The Rheb GTPase promotes pheromone blindness via a TORC1-independent pathway in the phytopathogenic fungus Ustilago maydis
Open accessAbstract
The target of the rapamycin (TOR) signaling pathway plays a negative role in controlling virulence in phytopathogenic fungi. However, the actual targets involved in virulence are currently unknown. Using the corn smut fungus Ustilago maydis , we tried to address the effects of the ectopic activation of TOR on virulence. We obtained gain-of-function mutations in the Rheb GTPase, one of the conserved TOR kinase regulators. We have found that unscheduled activation of Rheb resulted in the alteration of the proper localization of the pheromone receptor, Pra1, and thereby pheromone insensitivity. Since pheromone signaling triggers virulence in Ustilaginales, we believe that the Rheb-induced pheromone blindness was responsible for the associated lack of virulence. Strikingly, although these effects required the concourse of the Rsp5 ubiquitin ligase and the Art3 α-arrestin, the TOR kinase was not involved. Several eukaryotic organisms have shown that Rheb transmits environmental information through TOR-dependent and -independent pathways. Therefore, our results expand the range of signaling manners at which environmental conditions could impinge on the virulence of phytopathogenic fungi.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Initial efforts to enhance conformational sampling have involved altering the number of sequences used to generate shallower MSA representations, masking coevolutionary information from MSAs, and splitting conflicting coevolutionary signals by clustering MSAs.
“Initial efforts to enhance sampling of different conformations have involved altering the number of sequences used to generate shallower MSA representations, masking coevolutionary information provided by MSAs, and splitting conflicting coevolutionary signals by clustering MSAs46,47,105.”
From The power and pitfalls of AlphaFold2 for structure prediction beyond rigid globular proteins (2024) · cites this paper as [105]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
mTOR Signaling in Growth, Metabolism, and Disease
Saxton, R. A., & Sabatini, D. M. (2017) · Cell · doi:10.1016/j.cell.2017.02.004 · Cited by 7,555 · see citing works
mTOR Signaling in Growth, Metabolism, and Disease.
Saxton, R., & Sabatini, D. (2017) · Cell · doi:10.1016/j.cell.2017.03.035 · Cited by 3,889 · see citing works
Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast
Heitman, J., Movva, N. R., & Hall, M. N. (1991) · Science · doi:10.1126/science.1715094 · Cited by 2,010 · see citing works
Thoreen, C. C., Kang, S. A., Chang, J. W., Liu, Q., Zhang, J., Gao, Y., Reichling, L. J., Sim, T., Sabatini, D. M., & Gray, N. S. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m900301200 · Cited by 1,803 · see citing works
Tee, A. R., Manning, B. D., Roux, P. P., Cantley, L. C., & Blenis, J. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00506-2 · Cited by 1,211 · see citing works
Insights from the genome of the biotrophic fungal plant pathogen Ustilago maydis
Kämper, J., Kahmann, R., Bölker, M., Ma, L., Brefort, T., Saville, B. J., Banuett, F., Kronstad, J. W., Gold, S. E., Müller, O., et al. (2006) · Nature · doi:10.1038/nature05248 · Cited by 1,209 · see citing works
