The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Mapping Determinants of Gene Expression Plasticity by Genetical Genomics in C. elegans
Open accessAbstract
Recent genetical genomics studies have provided intimate views on gene regulatory networks. Gene expression variations between genetically different individuals have been mapped to the causal regulatory regions, termed expression quantitative trait loci. Whether the environment-induced plastic response of gene expression also shows heritable difference has not yet been studied. Here we show that differential expression induced by temperatures of 16 degrees C and 24 degrees C has a strong genetic component in Caenorhabditis elegans recombinant inbred strains derived from a cross between strains CB4856 (Hawaii) and N2 (Bristol). No less than 59% of 308 trans-acting genes showed a significant eQTL-by-environment interaction, here termed plasticity quantitative trait loci. In contrast, only 8% of an estimated 188 cis-acting genes showed such interaction. This indicates that heritable differences in plastic responses of gene expression are largely regulated in trans. This regulation is spread over many different regulators. However, for one group of trans-genes we found prominent evidence for a common master regulator: a transband of 66 coregulated genes appeared at 24 degrees C. Our results suggest widespread genetic variation of differential expression responses to environmental impacts and demonstrate the potential of genetical genomics for mapping the molecular determinants of phenotypic plasticity.
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Maere, S., Heymans, K., & Kuiper, M. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti551 · Cited by 4,155
Roff, D. (2001) · Encyclopedia of Biodiversity · doi:10.1016/b0-12-226865-2/00175-9 · Cited by 2,039
Genetics of gene expression surveyed in maize, mouse and man
Schadt, E. E., Monks, S. A., Drake, T. A., Lusis, A. J., Che, N., Colinayo, V., Ruff, T. G., Milligan, S. B., Lamb, J. R., Cavet, G., et al. (2003) · Nature · doi:10.1038/nature01434 · Cited by 1,503
Genetic Dissection of Transcriptional Regulation in Budding Yeast
Brem, R. B., Yvert, G., Clinton, R., & Kruglyak, L. (2002) · Science · doi:10.1126/science.1069516 · Cited by 1,390
Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer
Hughes, T. R., Mao, M., Jones, A. R., Burchard, J., Marton, M. J., Shannon, K. W., Lefkowitz, S. M., Ziman, M., Schelter, J. M., Meyer, M. R., et al. (2001) · Nature Biotechnology · doi:10.1038/86730 · Cited by 1,298
Phenotypic plasticity and evolution by genetic assimilation
Pigliucci, M., Murren, C. J., & Schlichting, C. D. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.02070 · Cited by 1,122
Genetical genomics: the added value from segregation
Jansen, R. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02310-1 · Cited by 1,008
Self-citationGenomic analysis of regulatory network dynamics reveals large topological changes
Luscombe, N. M., Madan Babu, M., Yu, H., Snyder, M., Teichmann, S. A., & Gerstein, M. (2004) · Nature · doi:10.1038/nature02782 · Cited by 973
de Bono, M., & Bargmann, C. I. (1998) · Cell · doi:10.1016/s0092-8674(00)81609-8 · Cited by 812
A Gene Expression Map for Caenorhabditis elegans
Kim, S. K., Lund, J., Kiraly, M., Duke, K., Jiang, M., Stuart, J. M., Eizinger, A., Wylie, B. N., & Davidson, G. S. (2001) · Science · doi:10.1126/science.1061603 · Cited by 658
Cited by
The role of regulatory variation in complex traits and disease
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Mapping complex disease traits with global gene expression
Cookson, W., Liang, L., Abecasis, G., Moffatt, M., & Lathrop, M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2537 · Cited by 849
Des Marais, D. L., Hernandez, K. M., & Juenger, T. E. (2013) · Annual Review of Ecology, Evolution, and Systematics · doi:10.1146/annurev-ecolsys-110512-135806 · Cited by 455
Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells
Lee, M. N., Ye, C., Villani, A.-C., Raj, T., Li, W., Eisenhaure, T. M., Imboywa, S. H., Chipendo, P. I., Ran, F. A., Slowikowski, K., et al. (2014) · Science · doi:10.1126/science.1246980 · Cited by 442
Gene–Environment Interaction in Yeast Gene Expression
Smith, E. N., & Kruglyak, L. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060083 · Cited by 391
Metadata
- Authors
- Li, Y., Álvarez, O. A., Gutteling, E. W., Tijsterman, M., Fu, J., Riksen, J. A. G., Hazendonk, E., Prins, P., Plasterk, R. H. A., Jansen, R. C., Breitling, R., & Kammenga, J. E.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2006
- Volume
- 2
- Issue
- 12
- Pages
- e222
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W1974821552
- Cited by
- 269
- References
- 34
- FWCI
- 9.54
- Type
- journal article
- Language
- en
- Open access
- gold
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- Li, Y., Álvarez, O. A., Gutteling, E. W., Tijsterman, M., Fu, J., Riksen, J. A. G., Hazendonk, E., Prins, P., Plasterk, R. H. A., Jansen, R. C., Breitling, R., & Kammenga, J. E. (2006). Mapping Determinants of Gene Expression Plasticity by Genetical Genomics in C. elegans. PLoS Genetics. https://doi.org/10.1371/journal.pgen.0020222
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