Comparative Genomics
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Primers provide a concise introduction into an important aspect of biology
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The problem of species not being independent can be exacerbated by additional levels of non-independence, including genes within genomes and genomes of the same or closely related species.
“In genomic datasets, data points can correspond to genomes or even individual genes, meaning the problem of species not being independent can be exacerbated by additional levels of non-independence, including genes within genomes, such as those carried on the same replicon, and genomes of the same or closely related species16,19,21–26.”
From A phylogenetic approach to comparative genomics (2025) · cites this paper as [21]
The Abstract discusses comparisons between genomes at different phylogenetic distances, and the Prospects section defines relationships among homologous genes. Neither passage addresses statistical non-independence among species, genes within a genome, or genomes of closely related species. Searches for non-independence and independent phylogenetic comparisons found no passage making that point; page numbers were not available in our copy. (LLM, conf=0.72)
Experimental — accuracy not yet measuredThe problem of non-independence can be exacerbated when examining genomes or genes.
“This problem of non-independence can be exacerbated when examining genomes or genes.”
From A phylogenetic approach to comparative genomics (2025) · cites this paper as [21]
The Abstract discusses comparing genomes at different phylogenetic distances, and Prospects notes that related species retain features from a common ancestor. Neither passage addresses whether a problem of non-independence is exacerbated when examining genomes or genes; searches for non-independence and independent observations found no passage making that point. No page numbers are available in our copy. (LLM, conf=0.70)
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Cites
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Cited by
Sorted by citations
Adaptive laboratory evolution—Principles and applications for biotechnology
Dragosits, M., & Mattanovich, D. (2013) · Microbial Cell Factories · doi:10.1186/1475-2859-12-64 · Cited by 827 · see citing works
A phylogenetic approach to comparative genomics
Dewar, A. E., Belcher, L. J., & West, S. A. (2025) · Nature Reviews Genetics · doi:10.1038/s41576-024-00803-0 · Cited by 41 · see citing works
- Authors
- Hardison, R. C.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Hardison, Ross C
- ORCID
- Hardison, Ross C
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2003-11-17
- Volume
- 1
- Issue
- 2
- Pages
- e58
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- PMC
- PMC261895
- OpenAlex
- W4229799243
- Cited by
- 252
- References
- 2
- Citations by year
- 2026: 9 · 2025: 7 · 2024: 5 · 2023: 8 · 2022: 18 · 2021: 16 · 2020: 11 · 2019: 12 · 2018: 5 · 2017: 11 · 2016: 15 · 2015: 7 · 2014: 6 · 2013: 3 · 2012: 10
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, other-oa)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genetics, Bioinformatics, and Biomedical Research
- Keywords
- comparative genomics, evolutionary biology
- MeSH terms
- Animals, Humans, Phylogeny, Genome, Sequence Analysis, DNA, Evolution, Molecular, Computational Biology, Internet, Genomics, Databases, Genetic
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