The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells
Open accessAbstract
Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are present in both Mtb-infected and uninfected humans. We show by limiting dilution analysis that nonclassically restricted CD8+ T cells are universally present, but predominate in Mtb-uninfected individuals. Interestingly, these Mtb-reactive cells expressed the Valpha7.2 T-cell receptor (TCR), were restricted by the nonclassical MHC (HLA-Ib) molecule MR1, and were activated in a transporter associated with antigen processing and presentation (TAP) independent manner. These properties are all characteristics of mucosal associated invariant T cells (MAIT), an "innate" T-cell population of previously unknown function. These MAIT cells also detect cells infected with other bacteria. Direct ex vivo analysis demonstrates that Mtb-reactive MAIT cells are decreased in peripheral blood mononuclear cells (PBMCs) from individuals with active tuberculosis, are enriched in human lung, and respond to Mtb-infected MR1-expressing lung epithelial cells. Overall, these findings suggest a generalized role for MAIT cells in the detection of bacterially infected cells, and potentially in the control of bacterial infection.
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Citations
Cites
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
Treiner, E., Duban, L., Bahram, S., Radosavljevic, M., Wanner, V., Tilloy, F., Affaticati, P., Gilfillan, S., & Lantz, O. (2003) · Nature · doi:10.1038/nature01433 · Cited by 1,139
Self-citationMICA Engagement by Human Vγ2Vδ2 T Cells Enhances Their Antigen-Dependent Effector Function
Das, H., Groh, V., Kuijl, C., Sugita, M., Morita, C. T., Spies, T., & Bukowski, J. F. (2001) · Immunity · doi:10.1016/s1074-7613(01)00168-6 · Cited by 409
Cited by
MR1 presents microbial vitamin B metabolites to MAIT cells
Kjer-Nielsen, L., Patel, O., Corbett, A. J., Le Nours, J., Meehan, B., Liu, L., Bhati, M., Chen, Z., Kostenko, L., Reantragoon, R., et al. (2012) · Nature · doi:10.1038/nature11605 · Cited by 1,351
Immunology in the liver — from homeostasis to disease
Heymann, F., & Tacke, F. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.200 · Cited by 1,180
Ussher, J. E., Bilton, M., Attwod, E., Shadwell, J., Richardson, R., de Lara, C., Mettke, E., Kurioka, A., Hansen, T. H., Klenerman, P., et al. (2014) · European Journal of Immunology · doi:10.1002/eji.201343509 · Cited by 543
Self-citationA three-stage intrathymic development pathway for the mucosal-associated invariant T cell lineage
Koay, H.-F., Gherardin, N. A., Enders, A., Loh, L., Mackay, L. K., Almeida, C. F., Russ, B. E., Nold-Petry, C. A., Nold, M. F., Bedoui, S., et al. (2016) · Nature Immunology · doi:10.1038/ni.3565 · Cited by 377
Early and nonreversible decrease of CD161++/MAIT cells in HIV infection
Cosgrove, C., Ussher, J. E., Rauch, A., Gärtner, K., Kurioka, A., Hühn, M. H., Adelmann, K., Kang, Y.-H., Fergusson, J. R., Simmonds, P., et al. (2013) · Blood · doi:10.1182/blood-2012-06-436436 · Cited by 316
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Metadata
- Authors
- Gold, M. C., Cerri, S., Smyk-Pearson, S., Cansler, M. E., Vogt, T. M., Delepine, J., Winata, E., Swarbrick, G. M., Chua, W.-J., Yu, Y. Y. L., Lantz, O., Cook, M. S., Null, M. D., Jacoby, D. B., Harriff, M. J., Lewinsohn, D. A., Hansen, T. H., & Lewinsohn, D. M.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-06-29
- Volume
- 8
- Issue
- 6
- Pages
- e1000407
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2008617601
- Cited by
- 673
- References
- 2
- FWCI
- 14.99
- Type
- journal article
- Language
- en
- Open access
- gold
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- Gold, M. C., Cerri, S., Smyk-Pearson, S., Cansler, M. E., Vogt, T. M., Delepine, J., Winata, E., Swarbrick, G. M., Chua, W.-J., Yu, Y. Y. L., Lantz, O., Cook, M. S., Null, M. D., Jacoby, D. B., Harriff, M. J., Lewinsohn, D. A., Hansen, T. H., & Lewinsohn, D. M. (2010). Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells. PLoS Biology. https://doi.org/10.1371/journal.pbio.1000407
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
