Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

Percie du Sert, Nathalie, Ahluwalia, Amrita, Alam, Sabina, Avey, Marc T., Baker, Monya, Browne, William J., Clark, Alejandra, Cuthill, Innes C., Dirnagl, Ulrich, Emerson, Michael, Garner, Paul, Holgate, Stephen T., Howells, David W., Hurst, Viki, Karp, Natasha A., Lazic, Stanley E., Lidster, Katie, MacCallum, Catriona J., Macleod, Malcolm, Pearl, Esther J., Petersen, Ole H., Rawle, Frances, Reynolds, Penny, Rooney, Kieron, Sena, Emily S., Silberberg, Shai D., Steckler, Thomas, Würbel, Hanno·2020·PLOS Biology

DOI 10.1371/journal.pbio.3000411

Cited by (2,747)

Items 2,301–2,400 of 2,747

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Glucogenic Precursor Release from Dietary Supply Is a Potential Amplifier of Monosodium-Glutamate Ovary Stimuli in Sheep with Low Involving Key Gene Mediators of the Glutamate Pathway
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Global changes in gene expression and splicing in alcoholic liver disease
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Antinociceptive, anti-inflammatory, and anti-dysmenorrheal activities of aerial parts of Cannabis sativa L. from the sub-middle region of the Vale do São Francisco
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Short- and Long-Term Effects of Undernutrition During Adolescence on Oxidative Status and Glucose Homeostasis in Male and Female Rats
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Influence of Different Warming Methods in Rabbits Subjected to Prolonged Pneumoperitoneum
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First steps in the development of an ovine proximal phalanx fracture and bone defect model: a study of animal welfare and bone healing
Nanett Kvist Nikolaisen, Thomas Colding-Rasmussen, Peter Frederik Horstmann · 2025 · Frontiers in Veterinary Science
Comparison of the effects of spark plasma at two different voltages on aspects influencing skin rejuvenation
Erfan Ghasemi, Mohammad Ali Nilforoushzadeh, Mohammad Reza Khani, Mohammad Amir Amirkhani, Maryam Nouri, Parisa Charipoor, Babak Shokri · 2025 · PLoS ONE
A Deep Learning Pipeline for Mapping in situ Network-level Neurovascular Coupling in Multi-photon Fluorescence Microscopy
Matthew W Rozak, James R. Mester, Ahmadreza Attarpour, Adrienne E. Dorr, Shruti B Patel, Margaret M. Koletar, Mary Elizabeth Hill, JoAnne McLaurin, Maged Goubran, Bojana Stefanovic · 2025 · eLife
Effects of European authorised level of zinc from different sources on the physiology and intestinal ecosystem and performance of piglets weaned at different ages
Clara Negrini, Diana Luise, Federico Correa, Maurizio Mazzoni, Andrea Serra, Alessandra Monteiro, Paolo Trevisi · 2025 · Veterinary and Animal Science
Compensatory placental hypervascularization in a rat model of early-stage, diet-induced maternal obesity
Yhoiss Smiht Muñoz, Sirsa Aleida Hidalgo Ibarra, David Moreno Martínez, Melissa Z. Lopez, Jenniffer Alejandra Castellanos Garzón, Liliana Salazar-Monsalve, María Carolina Pustovrh · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Sequential Galacto- and Xylo-Oligosaccharide Feeding Transiently Modulates Gut Microbiota and Upregulates Intestinal Alkaline Phosphatase in Weaning Piglets
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IL-1 modulation preserves biomolecular, structural and functional integrity of the somatosensory cortex after fetal inflammation
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Impact of Defect Morphology on Alveolar Ridge Preservation: An In Vivo Experimental Study
