The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
The Dynamics of Human Body Weight Change
Open accessAbstract
An imbalance between energy intake and energy expenditure will lead to a change in body weight (mass) and body composition (fat and lean masses). A quantitative understanding of the processes involved, which currently remains lacking, will be useful in determining the etiology and treatment of obesity and other conditions resulting from prolonged energy imbalance. Here, we show that a mathematical model of the macronutrient flux balances can capture the long-term dynamics of human weight change; all previous models are special cases of this model. We show that the generic dynamic behavior of body composition for a clamped diet can be divided into two classes. In the first class, the body composition and mass are determined uniquely. In the second class, the body composition can exist at an infinite number of possible states. Surprisingly, perturbations of dietary energy intake or energy expenditure can give identical responses in both model classes, and existing data are insufficient to distinguish between these two possibilities. Nevertheless, this distinction has important implications for the efficacy of clinical interventions that alter body composition and mass.
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“The integrated systems by which the brain and body communicate to regulate body weight may indicate single or multiple set-points for weight that may be difficult to adjust 12,19–21.”
From Cellular bioenergetics as a target for obesity therapy (2010) · cites this paper as [21]
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Nonlinear Oscillations, Dynamical Systems, and Bifurcations of Vector Fields
Guckenheimer, J., & Holmes, P. (1983) · Applied Mathematical Sciences · doi:10.1007/978-1-4612-1140-2 · Cited by 16,144
Nonlinear Dynamics and Chaos: With Applications to Physics, Biology, Chemistry, and Engineering
Strogatz, S. H., Friedman, M. J., Mallinckrodt, A. J., & McKay, S. R. (1994) · Computers in Physics · doi:10.1063/1.4823332 · Cited by 4,654
Strogatz, S. H. (1998) · doi:10.1142/3481 · Cited by 4,542
Nonlinear Dynamics and Chaos: With Applications to Physics, Biology, Chemistry and Engineering
Strogatz, S. H., & Fox, R. F. (1995) · Physics Today · doi:10.1063/1.2807947 · Cited by 2,584
Obesity and the Environment: Where Do We Go from Here?
Hill, J. O., Wyatt, H. R., Reed, G. W., & Peters, J. C. (2003) · Science · doi:10.1126/science.1079857 · Cited by 2,180
THE BIOLOGY OF HUMAN STARVATION
Keys, A., BROŽEK, J., & Henschel, A. (1951) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1951.tb56499.x · Cited by 2,135
The Biology of Human Starvation: Volume I
KEYS, A., BROŽEK, J., HENSCHEL, A., MICKELSEN, O., & TAYLOR, H. L. (1950) · doi:10.5749/j.ctv9b2tqv · Cited by 2,039
Changes in Energy Expenditure Resulting from Altered Body Weight
Leibel, R. L., Rosenbaum, M., & Hirsch, J. (1995) · New England Journal of Medicine · doi:10.1056/nejm199503093321001 · Cited by 2,012
Report of the task group on reference man
(1979) · Annals of the ICRP · doi:10.1016/0146-6453(79)90123-4 · Cited by 1,715
Nonlinear oscillations, dynamical systems, and bifurcations of vector fields
Cowan, J. D. (1986) · Mathematical Biosciences · doi:10.1016/0025-5564(86)90154-9 · Cited by 1,080
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Research works printed but not linked: 2
- K Hall, 2002, Can a temporary high fat diet cause persistent obesity via acquired leptin resistance? Insights from a mathematical model., Diabetes, 51(S2), A607
- L Girardier, 1994, [autoregulation of body weight and body composition in man. a systematic approach through models and simulation]., Arch Int Physiol Biochim Biophys, 102, A23
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Quantification of the effect of energy imbalance on bodyweight
Hall, K. D., Sacks, G., Chandramohan, D., Chow, C. C., Wang, Y. C., Gortmaker, S. L., & Swinburn, B. A. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60812-x · Cited by 1,165
Self-citationCellular bioenergetics as a target for obesity therapy
Tseng, Y.-H., Cypess, A. M., & Kahn, C. R. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3138 · Cited by 591
Thomas, D. M., Bouchard, C., Church, T., Slentz, C., Kraus, W. E., Redman, L. M., Martin, C. K., Silva, A. M., Vossen, M., Westerterp, K., et al. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01012.x · Cited by 280
Changes in energy expenditure with weight gain and weight loss in humans
Müller, M. J., Enderle, J., & Bosy-Westphal, A. (2016) · Current Obesity Reports · doi:10.1007/s13679-016-0237-4 · Cited by 267
Blundell, J. E., Caudwell, P., Gibbons, C., Hopkins, M., Näslund, E., King, N. A., & Finlayson, G. (2012) · British Journal of Nutrition · doi:10.1017/s0007114511003138 · Cited by 225
Metadata
- Authors
- Chow, C. C., & Hall, K. D.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Chow, Carson C.
- Venue
- PLoS Computational Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-03-28
- Volume
- 4
- Issue
- 3
- Pages
- e1000045
- ISSN
- 1553-734X (ISSN-L)
- 1553-7358
- PMC
- PMC2266991
- OpenAlex
- W2103014115
- Cited by
- 156
- References
- 51
- Citations by year
- 2026: 9 · 2025: 5 · 2024: 13 · 2023: 3 · 2022: 7 · 2021: 7 · 2020: 2 · 2019: 12 · 2018: 4 · 2017: 9 · 2016: 9 · 2015: 6 · 2014: 13 · 2013: 8 · 2012: 12
- FWCI
- 5.48
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Computational Biology (publishedVersion, public-domain)
- PubMed Central (publishedVersion, public-domain)
- PubMed (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- arXiv (Cornell University) (public-domain)
- Funders
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
- Keywords
- weight change, energy balance, energy expenditure, body composition, fat mass, lean body mass, obesity, mathematical model, dynamical systems, multiple steady states, energy intake
- MeSH terms
- Body Composition, Computer Simulation, Eating, Energy Metabolism, Humans, Kinetics, Models, Biological, Obesity, Weight Gain, Weight Loss
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