Howells, David W.

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research

Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., et al. (2020) · PLOS Biology

Animal testing and alternativesMeta-analysis and systematic reviews

Cited by 5,939

Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0

Percie du Sert, N., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., Emerson, M., et al. (2020) · PLOS Biology

Animal testing and alternativesMeta-analysis and systematic reviews

Cited by 2,677

The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research*

Percie du Sert, N., Hurst, V., Ahluwalia, A., Alam, S., Avey, M. T., Baker, M., Browne, W. J., Clark, A., Cuthill, I. C., Dirnagl, U., et al. (2020) · Journal of Cerebral Blood Flow & Metabolism

Animal testing and alternativesMeta-analysis and systematic reviews

Cited by 1,443

How to increase value and reduce waste when research priorities are set

Chalmers, I., Bracken, M. B., Djulbegovic, B., Garattini, S., Grant, J., Gülmezoglu, A. M., Howells, D. W., Ioannidis, J. P. A., & Oliver, S. (2014) · The Lancet

Health and Medical Research ImpactsResearch, Science, and Academia

Cited by 1,436

Can Animal Models of Disease Reliably Inform Human Studies?

van der Worp, H. B., Howells, D. W., Sena, E. S., Porritt, M. J., Rewell, S., O'Collins, V., & Macleod, M. R. (2010) · PLoS Medicine

Animal testing and alternativesBiomedical Ethics and Regulation

Cited by 1,354

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

Fisher, M., Feuerstein, G., Howells, D. W., Hurn, P. D., Kent, T. A., Savitz, S. I., & Lo, E. H. (2009) · Stroke

Acute Ischemic Stroke ManagementAnimal testing and alternatives

Cited by 1,352

A call for transparent reporting to optimize the predictive value of preclinical research

Landis, S. C., Amara, S. G., Asadullah, K., Austin, C. P., Blumenstein, R., Bradley, E. W., Crystal, R. G., Darnell, R. B., Ferrante, R. J., Fillit, H., et al. (2012) · Nature

Animal testing and alternativesMeta-analysis and systematic reviews

Cited by 1,196

Publication bias in reports of animal stroke studies leads to major overstatement of efficacy

Sena, E. S., van der Worp, H. B., Bath, P. M. W., Howells, D. W., & Macleod, M. R. (2010) · PLoS Biology

Meta-analysis and systematic reviewsAcademic Publishing and Open Access

Cited by 600

Reduced BDNF mRNA Expression in the Parkinson's Disease Substantia Nigra

Howells, D. W., Porritt, M. J., Wong, J. Y. F., Batchelor, P. E., Kalnins, R., Hughes, A. J., & Donnan, G. A. (2000) · Experimental Neurology

Parkinson's Disease Mechanisms and TreatmentsNerve injury and regeneration

Cited by 513

Pericytes and Neurovascular Function in the Healthy and Diseased Brain

Brown, L. S., Foster, C. G., Courtney, J.-M., King, N. E., Howells, D. W., & Sutherland, B. A. (2019) · Frontiers in Cellular Neuroscience

Barrier Structure and Function StudiesAngiogenesis and VEGF in Cancer

Cited by 406

Risk of bias in reports of in vivo research: a focus for improvement

Macleod, M. R., Lawson McLean, A., Kyriakopoulou, A., Serghiou, S., de Wilde, A., Sherratt, N., Hirst, T., Hemblade, R., Bahor, Z., Nunes-Fonseca, C., et al. (2015) · PLOS Biology

Meta-analysis and systematic reviewsAcademic Publishing and Open Access

Cited by 358

Good Laboratory Practice: Preventing Introduction of Bias at the Bench

Macleod, M. R., Fisher, M., O'Collins, V., Sena, E. S., Dirnagl, U., Bath, P. M. W., Buchan, A., van der Worp, H. B., Traystman, R., Minematsu, K., et al. (2009) · Stroke

Animal testing and alternativesAcute Ischemic Stroke Management

Cited by 331

Evidence for the Efficacy of NXY-059 in Experimental Focal Cerebral Ischaemia Is Confounded by Study Quality

Macleod, M. R., van der Worp, H. B., Sena, E. S., Howells, D. W., Dirnagl, U., & Donnan, G. A. (2008) · Stroke

Acute Ischemic Stroke ManagementMeta-analysis and systematic reviews

Cited by 319

Different Strokes for Different Folks: The Rich Diversity of Animal Models of Focal Cerebral Ischemia

Howells, D. W., Porritt, M. J., Rewell, S. S., O'Collins, V., Sena, E. S., van der Worp, H. B., Traystman, R. J., & Macleod, M. R. (2010) · Journal of Cerebral Blood Flow & Metabolism

Acute Ischemic Stroke ManagementNeurological Disease Mechanisms and Treatments

Cited by 309

Evaluation of excess significance bias in animal studies of neurological diseases

Tsilidis, K. K., Panagiotou, O. A., Sena, E. S., Aretouli, E., Evangelou, E., Howells, D. W., Salman, R. A.-S., Macleod, M. R., & Ioannidis, J. P. A. (2013) · PLoS Biology

Meta-analysis and systematic reviewsAnimal testing and alternatives

Cited by 295

Systematic reviews and meta-analysis of preclinical studies: why perform them and how to appraise them critically

Sena, E. S., Currie, G. L., McCann, S. K., Macleod, M. R., & Howells, D. W. (2014) · Journal of Cerebral Blood Flow & Metabolism

Meta-analysis and systematic reviewsMethodologies in Health Research and Practice

Cited by 264

Prespecified dose-response analysis for A Very Early Rehabilitation Trial (AVERT)

Bernhardt, J., Churilov, L., Ellery, F., Collier, J., Chamberlain, J., Langhorne, P., Lindley, R. I., Moodie, M., Dewey, H., Thrift, A. G., et al. (2016) · Neurology

Stroke Rehabilitation and RecoveryAcute Ischemic Stroke Management

Cited by 221

Inhibiting BDNF expression by antisense oligonucleotide infusion causes loss of nigral dopaminergic neurons

Porritt, M. J., Batchelor, P. E., & Howells, D. W. (2005) · Experimental Neurology

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 135

Bringing rigour to translational medicine

Howells, D. W., Sena, E. S., & Macleod, M. R. (2014) · Nature Reviews Neurology

Animal testing and alternativesHealth and Medical Research Impacts

Cited by 130

Exercise Reduces Infarct Volume and Facilitates Neurobehavioral Recovery: Results From a Systematic Review and Meta-analysis of Exercise in Experimental Models of Focal Ischemia

Egan, K. J., Janssen, H., Sena, E. S., Longley, L., Speare, S., Howells, D. W., Spratt, N. J., Macleod, M. R., Mead, G. E., & Bernhardt, J. (2014) · Neurorehabilitation and Neural Repair

Stroke Rehabilitation and RecoveryAcute Ischemic Stroke Management

Cited by 49

Modeling Risk Factors and Confounding Effects in Stroke

McColl, B., Howells, D., Rothwell, N., & Denes, A. (2010) · Neuromethods

Acute Ischemic Stroke ManagementNeurological Disease Mechanisms and Treatments

Cited by 3