Qin Tang, Kan Wu, Xiaoyu Liu · 2024 · Annals of Orthodontics and Periodontics Specialty
Systemic microbial antigen administration ameliorates experimental autoimmune encephalomyelitis via MHC-II downregulation in the CNS and secondary lymphoid organs
Marina Kleopatra Boziki, Paschalis Theotokis, Evangelia Kesidou, Eleni Karafoulidou, Ilias Salamotas, Anastasia Chatziefstratiadou, Olga Touloumi, Κωνσταντίνος Σ. Παπαδάκος, Dionyssios N. Sgouras, Ofira Einstein et al. · 2025 · Journal of Neuropathology & Experimental Neurology
Does Defect Configuration Affect the Outcomes of Alveolar Ridge Preservation? An Experimental in Vivo Study
Junji Tagami, Dinh Tran Ngoc Huy, Yi Lin · 2023 · Annals of Orthodontics and Periodontics Specialty
In-situ diet–microbiota associations across taxonomic scales in desert-dwelling amphibians and reptiles
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Successful Treatment of Cutaneous Acanthamoeba polyphaga With Marine Algae, Padina pavonica, Extract: Targeting TLR2/TLR4 Signal and Cytokeratin 18 in Immunocompromised Animals
Sara Salah Abdel-Hakeem, Sherief Mohamed Abdel-Raheem, Hesham Abdel-Moez Ahmed Ismail, Faisal S. Almathen, Sanaa M. F. Gad El-Rab, Awatief F. Hifney · 2025 · Microscopy and Microanalysis
Bioactivity and toxicity of polysaccharides derived from the phytopathogenic mushroom Ganoderma orbiforme cultured in a bioreactor
Danial ‘Aizat Norhisham, John Cheah, Nur Ardiyana Rejab · 2025 · Scientific Reports
Copaiba Oil–Resin Reduces the Alveolar Bone Damage Triggered by Apical Periodontitis in Rats
Rayssa Maitê Farias Nazário, Déborah Ribeiro Frazão, Leonardo Oliveira Bittencourt et al. · 2025 · International Endodontic Journal
Contemporary in vivo rodent electroconvulsive therapy (ECT) models in translational depression research: a systematic review
Evangelos Kokolakis, Michael G. Gottschalk, Sarah Kläffgen, Jan M. Deussing, Angelika Erhardt, Julius C. Pape, Iven-Alex von Mücke-Heim · 2025 · Translational Psychiatry
The Impact of Acute and Chronic Stress and Cannabinoid Extract Injection on Orthodontic Tooth Movement: An Experimental Rat Model Study
Amin Golshah, Mohammad Moslem Imani, Fatemeh Azizi, Farzad Rezaei, Navid Rezaei, Zohre Farhangian, Fatemeh Ghorbani, Nafiseh Nikkerdar · 2025 · International Journal of Dentistry
Research on the current situation of animal models of abdominal wall hernia in the field of animal experiments: a systematic review of 9098 animals with abdominal wall hernia model
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Age-dependent osteoprotective effects of hydroxytyrosol acetate: enhanced bone integrity via gut–bone axis activation
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The ATR inhibitor tuvusertib (M1774) sensitizes prostate carcinoma to natural killer cell-mediated cytotoxicity, which is further augmented by the IL-15 receptor superagonist N-803
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Multimodal objective assessment of a porcine limbal stem cell deficiency model for corneal therapy research
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Additional file 1 of Comparing the gut microbiota of Sichuan golden monkeys across multiple captive and wild settings: roles of anthropogenic activities and host factors
Xuanzhen Liu, Yu, Jianqiu, Huan, Zongjin, Xu, Mei, Song, Ting, Yang, Ruilin, Zhu, Wei, Jiang, Jianping · 2024 · Figshare
Additional file 3 of Improving the consistency of experimental swine dysentery inoculation strategies
