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Human Mucosal Associated Invariant T Cells Detect Bacterially Infected Cells
Open accessAbstract
Control of infection with Mycobacterium tuberculosis (Mtb) requires Th1-type immunity, of which CD8+ T cells play a unique role. High frequency Mtb-reactive CD8+ T cells are present in both Mtb-infected and uninfected humans. We show by limiting dilution analysis that nonclassically restricted CD8+ T cells are universally present, but predominate in Mtb-uninfected individuals. Interestingly, these Mtb-reactive cells expressed the Valpha7.2 T-cell receptor (TCR), were restricted by the nonclassical MHC (HLA-Ib) molecule MR1, and were activated in a transporter associated with antigen processing and presentation (TAP) independent manner. These properties are all characteristics of mucosal associated invariant T cells (MAIT), an "innate" T-cell population of previously unknown function. These MAIT cells also detect cells infected with other bacteria. Direct ex vivo analysis demonstrates that Mtb-reactive MAIT cells are decreased in peripheral blood mononuclear cells (PBMCs) from individuals with active tuberculosis, are enriched in human lung, and respond to Mtb-infected MR1-expressing lung epithelial cells. Overall, these findings suggest a generalized role for MAIT cells in the detection of bacterially infected cells, and potentially in the control of bacterial infection.
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Metadata
- Authors
- Gold, M. C., Cerri, S., Smyk-Pearson, S., Cansler, M. E., Vogt, T. M., Delepine, J., Winata, E., Swarbrick, G. M., Chua, W.-J., Yu, Y. Y. L., Lantz, O., Cook, M. S., Null, M. D., Jacoby, D. B., Harriff, M. J., Lewinsohn, D. A., Hansen, T. H., & Lewinsohn, D. M.
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-06-29
- Volume
- 8
- Issue
- 6
- Pages
- e1000407
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- OpenAlex
- W2008617601
- Cited by
- 673
- References
- 50
- FWCI
- 14.99
- Type
- journal article
- Language
- en
- Open access
- gold
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