Dirnagl, Ulrich

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., et al. (2020) · PLOS Biology

Animal testing and alternativesMeta-analysis and systematic reviews

Cited by 5,939

Pathobiology of ischaemic stroke: an integrated view

Dirnagl, U., Iadecola, C., & Moskowitz, M. A. (1999) · Trends in Neurosciences

Acute Ischemic Stroke ManagementNeuroprotection in Cerebral Ischemia

Cited by 3,943

Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

Percie du Sert, N., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., et al. (2020) · PLOS Biology

Animal testing and alternativesMeta-analysis and systematic reviews

Cited by 2,677

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*

Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., et al. (2020) · Journal of Cerebral Blood Flow & Metabolism

Animal testing and alternativesMeta-analysis and systematic reviews

Cited by 1,443

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation

Chamorro, Á., Dirnagl, U., Urra, X., & Planas, A. M. (2016) · The Lancet Neurology

Acute Ischemic Stroke ManagementNeuroprotection in Cerebral Ischemia

Cited by 1,198

Biomedical research: increasing value, reducing waste.

Macleod, M. R., Michie, S., Roberts, I., Dirnagl, U., Chalmers, I., Ioannidis, J. P. A., Salman, R. A.-S., Chan, A.-W., & Glasziou, P. (2014) · The Lancet

Health and Medical Research ImpactsScience, Research, and Medicine

Cited by 1,003

Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment

Priller, J., Flügel, A., Wehner, T., Boentert, M., Haas, C. A., Prinz, M., Fernández-Klett, F., Prass, K., Bechmann, I., de Boer, B. A., et al. (2001) · Nature Medicine

Virus-based gene therapy researchBarrier Structure and Function Studies

Cited by 637

Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain

Fernández-Klett, F., Offenhauser, N., Dirnagl, U., Priller, J., & Lindauer, U. (2010) · Proceedings of the National Academy of Sciences

Barrier Structure and Function StudiesTraumatic Brain Injury and Neurovascular Disturbances

Cited by 399

Good Laboratory Practice: Preventing Introduction of Bias at the Bench

Macleod, M. R., Fisher, M., O'Collins, V., Sena, E. S., Dirnagl, U., Bath, P. M. W., Buchan, A., van der Worp, H. B., Traystman, R., Minematsu, K., et al. (2009) · Stroke

Animal testing and alternativesAcute Ischemic Stroke Management

Cited by 331

Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

Macleod, M. R., van der Worp, H. B., Sena, E. S., Howells, D. W., Dirnagl, U., & Donnan, G. A. (2008) · Stroke

Acute Ischemic Stroke ManagementMeta-analysis and systematic reviews

Cited by 319

Capillary perfusion of the rat brain cortex. An in vivo confocal microscopy study.

Villringer, A., Them, A., Lindauer, U., Einhäupl, K., & Dirnagl, U. (1994) · Circulation Research

Barrier Structure and Function StudiesTraumatic Brain Injury and Neurovascular Disturbances

Cited by 295

Distinguishing between exploratory and confirmatory preclinical research will improve translation

Kimmelman, J., Mogil, J. S., & Dirnagl, U. (2014) · PLoS Biology

Animal testing and alternativesStatistical Methods in Clinical Trials

Cited by 236

The neurovascular unit as a selective barrier to polymorphonuclear granulocyte (PMN) infiltration into the brain after ischemic injury

Enzmann, G., Mysiorek, C., Gorina, R., Cheng, Y.-J., Ghavampour, S., Hannocks, M.-J., Prinz, V., Dirnagl, U., Endres, M., Prinz, M., et al. (2013) · Acta Neuropathologica

Barrier Structure and Function StudiesAcute Ischemic Stroke Management

Cited by 225

Turnover of Rat Brain Perivascular Cells

Bechmann, I., Kwidzinski, E., Kovac, A. D., Simbürger, E., Horvath, T., Gimsa, U., Dirnagl, U., Priller, J., & Nitsch, R. (2001) · Experimental Neurology

Neuroinflammation and Neurodegeneration MechanismsBarrier Structure and Function Studies

Cited by 134

Improved Reperfusion and Neuroprotection by Creatine in a Mouse Model of Stroke

Prass, K., Royl, G., Lindauer, U., Freyer, D., Megow, D., Dirnagl, U., Stöckler-Ipsiroglu, G., Wallimann, T., & Priller, J. (2007) · Journal of Cerebral Blood Flow & Metabolism

Neuroprotection in Cerebral IschemiaAcute Ischemic Stroke Management

Cited by 128

Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke

Holman, C., Piper, S. K., Grittner, U., Diamantaras, A. A., Kimmelman, J., Siegerink, B., & Dirnagl, U. (2016) · PLOS Biology

Animal testing and alternativesMeta-analysis and systematic reviews

Cited by 114

The Gut Microbiome as Therapeutic Target in Central Nervous System Diseases: Implications for Stroke

Winek, K., Dirnagl, U., & Meisel, A. (2016) · Neurotherapeutics

Gut microbiota and healthNeuroinflammation and Neurodegeneration Mechanisms

Cited by 108

Preregistration of exploratory research: Learning from the golden age of discovery

Dirnagl, U. (2020) · PLOS Biology

Academic Publishing and Open AccessMeta-analysis and systematic reviews

Cited by 81

Introduction to the EQIPD quality system

Bespalov, A., Bernard, R., Gilis, A., Gerlach, B., Guillén, J., Castagné, V., Lefevre, I. A., Ducrey, F., Monk, L., Bongiovanni, S., et al. (2021) · eLife

Research Data Management PracticesAnimal testing and alternatives

Cited by 76

Atlas registration for edema-corrected MRI lesion volume in mouse stroke models

Koch, S., Mueller, S., Foddis, M., Bienert, T., von Elverfeldt, D., Knab, F., Farr, T. D., Bernard, R., Dopatka, M., Rex, A., et al. (2019) · Journal of Cerebral Blood Flow & Metabolism

Medical Image Segmentation TechniquesAdvanced MRI Techniques and Applications

Cited by 74

Thomas Willis Lecture: Is Translational Stroke Research Broken, and if So, How Can We Fix It?

Dirnagl, U. (2016) · Stroke

Animal testing and alternativesAcute Ischemic Stroke Management

Cited by 61

Rethinking research reproducibility

Dirnagl, U. (2019) · The EMBO Journal

Academic Publishing and Open AccessScientific Computing and Data Management

Cited by 35

Quality management for academic laboratories: burden or boon?: Professional quality management could be very beneficial for academic research but needs to overcome specific caveats

Dirnagl, U., Kurreck, C., Castaños‐Vélez, E., & Bernard, R. (2018) · The EMBO Reports

Management Systems and Quality ImprovementQuality and Management Systems

Cited by 35

Introducing quality measures in an academic research consortium: Lessons and recommendation from implementing an ad hoc quality management system for organ model research

Hülsemann, M., Wiebach, J., Drude, N. I., Kniffert, S., Behm, L., Hönzke, K., Baumgardt, M., Hippenstiel, S., Hocke, A. C., Dirnagl, U., et al. (2022) · The EMBO Reports

Research Data Management PracticesAcademic Publishing and Open Access

Cited by 6