Self-citationmTOR as a central hub of nutrient signalling and cell growth
Kim, J., & Guan, K. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0205-1 · Cited by 1,067 · see citing works
Sch9 Is a Major Target of TORC1 in Saccharomyces cerevisiae
Urban, J., Soulard, A., Huber, A., Lippman, S., Mukhopadhyay, D., Deloche, O., Wanke, V., Anrather, D., Ammerer, G., Riezman, H., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.04.020 · Cited by 798 · see citing works
Nutrient sensing and TOR signaling in yeast and mammals
González, A., & Hall, M. N. (2017) · The EMBO Journal · doi:10.15252/embj.201696010 · Cited by 725 · see citing works
TOR Signaling and Nutrient Sensing
Dobrenel, T., Caldana, C., Hanson, J., Robaglia, C., Vincentz, M., Veit, B. E., & Meyer, C. (2016) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-043014-114648 · Cited by 449 · see citing works
Rapamycin and mTOR kinase inhibitors
Ballou, L. M., & Lin, R. Z. (2008) · Journal of Chemical Biology · doi:10.1007/s12154-008-0003-5 · Cited by 444 · see citing works
Banuett, F., & Herskowitz, I. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.15.5878 · Cited by 398 · see citing works
The a mating type locus of U. maydis specifies cell signaling components
Bölker, M., Urban, M., & Kahmann, R. (1992) · Cell · doi:10.1016/0092-8674(92)90182-c · Cited by 373 · see citing works
Brefort, T., Doehlemann, G., Mendoza‐Mendoza, A., et al. (2009) · Annual Review of Phytopathology · doi:10.1146/annurev-phyto-080508-081923 · Cited by 351 · see citing works
Shintani, T., & Klionsky, D. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404399200 · Cited by 345 · see citing works
Identification of genes in the bW/bE regulatory cascade in Ustilago maydis
Brachmann, A., Weinzierl, G., Kämper, J., & Kahmann, R. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02699.x · Cited by 292 · see citing works
Isolation and Characterization of an Autonomously Replicating Sequence from Ustilago maydis
Tsukuda, T., Carleton, S., Fotheringham, S., & Holloman, W. K. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.9.3703 · Cited by 289 · see citing works
López‐Berges, M. S., Rispail, N., Prados‐Rosales, R., et al. (2010) · The Plant Cell · doi:10.1105/tpc.110.075937 · Cited by 258 · see citing works
Koltin, Y., Faucette, L. F., Bergsma, D. J., Levy, M. A., Cafferkey, R., Koser, P. L., Johnson, R. K., & Livi, G. P. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.3.1718-1723.1991 · Cited by 249 · see citing works
The ubiquitin code of yeast permease trafficking
Lauwers, E., Erpapazoglou, Z., Haguenauer‐Tsapis, R., & André, B. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.01.004 · Cited by 245 · see citing works
THE MOLECULAR GENETICS OF NITRATE ASSIMILATION IN FUNGI AND PLANTS
Crawford, N. M., & Arst, H. N. (1993) · Annual Review of Genetics · doi:10.1146/annurev.ge.27.120193.000555 · Cited by 243 · see citing works
TOR signaling in plants: conservation and innovation
Shi, L., Wu, Y., & Sheen, J. (2018) · Development · doi:10.1242/dev.160887 · Cited by 228 · see citing works
The TOR signalling network from yeast to man
VIRGILIO, C. D., & Loewith, R. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.02.013 · Cited by 227 · see citing works
The pheromone response factor coordinates filamentous growth and pathogenicity in Ustilago maydis.
