The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
No Evidence of Neandertal mtDNA Contribution to Early Modern Humans
Open accessAbstract
The retrieval of mitochondrial DNA (mtDNA) sequences from four Neandertal fossils from Germany, Russia, and Croatia has demonstrated that these individuals carried closely related mtDNAs that are not found among current humans. However, these results do not definitively resolve the question of a possible Neandertal contribution to the gene pool of modern humans since such a contribution might have been erased by genetic drift or by the continuous influx of modern human DNA into the Neandertal gene pool. A further concern is that if some Neandertals carried mtDNA sequences similar to contemporaneous humans, such sequences may be erroneously regarded as modern contaminations when retrieved from fossils. Here we address these issues by the analysis of 24 Neandertal and 40 early modern human remains. The biomolecular preservation of four Neandertals and of five early modern humans was good enough to suggest the preservation of DNA. All four Neandertals yielded mtDNA sequences similar to those previously determined from Neandertal individuals, whereas none of the five early modern humans contained such mtDNA sequences. In combination with current mtDNA data, this excludes any large genetic contribution by Neandertals to early modern humans, but does not rule out the possibility of a smaller contribution.
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Citations
Cites
Mitochondrial DNA and human evolution
Cann, R. L., Stoneking, M., & Wilson, A. C. (1987) · Nature · doi:10.1038/325031a0 · Cited by 3,100
Hofreiter, M., Serre, D., Poinar, H. N., Kuch, M., & Pääbo, S. (2001) · Nature Reviews Genetics · doi:10.1038/35072071 · Cited by 781
Self-citationHofreiter, M. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.23.4793 · Cited by 684
Self-citationModern human origins: progress and prospects
Stringer, C. (2002) · Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences · doi:10.1098/rstb.2001.1057 · Cited by 534 · cited 2×
“…Wolpoff et al. 1984, 2000; Duarte et al. 1999; Hawks and Wolpoff 2001), proponents of a ‘‘single African origin’’ of contemporary humans claim that negligible genetic interaction took place (Cann et al. 1987; Stringer and Andrews 1988; Ingman et al. 2000; Underhill et al. 2000; Stringer 2002).”
BackgroundDetecting Ancient Admixture in Humans Using Sequence Polymorphism Data
Wall, J. D. (2000) · Genetics · doi:10.1093/genetics/154.3.1271 · Cited by 116
Cited by
A draft sequence of the Neandertal genome
Green, R. E., Krause, J., Briggs, A. W., Maricic, T., Stenzel, U., Kircher, M., Patterson, N., Li, H., Zhai, W., Fritz, M. H.-Y., et al. (2010) · Science · doi:10.1126/science.1188021 · Cited by 4,318
Self-citationGenetic history of an archaic hominin group from Denisova Cave in Siberia
Reich, D., Green, R. E., Kircher, M., Krause, J., Patterson, N., Durand, E. Y., Viola, B., Briggs, A. W., Stenzel, U., Johnson, P. L. F., et al. (2010) · Nature · doi:10.1038/nature09710 · Cited by 1,991
Self-citationAncient DNA and the rewriting of human history: be sparing with Occam’s razor
Haber, M., Mezzavilla, M., Xue, Y., & Tyler-Smith, C. (2016) · Genome Biology · doi:10.1186/s13059-015-0866-z · Cited by 1,924
Testing for ancient admixture between closely related populations
Durand, E. Y., Patterson, N., Reich, D., & Slatkin, M. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr048 · Cited by 1,375
Genetic analyses from ancient DNA
Pääbo, S., Poinar, H., Serre, D., Jaenicke-Després, V., Hebler, J., Rohland, N., Kuch, M., Krause, J., Vigilant, L., & Hofreiter, M. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.37.110801.143214 · Cited by 1,333
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Metadata
- Authors
- Serre, D., Langaney, A., Chech, M., Teschler-Nicola, M., Paunovic, M., Mennecier, P., Hofreiter, M., Possnert, G., & Pääbo, S.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2004-03-16
- Volume
- 2
- Issue
- 3
- Pages
- e57
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2038614704
- Cited by
- 436
- References
- 5
- FWCI
- 283.65
- Type
- journal article
- Language
- en
- Open access
- gold
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