Juan C. Parra-Aguirre, Roman Nosach, Champika Fernando · 2023 · Figshare
Additional file 8 of Identification and profiling of microRNAs during yak’s testicular development
La, Yongfu, Xiaoming Ma, Bao, Pengjia · 2024 · Figshare
Additional file 3 of Evaluation of cerebrospinal fluid levels of synaptic vesicle protein, VAMP-2, across the sporadic Alzheimer’s disease continuum
Julie Goossens, Alba Cervantes González, Nele Dewit, Laia Lidón, Juan Fortea, Daniel Andres Alcolea, Alberto Lleó, Olivia Belbin, Eugeen Vanmechelen · 2024 · Figshare
Additional file 2 of Antiviral activity and mechanism of the antifungal drug, anidulafungin, suggesting its potential to promote treatment of viral diseases
Shen, Shu, Zhang, Yaxian, Zhiyun Yin, Zhu, Qiong, Jingyuan Zhang, Wang, Tiantian, Fang, Yaohui, Xiaoli Wu, Yuan Bai, Shiyu Dai et al. · 2022 · Figshare
Additional file 1 of The dysbiosis of ovine foot microbiome during the development and treatment of contagious ovine digital dermatitis
Duncan, J. S., Joseph William Angell, Richards, P. · 2021 · Figshare
Additional file 1 of Chemopreventive effect of modified zeng-sheng-ping on oral squamous cell carcinoma by regulating tumor associated macrophages through targeting tnf alpha induced protein 6
Wang, Jiaqi, Feiran Lin, Yongxiang Zhou · 2024 · Figshare
Additional file 5 of The effect of the head-up position on cardiopulmonary resuscitation: a systematic review and meta-analysis
Huang, Cheng-Chieh, Chen, Kuan-Chih, Lin, Zih-Yang et al. · 2021 · Figshare
Additional file 2 of The crucial role of locus coeruleus noradrenergic neurons in the interaction between acute sleep disturbance and headache
Li, Bozhi, Ya Cao, Yuan, Huijuan, Yu, Zhe, Shuai Miao, Yang, Chunxiao, Gong, Zihua, Xie, Wei, Li, Chenhao, Bai, Wenhao et al. · 2024 · Figshare
Additional file 1 of Retention and loss of PIT tags and surgically implanted devices in the Eurasian beaver
Mayer, Martin, Marianne Lian, Boris Fuchs · 2022 · Figshare
Additional file 3 of The dysbiosis of ovine foot microbiome during the development and treatment of contagious ovine digital dermatitis
Duncan, J. S., Joseph William Angell, Richards, P. · 2021 · Figshare
Additional file 13 of Inclusion of a dual signal sequence enhances the immunogenicity of a novel viral vectored vaccine against the capsular group B meningococcus
Dylan Sheerin, Christina Dold, Laura Silva-Reyes · 2022 · Figshare
Additional file 1 of Adrenarche-accompanied rise of adrenal sex steroid precursors prevents NAFLD in Young Female rats by converting into active androgens and inactivating hepatic Srebf1 signaling
Haoqing Li, Liu, Yingyu, Fengyan Meng, Chen, Junan, Han, Xingfa · 2024 · Figshare
Additional file 2 of Clustering pattern and evolution characteristic of microRNAs in grass carp (Ctenopharyngodon idella)
Huiqin Niu, Pang, Yifan, Lingli Xie, Qiaozhen Yu, 沈玉帮, Li, Jiale, Xiaoyan Xu · 2023 · Figshare
Additional file 4 of Genome-wide association study reveals the genetic determinism of serum biochemical indicators in ducks
Hehe Tang, Zhang, He, Liu, Dapeng · 2023 · Figshare
Additional file 2 of Comparing the gut microbiota of Sichuan golden monkeys across multiple captive and wild settings: roles of anthropogenic activities and host factors
Xuanzhen Liu, Yu, Jianqiu, Huan, Zongjin, Xu, Mei, Song, Ting, Yang, Ruilin, Zhu, Wei, Jiang, Jianping · 2024 · Figshare
Additional file 4 of Genome-wide identification of quantitative trait loci and candidate genes for seven carcass traits in a four-way intercross porcine population
