The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Aging and Chronic Sun Exposure Cause Distinct Epigenetic Changes in Human Skin
Open accessAbstract
Epigenetic changes are widely considered to play an important role in aging, but experimental evidence to support this hypothesis has been scarce. We have used array-based analysis to determine genome-scale DNA methylation patterns from human skin samples and to investigate the effects of aging, chronic sun exposure, and tissue variation. Our results reveal a high degree of tissue specificity in the methylation patterns and also showed very little interindividual variation within tissues. Data stratification by age revealed that DNA from older individuals was characterized by a specific hypermethylation pattern affecting less than 1% of the markers analyzed. Interestingly, stratification by sun exposure produced a fundamentally different pattern with a significant trend towards hypomethylation. Our results thus identify defined age-related DNA methylation changes and suggest that these alterations might contribute to the phenotypic changes associated with skin aging.
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Cites
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Cited by
DNA methylation age of human tissues and cell types
Horvath, S. (2013) · Genome Biology · doi:10.1186/gb-2013-14-10-r115 · Cited by 7,075
Epigenetics and the environment: emerging patterns and implications
Feil, R., & Fraga, M. F. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3142 · Cited by 1,929
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DNA methylation and healthy human aging
Jones, M. J., Goodman, S. J., & Kobor, M. S. (2015) · Aging Cell · doi:10.1111/acel.12349 · Cited by 928
Factors underlying variable DNA methylation in a human community cohort
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Metadata
- Authors
- Grönniger, E., Weber, B., Heil, O., Peters, N., Stäb, F., Wenck, H., Korn, B., Winnefeld, M., & Lyko, F.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-05-27
- Volume
- 6
- Issue
- 5
- Pages
- e1000971
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2073393965
- Cited by
- 263
- References
- 10
- FWCI
- 7.21
- Type
- journal article
- Language
- en
- Open access
- gold
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- Grönniger, E., Weber, B., Heil, O., Peters, N., Stäb, F., Wenck, H., Korn, B., Winnefeld, M., & Lyko, F. (2010). Aging and Chronic Sun Exposure Cause Distinct Epigenetic Changes in Human Skin. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1000971
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
