Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation

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The Hallmarks of Aging

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Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

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The senescence-associated secretory phenotype and its regulation

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The Aging Epigenome

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Delayed ageing through damage protection by the Arf/p53 pathway

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Splicing-directed therapy in a new mouse model of human accelerated aging

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Senescence-associated inflammatory responses: aging and cancer perspectives

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Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

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Progeria syndromes and ageing: what is the connection?

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Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

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Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations

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Werner and Hutchinson–Gilford progeria syndromes: mechanistic basis of human progeroid diseases

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Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response

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Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice

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Human lipodystrophies linked to mutations in A-type lamins and to HIV protease inhibitor therapy are both associated with prelamin A accumulation, oxidative stress and premature cellular senescence

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DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A

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Vascular senescence in cardiovascular and metabolic diseases

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Molecular bases of progeroid syndromes

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Methionine Restriction Extends Lifespan in Progeroid Mice and Alters Lipid and Bile Acid Metabolism

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Cancer and ageing: convergent and divergent mechanisms

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FOXP1 controls mesenchymal stem cell commitment and senescence during skeletal aging

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Ionizing radiation-induced long-term expression of senescence markers in mice is independent of p53 and immune status

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Hallmarks of progeroid syndromes: lessons from mice and reprogrammed cells

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Mechanisms of cardiovascular disease in accelerated aging syndromes

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p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice

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Mouse Models to Disentangle the Hallmarks of Human Aging

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Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A

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Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid

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HGPS and related premature aging disorders: From genomic identification to the first therapeutic approaches

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A p53-Dependent Response Limits Epidermal Stem Cell Functionality and Organismal Size in Mice with Short Telomeres

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Premature Senescence of Vascular Cells Is Induced by HIV Protease Inhibitors: Implication of Prelamin A and Reversion by Statin

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Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A‐type lamins as intrinsic modulators of ageing in adult stem cells and their niches

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Contribution of proteases to the hallmarks of aging and to age-related neurodegeneration

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Genomic instability and DNA replication defects in progeroid syndromes

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The yin and yang of the Cdkn2a locus in senescence and aging

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Mutant mice with small amounts of BubR1 display accelerated age-related gliosis

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Lamin B1 sequesters 53BP1 to control its recruitment to DNA damage

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The cell nucleus and aging: tantalizing clues and hopeful promises

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Reduced endosomal microautophagy activity in aging associates with enhanced exocyst‐mediated protein secretion

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Longevity and rejuvenation effects of cell reprogramming are decoupled from loss of somatic identity.

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Making Young Tumors Old: A New Weapon Against Cancer?

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