huiyu wang, Wang, Xiaoyi, Yang, Yongli, Yixuan Zhu, Shuyan Wang, Chen, Qiang, Dawei Yan, Dong, Xinxing, mingli li, Lu, Shaoxiong · 2024 · Figshare
Additional file 13 of Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome
Ruoyang Zhai, Woodys Lenga Ma Bonda, Charlotte Leclaire et al. · 2023 · Figshare
Additional file 5 of Identification of circRNA-associated ceRNA networks in the longissimus dorsi of yak under different feeding systems
Xiaoming Ma, Guo, Xian, Yongfu, La, Wang, Tong, Bao, Pengjia, Min Chu, Wu, Xiaoyun, Yan, Ping, Liang, Chunnian · 2024 · Figshare
Additional file 1 of Integrating genomics and transcriptomics to identify candidate genes for high egg production in Wulong geese (Anser cygnoides orientalis)
Liu, Jingjing, Xiao, Yu, Ren, Pengwei, Shuer Zhang, Liu, Yang, Zhu, Mingxia · 2024 · Figshare
Additional file 1 of The crucial role of locus coeruleus noradrenergic neurons in the interaction between acute sleep disturbance and headache
Li, Bozhi, Ya Cao, Yuan, Huijuan, Yu, Zhe, Shuai Miao, Yang, Chunxiao, Gong, Zihua, Xie, Wei, Li, Chenhao, Wenhao Bai et al. · 2024 · Figshare
Additional file 1 of Preclinical evaluation of [18F]SYN1 and [18F]SYN2, novel radiotracers for PET myocardial perfusion imaging
Seweryn Krajewski, Łukasz Steczek, Karina Gotowicz et al. · 2024 · Figshare
Additional file 1 of Genetic relatedness and diversity of Capillaria species infecting bayad (Bagrus bajad) in upper Egypt
Salwa Mahmoud Abd-Elrahman, Abdel-Rahman, Salma M., Hanaa Y. Bakir · 2024 · Figshare
Additional file 1 of Clustering pattern and evolution characteristic of microRNAs in grass carp (Ctenopharyngodon idella)
Huiqin Niu, Pang, Yifan, Lingli Xie, Qiaozhen Yu, 沈玉帮, Li, Jiale, Xu, Xiaoyan · 2023 · Figshare
Additional file 1 of Weissella confusa F213 ameliorated inflammation and maintained intestinal mucosa integrity in chemically induced colitis rats
I Nengah Sujaya, Ida Ayu Gde Wahyudevi Dharmika, Gede Ngurah Rsi Suwardana, Mariadi, I Ketut, Arijana, I Gusti Kamasan Nyoman, Ida Bagus Oka Winaya, Komang Ayu Nocianitri, Yan Ramona, Fatmawati, Ni Nengah Dwi · 2024 · Figshare
Additional file 1 of Lactate infusion elevates cardiac output through increased heart rate and decreased vascular resistance: a randomised, blinded, crossover trial in a healthy porcine model
Oskar Kjærgaard Hørsdal, Niels Moeslund, Kristoffer Berg Hansen, Roni Ranghoej Nielsen, Møller, Niels, Eiskjær, Hans, Wiggers, Henrik, Nigopan Gopalasingam · 2024 · Figshare
Additional file 1 of TRIM67 alleviates cerebral ischemia‒reperfusion injury by protecting neurons and inhibiting neuroinflammation via targeting IκBα for K63-linked polyubiquitination
Yu, Yongbo, Xia, Qian, Zhan, Gaofeng, Gao, Shuai, Tangrui Han, Meng Mao, Li, Xing, Wang, Yonghong · 2023 · Figshare
Additional file 1 of Pumpkin seed oil: unveiling its potential in controlling inflammation and pathogenicity during experimental trichinellosis
Sara Salah Abdel-Hakeem, Sulaiman Mohammed Alnasser, Meshal, Alotaibi, Mahmoud Abdel-Zaher Abdel-Samiee, Mohamed Salah Eldin Youssef, Elsadek, Shimaa Hamdi Abd, Salwa Mahmoud Abd-Elrahman · 2024 · Figshare
Additional file 1 of Saccharomyces boulardii promoters for control of gene expression in vivo
Carmen Sands, Karl Alex Hedin, Ruben Vazquez-Uribe, Morten Otto Alexander Sommer · 2024 · Figshare
Additional file 1 of RNA-seq coupling two different methods of castration reveals new insights into androgen deficiency-caused degeneration of submaxillary gland in male Sprague Dawley rats
