The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Common Variants in Left/Right Asymmetry Genes and Pathways Are Associated with Relative Hand Skill
Open accessAbstract
Humans display structural and functional asymmetries in brain organization, strikingly with respect to language and handedness. The molecular basis of these asymmetries is unknown. We report a genome-wide association study meta-analysis for a quantitative measure of relative hand skill in individuals with dyslexia [reading disability (RD)] (n = 728). The most strongly associated variant, rs7182874 (P = 8.68 × 10(-9)), is located in PCSK6, further supporting an association we previously reported. We also confirmed the specificity of this association in individuals with RD; the same locus was not associated with relative hand skill in a general population cohort (n = 2,666). As PCSK6 is known to regulate NODAL in the development of left/right (LR) asymmetry in mice, we developed a novel approach to GWAS pathway analysis, using gene-set enrichment to test for an over-representation of highly associated variants within the orthologs of genes whose disruption in mice yields LR asymmetry phenotypes. Four out of 15 LR asymmetry phenotypes showed an over-representation (FDR ≤ 5%). We replicated three of these phenotypes; situs inversus, heterotaxia, and double outlet right ventricle, in the general population cohort (FDR ≤ 5%). Our findings lead us to propose that handedness is a polygenic trait controlled in part by the molecular mechanisms that establish LR body asymmetry early in development.
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Howie, B. N., Donnelly, P., & Marchini, J. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000529 · Cited by 3,928
A linear complexity phasing method for thousands of genomes
Delaneau, O., Marchini, J., & Zagury, J.-F. (2012) · Nature Methods · doi:10.1038/nmeth.1785 · Cited by 1,850
Data quality control in genetic case-control association studies
Anderson, C. A., Pettersson, F. H., Clarke, G. M., Cardon, L. R., Morris, A. P., & Zondervan, K. T. (2010) · Nature Protocols · doi:10.1038/nprot.2010.116 · Cited by 1,318
Self-citationThe New Genomics: Global Views of Biology
Lander, E. S. (1996) · Science · doi:10.1126/science.274.5287.536 · Cited by 1,174
Haycraft, C. J., Banizs, B., Aydin-Son, Y., Zhang, Q., Michaud, E. J., & Yoder, B. K. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010053 · Cited by 902
Segrè, A. V., DIAGRAM Consortium, MAGIC investigators, Groop, L., Mootha, V. K., Daly, M. J., & Altshuler, D. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001058 · Cited by 463
Cited by
Human handedness: A meta-analysis.
Papadatou-Pastou, M., Ntolka, E., Schmitz, J., Martin, M., Munafò, M. R., Ocklenburg, S., & Paracchini, S. (2020) · Psychological Bulletin · doi:10.1037/bul0000229 · Cited by 526
Self-citationBrain Lateralization: A Comparative Perspective
Güntürkün, O., Ströckens, F., & Ocklenburg, S. (2020) · Physiological Reviews · doi:10.1152/physrev.00006.2019 · Cited by 484
Left Brain, Right Brain: Facts and Fantasies
Corballis, M. C. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001767 · Cited by 276
Neuronal control of locomotor handedness in Drosophila
Buchanan, S. M., Kain, J. S., & de Bivort, B. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500804112 · Cited by 179
Complex Trajectories of Brain Development in the Healthy Human Fetus
Andescavage, N. N., du Plessis, A., McCarter, R., Serag, A., Evangelou, I., Vezina, G., Robertson, R., & Limperopoulos, C. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw306 · Cited by 163
Metadata
- Authors
- Brandler, W. M., Morris, A. P., Evans, D. M., Scerri, T. S., Kemp, J. P., Timpson, N. J., St Pourcain, B., Smith, G. D., Ring, S. M., Stein, J., Monaco, A. P., Talcott, J. B., Fisher, S. E., Webber, C., & Paracchini, S.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-09-12
- Volume
- 9
- Issue
- 9
- Pages
- e1003751
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W2145827570
- Cited by
- 164
- References
- 6
- FWCI
- 8.08
- Type
- journal article
- Language
- en
- Open access
- gold
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- Brandler, W. M., Morris, A. P., Evans, D. M., Scerri, T. S., Kemp, J. P., Timpson, N. J., St Pourcain, B., Smith, G. D., Ring, S. M., Stein, J., Monaco, A. P., Talcott, J. B., Fisher, S. E., Webber, C., & Paracchini, S. (2013). Common Variants in Left/Right Asymmetry Genes and Pathways Are Associated with Relative Hand Skill. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1003751
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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