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Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

Lee, Mark N., Ye, Chun, Villani, Alexandra-Chloé, Raj, Towfique, Li, Weibo, Eisenhaure, Thomas M., Imboywa, Selina H., Chipendo, Portia I. +16 more·2014·Science
DOI 10.1126/science.1246980PMC PMC4124741
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Abstract

Immune Variation: It is difficult to determine the mechanistic consequences of context-dependent genetic variants, some of which may be related to disease (see the Perspective by Gregersen ). Two studies now report on the effects of stimulating immunological monocytes and dendritic cells with proteins that can elicit a response to bacterial or viral infection and assess the functional links between genetic variants and profiles of gene expression. M. N. Lee et al. ( 10.1126/science.1246980 ) analyzed the expression of more than 400 genes, in dendritic cells from 534 healthy subjects, which revealed how expression quantitative trait loci (eQTLs) affect gene expression within the interferon-β and the Toll-like receptor 3 and 4 pathways. Fairfax et al. ( 10.1126/science.1246949 ) performed a genome-wide analysis to show that many eQTLs affected monocyte gene expression in a stimulus- or time-specific manner.

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Authors
Lee, M. N., Ye, C., Villani, A.-C., Raj, T., Li, W., Eisenhaure, T. M., Imboywa, S. H., Chipendo, P. I., Ran, F. A., Slowikowski, K., Ward, L. D., Raddassi, K., McCabe, C., Lee, M. H., Frohlich, I. Y., Hafler, D. A., Kellis, M., Raychaudhuri, S., Zhang, F., Stranger, B. E., Benoist, C. O., De Jager, P. L., Regev, A., & Hacohen, N.
Affiliations
  • Broad Institute of Massachusetts Institute of Technology (MIT) and Harvard, Cambridge, MA 02142, USA.
  • Harvard Medical School, Boston, MA 02115, USA.
  • Bioinformatics and Integrative Genomics, Graduate School of Arts and Sciences, Harvard University, Cambridge, MA 02138, USA.
  • Department of Neurology, Yale School of Medicine, New Haven, CT 06511, USA.
  • Department of Biological Engineering, MIT, Cambridge, MA 02139, USA.
  • McGovern Institute for Brain Research, MIT, Cambridge, MA 02139, USA.
  • Section of Genetic Medicine, The University of Chicago, Chicago, IL 60637, USA.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2014-03-07
Volume
343
Issue
6175
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1246980
PMC
PMC4124741
Cited by
441
References
8
Language
en

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