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Identification of a Functional Connectome for Long-Term Fear Memory in Mice

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Wheeler, Anne L., Teixeira, Cátia M., Wang, Afra H., Xiong, Xuejian, Kovacevic, Natasa, Lerch, Jason P., McIntosh, Anthony R., Parkinson, John, Frankland, Paul W.·2013·PLoS Computational Biology

DOI 10.1371/journal.pcbi.1002853PMC PMC3536620

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Abstract

Long-term memories are thought to depend upon the coordinated activation of a broad network of cortical and subcortical brain regions. However, the distributed nature of this representation has made it challenging to define the neural elements of the memory trace, and lesion and electrophysiological approaches provide only a narrow window into what is appreciated a much more global network. Here we used a global mapping approach to identify networks of brain regions activated following recall of long-term fear memories in mice. Analysis of Fos expression across 84 brain regions allowed us to identify regions that were co-active following memory recall. These analyses revealed that the functional organization of long-term fear memories depends on memory age and is altered in mutant mice that exhibit premature forgetting. Most importantly, these analyses indicate that long-term memory recall engages a network that has a distinct thalamic-hippocampal-cortical signature. This network is concurrently integrated and segregated and therefore has small-world properties, and contains hub-like regions in the prefrontal cortex and thalamus that may play privileged roles in memory expression.

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Authors: Wheeler, A. L., Teixeira, C. M., Wang, A. H., Xiong, X., Kovacevic, N., Lerch, J. P., McIntosh, A. R., Parkinson, J., & Frankland, P. W.
Affiliations: University of Toronto (CA)
Hospital for Sick Children (CA)
Baycrest Hospital (CA)
Corresponding author: Frankland, Paul W.
ORCID: Wheeler, Anne L.
Teixeira, Cátia M.
Lerch, Jason P.
McIntosh, Anthony R.
Parkinson, John
Frankland, Paul W.
Venue: PLoS Computational Biology
Publisher: Public Library of Science (PLoS)
Published: 2013-01-03
Volume: 9
Issue: 1
Pages: e1002853
ISSN: 1553-734X (ISSN-L)
1553-7358
DOI: 10.1371/journal.pcbi.1002853
PMC: PMC3536620
OpenAlex: W1995227930
Cited by: 315
References: 76
Citations by year: 2026: 20 · 2025: 30 · 2024: 31 · 2023: 42 · 2022: 33 · 2021: 36 · 2020: 20 · 2019: 22 · 2018: 21 · 2017: 24 · 2016: 6 · 2015: 11 · 2014: 13 · 2013: 5
FWCI: 6.37
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS Computational Biology (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: Hospital for Sick Children
Canadian Institutes of Health Research (82940_1, MOP77561, 82940)
Fundação para a Ciência e a Tecnologia
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: memory retrieval, functional connectome, Fos expression, memory age, thalamus, hippocampus, prefrontal cortex, small-world networks, hub regions, memory traces, mice
MeSH terms: Animals, Brain, Fear, Immunohistochemistry, Memory, Mice, Mutant Strains, Nerve Net, Mice

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Identification of a Functional Connectome for Long-Term Fear Memory in Mice

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