The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Gene Recruitment of the Activated INO1 Locus to the Nuclear Membrane
Open accessAbstract
The spatial arrangement of chromatin within the nucleus can affect reactions that occur on the DNA and is likely to be regulated. Here we show that activation of INO1 occurs at the nuclear membrane and requires the integral membrane protein Scs2. Scs2 antagonizes the action of the transcriptional repressor Opi1 under conditions that induce the unfolded protein response (UPR) and, in turn, activate INO1. Whereas repressed INO1 localizes throughout the nucleoplasm, the gene is recruited to the nuclear periphery upon transcriptional activation. Recruitment requires the transcriptional activator Hac1, which is produced upon induction of the UPR, and is constitutive in a strain lacking Opi1. Artificial recruitment of INO1 to the nuclear membrane permits activation in the absence of Scs2, indicating that the intranuclear localization of a gene can profoundly influence its mechanism of activation. Gene recruitment to the nuclear periphery, therefore, is a dynamic process and appears to play an important regulatory role.
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Cites
Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Regulation of Chromatin Remodeling by Inositol Polyphosphates
Steger, D. J., Haswell, E. S., Miller, A. L., Wente, S. R., & O'Shea, E. K. (2003) · Science · doi:10.1126/science.1078062 · Cited by 352
Modulation of ATP-Dependent Chromatin-Remodeling Complexes by Inositol Polyphosphates
Shen, X., Xiao, H., Ranallo, R., Wu, W.-H., & Wu, C. (2003) · Science · doi:10.1126/science.1078068 · Cited by 338
Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding
Cobb, B. S., Morales-Alcelay, S., Kleiger, G., Brown, K. E., Fisher, A. G., & Smale, S. T. (2000) · Genes & Development · doi:10.1101/gad.816400 · Cited by 252
Cited by
Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions
Lanctôt, C., Cheutin, T., Cremer, M., Cavalli, G., & Cremer, T. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2041 · Cited by 781
Schuck, S., Prinz, W. A., Thorn, K. S., Voss, C., & Walter, P. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200907074 · Cited by 580
Self-citationThe nuclear envelope and transcriptional control
Akhtar, A., & Gasser, S. M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2122 · Cited by 441
Structural Basis of FFAT Motif-Mediated ER Targeting
Kaiser, S. E., Brickner, J. H., Reilein, A. R., Fenn, T. D., Walter, P., & Brunger, A. T. (2005) · Structure · doi:10.1016/j.str.2005.04.010 · Cited by 266
Self-citationLong-Range Chromatin Interactions
Dekker, J., & Misteli, T. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019356 · Cited by 255
Metadata
- Authors
- Brickner, J. H., & Walter, P.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2004-09-28
- Volume
- 2
- Issue
- 11
- Pages
- e342
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2052586663
- Cited by
- 398
- References
- 4
- FWCI
- 7.87
- Type
- journal article
- Language
- en
- Open access
- gold
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