The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Genetic Recombination Is Targeted towards Gene Promoter Regions in Dogs
Open accessAbstract
The identification of the H3K4 trimethylase, PRDM9, as the gene responsible for recombination hotspot localization has provided considerable insight into the mechanisms by which recombination is initiated in mammals. However, uniquely amongst mammals, canids appear to lack a functional version of PRDM9 and may therefore provide a model for understanding recombination that occurs in the absence of PRDM9, and thus how PRDM9 functions to shape the recombination landscape. We have constructed a fine-scale genetic map from patterns of linkage disequilibrium assessed using high-throughput sequence data from 51 free-ranging dogs, Canis lupus familiaris. While broad-scale properties of recombination appear similar to other mammalian species, our fine-scale estimates indicate that canine highly elevated recombination rates are observed in the vicinity of CpG rich regions including gene promoter regions, but show little association with H3K4 trimethylation marks identified in spermatocytes. By comparison to genomic data from the Andean fox, Lycalopex culpaeus, we show that biased gene conversion is a plausible mechanism by which the high CpG content of the dog genome could have occurred.
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Cites
A second generation human haplotype map of over 3.1 million SNPs
The International HapMap Consortium (2007) · Nature · doi:10.1038/nature06258 · Cited by 4,438
Genome sequence, comparative analysis and haplotype structure of the domestic dog
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Drive Against Hotspot Motifs in Primates Implicates the PRDM9 Gene in Meiotic Recombination
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Prdm9 Controls Activation of Mammalian Recombination Hotspots
Parvanov, E. D., Petkov, P. M., & Paigen, K. (2010) · Science · doi:10.1126/science.1181495 · Cited by 610
A histone H3 methyltransferase controls epigenetic events required for meiotic prophase
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Genetic recombination is directed away from functional genomic elements in mice
Brick, K., Smagulova, F., Khil, P., Camerini-Otero, R. D., & Petukhova, G. V. (2012) · Nature · doi:10.1038/nature11089 · Cited by 414
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Cited by
Marsden, C. D., Ortega-Del Vecchyo, D., O’Brien, D. P., Taylor, J. F., Ramirez, O., Vilà, C., Marques-Bonet, T., Schnabel, R. D., Wayne, R. K., & Lohmueller, K. E. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1512501113 · Cited by 333
Out of southern East Asia: the natural history of domestic dogs across the world
Wang, G.-D., Zhai, W., Yang, H.-C., Wang, L., Zhong, L., Liu, Y.-H., Fan, R.-X., Yin, T.-T., Zhu, C.-L., Poyarkov, A. D., et al. (2016) · Cell Research · doi:10.1038/cr.2015.147 · Cited by 351
Stable recombination hotspots in birds
Singhal, S., Leffler, E. M., Sannareddy, K., Turner, I., Venn, O., Hooper, D. M., Strand, A. I., Li, Q., Raney, B., Balakrishnan, C. N., et al. (2015) · Science · doi:10.1126/science.aad0843 · Cited by 344
Coevolution between transposable elements and recombination
Kent, T. V., Uzunović, J., & Wright, S. I. (2017) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2016.0458 · Cited by 312
Skoglund, P., Ersmark, E., Palkopoulou, E., & Dalén, L. (2015) · Current Biology · doi:10.1016/j.cub.2015.04.019 · Cited by 310
Metadata
- Authors
- Auton, A., Rui Li, Y., Kidd, J., Oliveira, K., Nadel, J., Holloway, J. K., Hayward, J. J., Cohen, P. E., Greally, J. M., Wang, J., Bustamante, C. D., & Boyko, A. R.
- Venue
- PLoS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2013-12-12
- Volume
- 9
- Issue
- 12
- Pages
- e1003984
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- OpenAlex
- W1967686316
- Cited by
- 230
- References
- 8
- FWCI
- 18.33
- Type
- journal article
- Language
- en
- Open access
- gold
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- Auton, A., Rui Li, Y., Kidd, J., Oliveira, K., Nadel, J., Holloway, J. K., Hayward, J. J., Cohen, P. E., Greally, J. M., Wang, J., Bustamante, C. D., & Boyko, A. R. (2013). Genetic Recombination Is Targeted towards Gene Promoter Regions in Dogs. PLoS Genetics. https://doi.org/10.1371/journal.pgen.1003984
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