Hartmann, H., Kahmann, R., & Bölker, M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00508.x · Cited by 226 · see citing works
Genome editing in Ustilago maydis using the CRISPR–Cas system
Schuster, M., Schweizer, G., Reißmann, S., & Kahmann, R. (2015) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2015.09.001 · Cited by 223 · see citing works
Tor2 Directly Phosphorylates the AGC Kinase Ypk2 To Regulate Actin Polarization
Kamada, Y., Fujioka, Y., Suzuki, N. N., Inagaki, F., Wullschleger, S., Loewith, R., Hall, M. N., & Ohsumi, Y. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.7239-7248.2005 · Cited by 207 · see citing works
TORC1 Regulates Endocytosis via Npr1-Mediated Phosphoinhibition of a Ubiquitin Ligase Adaptor
MacGurn, J. A., Hsu, P.-C., Smolka, M. B., & Emr, S. D. (2011) · Cell · doi:10.1016/j.cell.2011.09.054 · Cited by 203 · see citing works
TOR regulation of AGC kinases in yeast and mammals
Jacinto, E., & Lorberg, A. (2008) · Biochemical Journal · doi:10.1042/bj20071518 · Cited by 201 · see citing works
Diverse nitrogen signals activate convergent ROP2-TOR signaling in Arabidopsis
Liu, Y., Duan, X., Zhao, X., Ding, W., Wang, Y., & Xiong, Y. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.03.022 · Cited by 166 · see citing works
The TOR signaling pathway regulates vegetative development and virulence inFusarium graminearum
Yu, F., Gu, Q., Yun, Y., et al. (2014) · New Phytologist · doi:10.1111/nph.12776 · Cited by 165 · see citing works
Crespo, J. L., Díaz‐Troya, S., & Florencio, F. J. (2005) · PLANT PHYSIOLOGY · doi:10.1104/pp.105.070847 · Cited by 161 · see citing works
Regulation of Autophagy through TORC1 and mTORC1
Noda, T. (2017) · Biomolecules · doi:10.3390/biom7030052 · Cited by 145 · see citing works
Fungal development of the plant pathogenUstilago maydis
Vollmeister, E., Schipper, K., Baumann, S. J., et al. (2011) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00296.x · Cited by 144 · see citing works
Broomfield, P. L. E., & Hargreaves, J. A. (1992) · Current Genetics · doi:10.1007/bf00351470 · Cited by 143 · see citing works
Müller, P., Weinzierl, G., Brachmann, A., et al. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.6.1187-1199.2003 · Cited by 135 · see citing works
Niles, B. J., Mogri, H., Hill, A., Vlahakis, A., & Powers, T. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117563109 · Cited by 134 · see citing works
Endocytosis Is Essential for Pathogenic Development in the Corn Smut Fungus Ustilago maydis
Fuchs, U., Hause, G., Schuchardt, I., et al. (2006) · The Plant Cell · doi:10.1105/tpc.105.039388 · Cited by 131 · see citing works
Hartmann, H., Krüger, J., Lottspeich, F., et al. (1999) · The Plant Cell · doi:10.1105/tpc.11.7.1293 · Cited by 127 · see citing works
A homologue of the transcriptional repressor Ssn6p antagonizes cAMP signalling in Ustilago maydis
Loubradou, G., Brachmann, A., Feldbrügge, M., et al. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02424.x · Cited by 123 · see citing works
Marroquin‐Guzman, M., & Wilson, R. A. (2015) · PLoS Pathogens · doi:10.1371/journal.ppat.1004851 · Cited by 121 · see citing works
Genetic regulation of mating and dimorphism in Ustilago maydis
Bölker, M., Genin, S., Lehmler, C., & Kahmann, R. (1995) · Canadian Journal of Botany · doi:10.1139/b95-262 · Cited by 115 · see citing works
PKA and MAPK phosphorylation of Prf1 allows promoter discrimination in Ustilago maydis
Kaffarnik, F. A. R., Müller, P., Leibundgut, M., Kahmann, R., & Feldbrügge, M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg554 · Cited by 115 · see citing works
Pub1 acts as an E6‐AP‐like protein ubiquitiin ligase in the degradation of cdc25.
NEFSKY, B., & Beach, D. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00472.x · Cited by 110 · see citing works
Establishing a versatile Golden Gate cloning system for genetic engineering in fungi
Terfrüchte, M., Joehnk, B., Fajardo-Somera, R. A., et al. (2013) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2013.10.012 · Cited by 110 · see citing works
Tsc1+ and tsc2+ Regulate Arginine Uptake and Metabolism in Schizosaccharomyces pombe
van Slegtenhorst, M., Carr, E. L., Stoyanova, R. S., Kruger, W. D., & Henske, E. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313874200 · Cited by 106 · see citing works
Matsumoto, S., Bandyopadhyay, A., Kwiatkowski, D. J., Maitra, U., & Matsumoto, T. (2002) · Genetics · doi:10.1093/genetics/161.3.1053 · Cited by 106 · see citing works
Substrate-Induced Ubiquitylation and Endocytosis of Yeast Amino Acid Permeases
Ghaddar, K., Merhi, A., Saliba, E., et al. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00699-14 · Cited by 103 · see citing works
Regulation of TOR by small GTPases
Durán, R. V., & Hall, M. N. (2012) · The EMBO Reports · doi:10.1038/embor.2011.257 · Cited by 102 · cited 1× · see citing works
“Rheb conveys signals from environmental cues in metazoan, including growth factors, energy, and oxygen levels [21].”
