remodeling
- MeSH terms
- Animals, Collagen, Diabetic Nephropathies, Extracellular Matrix, Fibrosis, Humans, Kidney, Transforming Growth Factor beta, Thrombospondin 1, Renal Insufficiency, Chronic
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
