The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Replication of Norovirus in Cell Culture Reveals a Tropism for Dendritic Cells and Macrophages
Open accessAbstract
Noroviruses are understudied because these important enteric pathogens have not been cultured to date. We found that the norovirus murine norovirus 1 (MNV-1) infects macrophage-like cells in vivo and replicates in cultured primary dendritic cells and macrophages. MNV-1 growth was inhibited by the interferon-alphabeta receptor and STAT-1, and was associated with extensive rearrangements of intracellular membranes. An amino acid substitution in the capsid protein of serially passaged MNV-1 was associated with virulence attenuation in vivo. This is the first report of replication of a norovirus in cell culture. The capacity of MNV-1 to replicate in a STAT-1-regulated fashion and the unexpected tropism of a norovirus for cells of the hematopoietic lineage provide important insights into norovirus biology.
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Metadata
- Authors
- Wobus, C. E., Karst, S. M., Thackray, L. B., Chang, K.-O., Sosnovtsev, S. V., Belliot, G., Krug, A., Mackenzie, J. M., Green, K. Y., & Virgin, H. W.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2004-11-30
- Volume
- 2
- Issue
- 12
- Pages
- e432
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2132969117
- Cited by
- 833
- References
- 29
- FWCI
- 13.77
- Type
- journal article
- Language
- en
- Open access
- gold
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