Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 169

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels

Open access
Richards, J. Brent, Waterworth, Dawn, O'Rahilly, Stephen, Hivert, Marie-France, Loos, Ruth J. F., Perry, John R. B., Tanaka, Toshiko, Timpson, Nicholas John, Semple, Robert K., Soranzo, Nicole, Song, Kijoung, Rocha, Nuno, Grundberg, Elin, Dupuis, Josée, Florez, Jose C., Langenberg, Claudia, Prokopenko, Inga, Saxena, Richa, Sladek, Robert, Aulchenko, Yurii, Evans, David, Waeber, Gerard, Erdmann, Jeanette, Burnett, Mary-Susan, Sattar, Naveed, Devaney, Joseph, Willenborg, Christina, Hingorani, Aroon, Witteman, Jaquelin C. M., Vollenweider, Peter, Glaser, Beate, Hengstenberg, Christian, Ferrucci, Luigi, Melzer, David, Stark, Klaus, Deanfield, John, Winogradow, Janina, Grassl, Martina, Hall, Alistair S., Egan, Josephine M., Thompson, John R., Ricketts, Sally L., König, Inke R., Reinhard, Wibke, Grundy, Scott, Wichmann, H-Erich, Barter, Phil, Mahley, Robert, Kesaniemi, Y. Antero, Rader, Daniel J., Reilly, Muredach P., Epstein, Stephen E., Stewart, Alexandre F. R., Van Duijn, Cornelia M., Schunkert, Heribert, Burling, Keith, Deloukas, Panos, Pastinen, Tomi, Samani, Nilesh J., McPherson, Ruth, Davey Smith, George, Frayling, Timothy M., Wareham, Nicholas J., Meigs, James B., Mooser, Vincent, Spector, Tim D., GIANT Consortium·2009·PLoS Genetics
DOI 10.1371/journal.pgen.1000768
Open this paper in CoChat — free account

Abstract

The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD). We meta-analyzed 3 genome-wide association studies for circulating adiponectin levels (n = 8,531) and sought validation of the lead single nucleotide polymorphisms (SNPs) in 5 additional cohorts (n = 6,202). Five SNPs were genome-wide significant in their relationship with adiponectin (P< or =5x10(-8)). We then tested whether these 5 SNPs were associated with risk of T2D and CHD using a Bonferroni-corrected threshold of P< or =0.011 to declare statistical significance for these disease associations. SNPs at the adiponectin-encoding ADIPOQ locus demonstrated the strongest associations with adiponectin levels (P-combined = 9.2x10(-19) for lead SNP, rs266717, n = 14,733). A novel variant in the ARL15 (ADP-ribosylation factor-like 15) gene was associated with lower circulating levels of adiponectin (rs4311394-G, P-combined = 2.9x10(-8), n = 14,733). This same risk allele at ARL15 was also associated with a higher risk of CHD (odds ratio [OR] = 1.12, P = 8.5x10(-6), n = 22,421) more nominally, an increased risk of T2D (OR = 1.11, P = 3.2x10(-3), n = 10,128), and several metabolic traits. Expression studies in humans indicated that ARL15 is well-expressed in skeletal muscle. These findings identify a novel protein, ARL15, which influences circulating adiponectin levels and may impact upon CHD risk.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1371/journal.pgen.1000768

Cites

12 of 12 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 12 references

Cited by

See all 169

Metadata

Authors
Richards, J. B., Waterworth, D., O'Rahilly, S., Hivert, M.-F., Loos, R. J. F., Perry, J. R. B., Tanaka, T., Timpson, N. J., Semple, R. K., Soranzo, N., Song, K., Rocha, N., Grundberg, E., Dupuis, J., Florez, J. C., Langenberg, C., Prokopenko, I., Saxena, R., Sladek, R., Aulchenko, Y., Evans, D., Waeber, G., Erdmann, J., Burnett, M.-S., Sattar, N., Devaney, J., Willenborg, C., Hingorani, A., Witteman, J. C. M., Vollenweider, P., Glaser, B., Hengstenberg, C., Ferrucci, L., Melzer, D., Stark, K., Deanfield, J., Winogradow, J., Grassl, M., Hall, A. S., Egan, J. M., Thompson, J. R., Ricketts, S. L., König, I. R., Reinhard, W., Grundy, S., Wichmann, H.-E., Barter, P., Mahley, R., Kesaniemi, Y. A., Rader, D. J., Reilly, M. P., Epstein, S. E., Stewart, A. F. R., Van Duijn, C. M., Schunkert, H., Burling, K., Deloukas, P., Pastinen, T., Samani, N. J., McPherson, R., Davey Smith, G., Frayling, T. M., Wareham, N. J., Meigs, J. B., Mooser, V., Spector, T. D., & GIANT Consortium
Venue
PLoS Genetics
Publisher
Public Library of Science (PLoS)
Published
2009-12-11
Volume
5
Issue
12
Pages
e1000768
ISSN
  • 1553-7390 (ISSN-L)
  • 1553-7404
DOI
10.1371/journal.pgen.1000768
OpenAlex
W2137284096
Cited by
169
References
12
FWCI
8.73
Type
journal article
Language
en
Open access
gold

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels. https://app.cochat.ai/papers/10.1371/journal.pgen.1000768
The paper
Richards, J. B., Waterworth, D., O'Rahilly, S., Hivert, M.-F., Loos, R. J. F., Perry, J. R. B., Tanaka, T., Timpson, N. J., Semple, R. K., Soranzo, N., Song, K., Rocha, N., Grundberg, E., Dupuis, J., Florez, J. C., Langenberg, C., Prokopenko, I., Saxena, R., Sladek, R., . . . GIANT Consortium. (2009). A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1000768

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.