Detecting Ancient Admixture in Humans Using Sequence Polymorphism Data
Abstract
A debate of long-standing interest in human evolution centers around whether archaic human populations (such as the Neanderthals) have contributed to the modern gene pool. A model of ancient population structure with recent mixing is introduced, and it is determined how much information (i.e., sequence data from how many unlinked nuclear loci) would be necessary to distinguish between different demographic scenarios. It is found that ~50–100 loci are necessary if plausible parameter estimates are used. There are not enough data available at the present to support either the “single origin” or the “multiregional” model of modern human evolution. However, this information should be available in a few years.
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Unusually large variation in LD within the human genome suggests that ancient human populations were subdivided.
“Unusually large variation in LD within the human genome already suggests that ancient human populations were subdivided111,112”
From Linkage disequilibrium--understanding the evolutionary past and mapping the medical future. (2008) · cites this paper as [111]
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- Authors
- Wall, J. D.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Wall, Jeffrey D
- ORCID
- Wall, Jeffrey D
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-03-01
- Volume
- 154
- Issue
- 3
- Pages
- 1271-1279
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W2107737723
- Cited by
- 116
- References
- 62
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 7 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 3 · 2013: 5 · 2012: 4
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Keywords
- Neanderthal admixture, human evolution, population structure, demographic models, sequence variation, sample size requirements, multiregional model
- MeSH terms
- Humans, Models, Genetic, Polymorphism, Genetic, Models, Statistical
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