Han, Xingfa, Xia, Xue, Yong Zhuo, Lun Hua, Guozhi Yu, Guixian Bu, Cao, Xiaohan, Xiaogang Du, Qiuxia Liang, Zeng, Xianyin et al. · 2022 · Figshare
Additional file 3 of Genome-wide identification of quantitative trait loci and candidate genes for seven carcass traits in a four-way intercross porcine population
huiyu wang, Wang, Xiaoyi, Yang, Yongli, Yixuan Zhu, Shuyan Wang, Chen, Qiang, Dawei Yan, Dong, Xinxing, mingli li, Lu, Shaoxiong · 2024 · Figshare
Additional file 2 of Adrenarche-accompanied rise of adrenal sex steroid precursors prevents NAFLD in Young Female rats by converting into active androgens and inactivating hepatic Srebf1 signaling
Haoqing Li, Liu, Yingyu, Fengyan Meng, Chen, Junan, Han, Xingfa · 2024 · Figshare
Additional file 7 of The effect of the head-up position on cardiopulmonary resuscitation: a systematic review and meta-analysis
Huang, Cheng-Chieh, Chen, Kuan-Chih, Lin, Zih-Yang et al. · 2021 · Figshare
Additional file 3 of The effect of the head-up position on cardiopulmonary resuscitation: a systematic review and meta-analysis
Huang, Cheng-Chieh, Chen, Kuan-Chih, Lin, Zih-Yang et al. · 2021 · Figshare
Additional file 5 of Genetic relatedness and diversity of Capillaria species infecting bayad (Bagrus bajad) in upper Egypt
Salwa Mahmoud Abd-Elrahman, Abdel-Rahman, Salma M., Hanaa Y. Bakir · 2024 · Figshare
Additional file 9 of Genome-wide association study reveals the genetic determinism of serum biochemical indicators in ducks
Hehe Tang, Zhang, He, Liu, Dapeng · 2023 · Figshare
Additional file 2 of Glycyrrhizin improves the pathogenesis of psoriasis partially through IL-17A and the SIRT1-STAT3 axis
Qiong, Huang, Ling Han, Nanxue Zhang, Chen, Huyan, Yan, Kexiang, Zhang, Zhenghua, Ying Ma, Xu, Jinhua · 2021 · Figshare
Additional file 3 of Oxygenation and ventilation during prolonged experimental cardiopulmonary resuscitation with either continuous or 30:2 compression-to-ventilation ratios together with 10 cmH20 positive end-expiratory pressure
Jukka Kopra, Erik S. Litonius, Pirkka T. Pekkarinen · 2024 · Figshare
Additional file 2 of TRIM67 alleviates cerebral ischemia‒reperfusion injury by protecting neurons and inhibiting neuroinflammation via targeting IκBα for K63-linked polyubiquitination
Yu, Yongbo, Xia, Qian, Zhan, Gaofeng, Shuai Gao, Tangrui Han, Meng Mao, Li, Xing, Wang, Yonghong · 2023 · Figshare
Additional file 1 of Genome-wide association analysis explores the genetic loci of amino acid content in duck’s breast muscle
Wang, Rui, Yinjuan Lu, Jingjing Qi et al. · 2024 · Figshare
Additional file 12 of Identification and profiling of microRNAs during yak’s testicular development
La, Yongfu, Xiaoming Ma, Bao, Pengjia · 2024 · Figshare
Additional file 17 of Inclusion of a dual signal sequence enhances the immunogenicity of a novel viral vectored vaccine against the capsular group B meningococcus
Dylan Sheerin, Christina Dold, Laura Silva-Reyes · 2022 · Figshare
Additional file 2 of Testosterone deficiency promotes arterial stiffening independent of sex chromosome complement
Anil Sakamuri, Bruna Visniauskas, Isabella Kilanowski‐Doroh, Alexandra B. McNally, Ariane Imulinde Sugi, Anne N Kamau, Divya Sengottaian, John A. McLachlan, Montserrat C. Anguera, Franck Mauvais‐Jarvis et al. · 2024 · Figshare
Additional file 4 of Genome-wide association study identifying genetic variants associated with carcass backfat thickness, lean percentage and fat percentage in a four-way crossbred pig population using SLAF-seq technology
huiyu wang, Wang, Xiaoyi, Dawei Yan · 2022 · Figshare
