The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Functional Evolution of a cis-Regulatory Module
Open accessAbstract
Lack of knowledge about how regulatory regions evolve in relation to their structure-function may limit the utility of comparative sequence analysis in deciphering cis-regulatory sequences. To address this we applied reverse genetics to carry out a functional genetic complementation analysis of a eukaryotic cis-regulatory module-the even-skipped stripe 2 enhancer-from four Drosophila species. The evolution of this enhancer is non-clock-like, with important functional differences between closely related species and functional convergence between distantly related species. Functional divergence is attributable to differences in activation levels rather than spatiotemporal control of gene expression. Our findings have implications for understanding enhancer structure-function, mechanisms of speciation and computational identification of regulatory modules.
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Cites
Evolutionary changes in cis and trans gene regulation
Wittkopp, P. J., Haerum, B. K., & Clark, A. G. (2004) · Nature · doi:10.1038/nature02698 · Cited by 873
Dobzhansky, T. (1936) · Genetics · doi:10.1093/genetics/21.2.113 · Cited by 732
Wu, C.-I., & Ting, C.-T. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1269 · Cited by 532
Phylogenetic Shadowing of Primate Sequences to Find Functional Regions of the Human Genome
Boffelli, D., McAuliffe, J., Ovcharenko, D., Lewis, K. D., Ovcharenko, I., Pachter, L., & Rubin, E. M. (2003) · Science · doi:10.1126/science.1081331 · Cited by 516
Goto, T., Macdonald, P., & Maniatis, T. (1989) · Cell · doi:10.1016/0092-8674(89)90916-1 · Cited by 277
The eve stripe 2 enhancer employs multiple modes of transcriptional synergy
Arnosti, D. N., Barolo, S., Levine, M., & Small, S. (1996) · Development · doi:10.1242/dev.122.1.205 · Cited by 226
Cited by
The ENCODE Project Consortium (2007) · Nature · doi:10.1038/nature05874 · Cited by 5,223
The evolution of gene regulation by transcription factors and microRNAs
Chen, K., & Rajewsky, N. (2007) · Nature Reviews Genetics · doi:10.1038/nrg1990 · Cited by 1,547
Cis-regulatory elements: Molecular mechanisms and evolutionary processes underlying divergence
Wittkopp, P. J., & Kalay, G. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3095 · Cited by 1,231
Enhancer Evolution across 20 Mammalian Species
Villar, D., Berthelot, C., Aldridge, S., Rayner, T. F., Lukk, M., Pignatelli, M., Park, T. J., Deaville, R., Erichsen, J. T., Jasinska, A. J., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.006 · Cited by 825
An Atomic Model of the Interferon-β Enhanceosome
Panne, D., Maniatis, T., & Harrison, S. C. (2007) · Cell · doi:10.1016/j.cell.2007.05.019 · Cited by 625
Metadata
- Authors
- Ludwig, M. Z., Palsson, A., Alekseeva, E., Bergman, C. M., Nathan, J., & Kreitman, M.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2005-03-15
- Volume
- 3
- Issue
- 4
- Pages
- e93
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2025665146
- Cited by
- 210
- References
- 6
- FWCI
- 9.10
- Type
- journal article
- Language
- en
- Open access
- gold
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