The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Glucocorticoid Receptor-Dependent Gene Regulatory Networks
Open accessAbstract
While the molecular mechanisms of glucocorticoid regulation of transcription have been studied in detail, the global networks regulated by the glucocorticoid receptor (GR) remain unknown. To address this question, we performed an orthogonal analysis to identify direct targets of the GR. First, we analyzed the expression profile of mouse livers in the presence or absence of exogenous glucocorticoid, resulting in over 1,300 differentially expressed genes. We then executed genome-wide location analysis on chromatin from the same livers, identifying more than 300 promoters that are bound by the GR. Intersecting the two lists yielded 53 genes whose expression is functionally dependent upon the ligand-bound GR. Further network and sequence analysis of the functional targets enabled us to suggest interactions between the GR and other transcription factors at specific target genes. Together, our results further our understanding of the GR and its targets, and provide the basis for more targeted glucocorticoid therapies.
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Cites
Transcriptional Regulatory Networks in Saccharomyces cerevisiae
Lee, T. I., Rinaldi, N. J., Robert, F., Odom, D. T., Bar-Joseph, Z., Gerber, G. K., Hannett, N. M., Harbison, C. T., Thompson, C. M., Simon, I., et al. (2002) · Science · doi:10.1126/science.1075090 · Cited by 2,956
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REGULATION OF PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP) GENE EXPRESSION
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Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells
Galon, J., Franchimont, D., Hiroi, N., Frey, G., Boettner, A., Ehrhart-Bornstein, M., O’shea, J. J., Chrousos, G. P., & Bornstein, S. R. (2002) · The FASEB Journal · doi:10.1096/fj.01-0245com · Cited by 606 · cited 1×
“To better understand glucocorticoid signaling, RNA expression profiling after glucocorticoid administration has been performed by several groups [11–16].”
MethodAccuracy and calibration of commercial oligonucleotide and custom cDNA microarrays
Yuen, T. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.10.e48 · Cited by 520
Vidal, N., Brandstrom, H., Jonsson, K., & Ohlsson, C. (1998) · Journal of Endocrinology · doi:10.1677/joe.0.1590191 · Cited by 185
Adrenomedullin is a potent stimulator of osteoblastic activity in vitro and in vivo
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Cited by
Glucocorticoids, metabolism and metabolic diseases
Vegiopoulos, A., & Herzig, S. (2007) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2007.05.015 · Cited by 535
Establishment of Intestinal Identity and Epithelial-Mesenchymal Signaling by Cdx2
Gao, N., White, P., & Kaestner, K. H. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.010 · Cited by 381
Self-citationDeterminants of Cell- and Gene-Specific Transcriptional Regulation by the Glucocorticoid Receptor
So, A. Y.-L., Chaivorapol, C., Bolton, E. C., Li, H., & Yamamoto, K. R. (2007) · PLoS Genetics · doi:10.1371/journal.pgen.0030094 · Cited by 305
Lawrence, M. G., Lai, J., & Clements, J. A. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0034 · Cited by 265
Defeat stress in rodents: from behavior to molecules
Hammels, C., Pishva, E., De Vry, J., van den Hove, D. L. A., Prickaerts, J., van Winkel, R., Selten, J.-P., Lesch, K.-P., Daskalakis, N. P., Steinbusch, H. W. M., et al. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.10.006 · Cited by 230
Metadata
- Authors
- Phuc Le, P., Friedman, J. R., Schug, J., Brestelli, J. E., Parker, J. B., Bochkis, I. M., & Kaestner, K. H.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2005-08-05
- Volume
- 1
- Issue
- 2
- Pages
- e16
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2117409112
- Cited by
- 250
- References
- 8
- FWCI
- 6.05
- Type
- journal article
- Language
- en
- Open access
- gold
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- Phuc Le, P., Friedman, J. R., Schug, J., Brestelli, J. E., Parker, J. B., Bochkis, I. M., & Kaestner, K. H. (2005). Glucocorticoid Receptor-Dependent Gene Regulatory Networks. PLoS Genetics. https://doi.org/10.1371/journal.pgen.0010016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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