Additional file 5 of Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome
Ruoyang Zhai, Woodys Lenga Ma Bonda, Charlotte Leclaire et al. · 2023 · Figshare
Additional file 2 of Identification and profiling of microRNAs during yak’s testicular development
La, Yongfu, Xiaoming Ma, Bao, Pengjia · 2024 · Figshare
Additional file 2 of Improving the consistency of experimental swine dysentery inoculation strategies
Juan C. Parra-Aguirre, Roman Nosach, Champika Fernando · 2023 · Figshare
Additional file 1 of Evaluation of cerebrospinal fluid levels of synaptic vesicle protein, VAMP-2, across the sporadic Alzheimer’s disease continuum
Julie Goossens, Alba Cervantes González, Nele Dewit, Laia Lidón, Juan Fortea, Daniel Andres Alcolea, Alberto Lleó, Olivia Belbin, Eugeen Vanmechelen · 2024 · Figshare
Additional file 3 of Identification of circRNA-associated ceRNA networks in the longissimus dorsi of yak under different feeding systems
Xiaoming Ma, Guo, Xian, Yongfu, La, Wang, Tong, Bao, Pengjia, Min Chu, Wu, Xiaoyun, Yan, Ping, Liang, Chunnian · 2024 · Figshare
Additional file 9 of Genome-wide identification of quantitative trait loci and candidate genes for seven carcass traits in a four-way intercross porcine population
Wang, Huiyu, Wang, Xiaoyi, Yang, Yongli, Zhu, Yixuan, Shuyan Wang, Chen, Qiang, Dawei Yan, Dong, Xinxing, mingli li, Lu, Shaoxiong · 2024 · Figshare
Additional file 4 of Genetic relatedness and diversity of Capillaria species infecting bayad (Bagrus bajad) in upper Egypt
Salwa Mahmoud Abd-Elrahman, Abdel-Rahman, Salma M., Hanaa Y. Bakir · 2024 · Figshare
Additional file 2 of Chemopreventive effect of modified zeng-sheng-ping on oral squamous cell carcinoma by regulating tumor associated macrophages through targeting tnf alpha induced protein 6
Wang, Jiaqi, Feiran Lin, Yongxiang Zhou · 2024 · Figshare
Additional file 5 of Antiviral activity and mechanism of the antifungal drug, anidulafungin, suggesting its potential to promote treatment of viral diseases
Shen, Shu, Zhang, Yaxian, Zhiyun Yin, Zhu, Qiong, Jingyuan Zhang, Wang, Tiantian, Fang, Yaohui, Xiaoli Wu, Yuan Bai, Shiyu Dai et al. · 2022 · Figshare
Additional file 10 of Genome-wide identification of quantitative trait loci and candidate genes for seven carcass traits in a four-way intercross porcine population
huiyu wang, Wang, Xiaoyi, Yang, Yongli, Yixuan Zhu, Shuyan Wang, Chen, Qiang, Dawei Yan, Dong, Xinxing, mingli li, Lu, Shaoxiong · 2024 · Figshare
Additional file 2 of Identification of circRNA-associated ceRNA networks in the longissimus dorsi of yak under different feeding systems
Xiaoming Ma, Guo, Xian, Yongfu, La, Wang, Tong, Bao, Pengjia, Min Chu, Wu, Xiaoyun, Yan, Ping, Liang, Chunnian · 2024 · Figshare
Additional file 4 of Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome
Ruoyang Zhai, Woodys Lenga Ma Bonda, Charlotte Leclaire et al. · 2023 · Figshare
Additional file 5 of Identification and profiling of microRNAs during yak’s testicular development
La, Yongfu, Xiaoming Ma, Bao, Pengjia · 2024 · Figshare
Additional file 3 of Testosterone deficiency promotes arterial stiffening independent of sex chromosome complement
Anil Sakamuri, Bruna Visniauskas, Isabella Kilanowski‐Doroh, Alexandra B. McNally, Ariane Imulinde Sugi, Anne N Kamau, Divya Sengottaian, John A. McLachlan, Montserrat C. Anguera, Franck Mauvais‐Jarvis et al. · 2024 · Figshare
Additional file 10 of Identification and profiling of microRNAs during yak’s testicular development
La, Yongfu, Xiaoming Ma, Bao, Pengjia · 2024 · Figshare