The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Genetic Analysis of the Capsular Biosynthetic Locus from All 90 Pneumococcal Serotypes
Open accessAbstract
Several major invasive bacterial pathogens are encapsulated. Expression of a polysaccharide capsule is essential for survival in the blood, and thus for virulence, but also is a target for host antibodies and the basis for effective vaccines. Encapsulated species typically exhibit antigenic variation and express one of a number of immunochemically distinct capsular polysaccharides that define serotypes. We provide the sequences of the capsular biosynthetic genes of all 90 serotypes of Streptococcus pneumoniae and relate these to the known polysaccharide structures and patterns of immunological reactivity of typing sera, thereby providing the most complete understanding of the genetics and origins of bacterial polysaccharide diversity, laying the foundations for molecular serotyping. This is the first time, to our knowledge, that a complete repertoire of capsular biosynthetic genes has been available, enabling a holistic analysis of a bacterial polysaccharide biosynthesis system. Remarkably, the total size of alternative coding DNA at this one locus exceeds 1.8 Mbp, almost equivalent to the entire S. pneumoniae chromosomal complement.
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Cited by
Pneumococcal Capsules and Their Types: Past, Present, and Future
Geno, K. A., Gilbert, G. L., Song, J. Y., Skovsted, I. C., Klugman, K. P., Jones, C., Konradsen, H. B., & Nahm, M. H. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00024-15 · Cited by 732
Self-citationSecondary bacterial infections associated with influenza pandemics
Morris, D. E., Cleary, D. W., & Clarke, S. C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01041 · Cited by 576
Cell Wall Structure and Function in Lactic Acid Bacteria
Chapot-Chartier, M.-P., & Kulakauskas, S. (2014) · Microbial Cell Factories · doi:10.1186/1475-2859-13-s1-s9 · Cited by 410
Caggianiello, G., Kleerebezem, M., & Spano, G. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7471-2 · Cited by 396
Polysaccharide Production by Lactic Acid Bacteria: From Genes to Industrial Applications
Zeidan, A. A., Poulsen, V. K., Janzen, T., Buldo, P., Derkx, P. M. F., Øregaard, G., & Neves, A. R. (2017) · FEMS Microbiology Reviews · doi:10.1093/femsre/fux017 · Cited by 326
Metadata
- Authors
- Bentley, S. D., Aanensen, D. M., Mavroidi, A., Saunders, D., Rabbinowitsch, E., Collins, M., Donohoe, K., Harris, D., Murphy, L., Quail, M. A., Samuel, G., Skovsted, I. C., Kaltoft, M. S., Barrell, B., Reeves, P. R., Parkhill, J., & Spratt, B. G.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2006-03-10
- Volume
- 2
- Issue
- 3
- Pages
- e31
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2023964275
- Cited by
- 759
- References
- 42
- FWCI
- 21.47
- Type
- journal article
- Language
- en
- Open access
- gold
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- Bentley, S. D., Aanensen, D. M., Mavroidi, A., Saunders, D., Rabbinowitsch, E., Collins, M., Donohoe, K., Harris, D., Murphy, L., Quail, M. A., Samuel, G., Skovsted, I. C., Kaltoft, M. S., Barrell, B., Reeves, P. R., Parkhill, J., & Spratt, B. G. (2006). Genetic Analysis of the Capsular Biosynthetic Locus from All 90 Pneumococcal Serotypes. PLoS Genetics. https://doi.org/10.1371/journal.pgen.0020031
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