The cell nucleus and aging: tantalizing clues and hopeful promises

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

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Lamin A Truncation in Hutchinson-Gilford Progeria

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Genetic pathways that regulate ageing in model organisms

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Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome

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The nuclear lamina comes of age

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Genomic instability in laminopathy-based premature aging

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Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

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Cancer and ageing: rival demons?

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Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation

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LMNA mutations in atypical Werner's syndrome

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The Hutchinson-Gilford progeria syndrome

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Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

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Abnormal nuclear shape and impaired mechanotransduction in emerin-deficient cells

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Lamin A and ZMPSTE24 (FACE-1) defects cause nuclear disorganization and identify restrictive dermopathy as a lethal neonatal laminopathy

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Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae

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Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson–Gilford progeria syndrome mutation

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Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

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Incomplete processing of mutant lamin A in Hutchinson–Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition

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Concepts in nuclear architecture

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The role of isoprenylation in membrane attachment of nuclear lamins: A single point mutation prevents proteolytic cleavage of the lamin A precursor and confers membrane binding properties

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Genetic Modulation of Senescent Phenotypes in Homo sapiens

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Genome instability in progeria: when repair gets old

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Alternative Splicing at the Intersection of Biological Timing, Development, and Stress Responses

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Human laminopathies: nuclei gone genetically awry

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Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson–Gilford progeria syndrome

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Epigenetic alterations in aging

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The epigenetic magic of histone lysine methylation

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Nuclear morphologies: their diversity and functional relevance

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Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse

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Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A

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Human ZMPSTE24 disease mutations: residual proteolytic activity correlates with disease severity

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New Approaches to Progeria

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Hematopoietic Stem Cell Aging: Wrinkles In Stem Cell Potential

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Analysis of Prelamin A Biogenesis Reveals the Nucleus to be a CaaX Processing Compartment

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Epigenomic drivers of immune dysfunction in aging

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Hutchinson–Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substrates

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Gene PositioningPreprint

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SCFSlimb ubiquitin ligase suppresses condensin II–mediated nuclear reorganization by degrading Cap-H2

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DNA-damage accumulation and replicative arrest in Hutchinson–Gilford progeria syndrome

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Transformation Resistance in a Premature Aging Disorder Identifies a Tumor-Protective Function of BRD4

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High prevalence of laminopathies among patients with metabolic syndrome

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Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease.

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ZMPSTE24, an integral membrane zinc metalloprotease with a connection to progeroid disorders

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Eukaryotic gene regulation in three dimensions and its impact on genome evolution

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Requirements for Efficient Proteolytic Cleavage of Prelamin A by ZMPSTE24

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The induction of a nucleoplasmic reticulum by prelamin A accumulation requires CTP:phosphocholine cytidylyltransferase-α

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The weakness of senescent dermal fibroblasts

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Nuclear Stiffening Inhibits Migration of Invasive Melanoma Cells

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New Insights into Mechanisms and Functions of Nuclear Size Regulation

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LBR mutation and nuclear envelope defects in a patient affected with Reynolds syndrome

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Restoring SIRT6 Expression in Hutchinson-Gilford Progeria Syndrome Cells Impedes Premature Senescence and Formation of Dysmorphic Nuclei

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At a glance: Cellular biology for engineers

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Mechanical Role of Nesprin-1-Mediated Nucleus–Actin Filament Binding in Cyclic Stretch-Induced Fibroblast Elongation

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CAAX Processing and Yeast a-Factor Biogenesis

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Endothelial Nuclear Lamina in Mechanotransduction Under Shear Stress

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Skin and Sural Nerve Biopsies: Ultrastructural Findings in the First Genetically Confirmed Cases of CADASIL in Serbia

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Das Rätsel der Alterung: Viele Theorien, viele offene Fragen

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The Premature Aging Syndrome Hutchinson-Gilford Progeria: Insights Into Normal Aging

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Therapeutic Use of Cloning: Osmangazi Turk Identical Embryonic Stem Cells and Embryonic Stem Cell Transfer to Diabetic Mice

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Senescence in Aging, Within the Brain and Other Diseases: Mechanisms and Interventions

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Cellular Organization of the Gastrointestinal Tract

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Transcriptional Functions of DNA Repair Proteins Involved in Premature Aging

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Envoltura nuclear, laminopatías y envejecimiento acelerado

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Lizozom

Güven, M. (2025) · doi:10.5152/7146

Endositoz

Tunçdemi̇r, M. (2025) · doi:10.5152/7133

Hücre Membranının Yapısı ve Hücre Membranlarından Moleküler Taşınım

Tunçdemi̇r, M. (2025) · doi:10.5152/7132

Tıbbi Biyoloji

Tunçdemi̇r, M., Cerrahpaşa Tıp Fakültesi, T. T. B. B., Cerrahpaşa Tıp Fakültesi, T. T. B. B., Çırakoğlu, A., Güven, M., Cengiz, M., Baykara, O., İstanbul Üniversite-Cerrahpaşa, C. T. F., & Argüden, Y. T. (2025) · doi:10.5152/7100

Proteazom

Dağıstanlı, F. K. (2025) · doi:10.5152/7147

Distal Gene Expression Governed by Lamins and Nesprins via Chromatin Conformation ChangePreprint

Zhang, H., Lei, Z., Momen‐Heravi, F., & Qin, P. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.01.646570

Distal Gene Expression Governed by Lamins and Nesprins via Chromatin Conformation ChangePreprint

Zhang, H., Lei, Z., Momen‐Heravi, F., & Qin, P. (2025) · eLife · doi:10.7554/elife.106924.1

Distal Gene Expression Governed by Lamins and Nesprins via Chromatin Conformation ChangePreprint

Zhang, H., Lei, Z., Momen‐Heravi, F., & Qin, P. (2025) · eLife · doi:10.7554/elife.106924

Distal Gene Expression Governed by Lamins and Nesprins via Chromatin Conformation ChangePreprint

Zhang, H., Lei, Z., Momen‐Heravi, F., & Qin, P. (2025) · eLife · doi:10.7554/elife.106924.2

Mechanisms of Aging in Bone Marrow Stem Cells

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Tantalizing Glimpses into a Fragmented Genome

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The Cell Nucleus and Aging: Tantalizing Clues and Hopeful Promises-0

Paola Scaffidi, L. G. (2011) · Figshare · doi:10.6084/m9.figshare.23325

Lives of a Cell: 40 Years Later, A Third Interpretation

Dato, V. (2015) · Emerging infectious diseases · doi:10.3201/eid2104.110793

Keep on Laying Eggs Mama, RNAi My Reproductive Aging Blues Away

Kumar, S., Kocsisova, Z., & Kornfeld, K. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004808 · Cited by 3 · see citing works