BackgroundIsolation and Characterization of an Autonomously Replicating Sequence from Ustilago maydis
Tsukuda, T., Carleton, S., Fotheringham, S., et al. (1988) · Molecular and Cellular Biology · doi:10.1128/mcb.8.9.3703-3709.1988 · Cited by 101 · see citing works
Nakashima, A., Sato, T., & Tamanoi, F. (2010) · Journal of Cell Science · doi:10.1242/jcs.060319 · Cited by 98 · see citing works
Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis
Carroll, B., Korolchuk, V. I., & Sarkar, S. (2014) · Amino Acids · doi:10.1007/s00726-014-1775-2 · Cited by 95 · see citing works
Urano, J., Comiso, M. J., Guo, L., Aspuria, P.-J. P., Deniskin, R., Tabancay, A. P., Kato‐Stankiewicz, J., & Tamanoi, F. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04877.x · Cited by 94 · see citing works
Mayer, L. M., Baars, T. L., & Mayer, A. (2012) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-08-0703 · Cited by 94 · see citing works
Alvaro, C. G., O’Donnell, A. F., Prosser, D. C., Augustine, A. A., Goldman, A. R., Brodsky, J. L., Cyert, M., Wendland, B., & Thorner, J. W. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00230-14 · Cited by 87 · see citing works
Non‐canonical functions of the tuberous sclerosis complex‐Rheb signalling axis
Neuman, N. A., & Henske, E. P. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100131 · Cited by 84 · see citing works
Nakashima, A., Otsubo, Y., Yamashita, A., et al. (2012) · Journal of Cell Science · doi:10.1242/jcs.111146 · Cited by 83 · see citing works
Schüler, D., Wahl, R., Wippel, K., et al. (2015) · New Phytologist · doi:10.1111/nph.13314 · Cited by 82 · see citing works
Khrunyk, Y. Y., Münch, K., Schipper, K., et al. (2010) · New Phytologist · doi:10.1111/j.1469-8137.2010.03413.x · Cited by 82 · see citing works
Marroquin‐Guzman, M., Sun, G., & Wilson, R. A. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006557 · Cited by 76 · see citing works
Boeckstaens, M., Llinares, E., van Vooren, P., & Marini, A. (2014) · Nature Communications · doi:10.1038/ncomms4101 · Cited by 75 · see citing works
The Architecture of the Rag GTPase Signaling Network
Nicastro, R., Sardu, A., Panchaud, N., & VIRGILIO, C. D. (2017) · Biomolecules · doi:10.3390/biom7030048 · Cited by 73 · see citing works
Panepinto, J. C., Oliver, B. G., Fortwendel, J. R., Smith, D. L. H., Askew, D. S., & Rhodes, J. C. (2003) · Infection and Immunity · doi:10.1128/iai.71.5.2819-2826.2003 · Cited by 72 · see citing works
Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom
Shertz, C. A., Bastidas, R. J., Li, W., Heitman, J., & Cardenas, M. E. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-510 · Cited by 71 · see citing works
TORC1-Dependent Phosphorylation Targets in Fission Yeast
Otsubo, Y., Nakashima, A., Yamamoto, M. P., & Yamashita, A. (2017) · Biomolecules · doi:10.3390/biom7030050 · Cited by 68 · see citing works
Tsao, C.-C., Chen, Y.-T., & Lan, C. (2008) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2008.11.008 · Cited by 56 · see citing works
Evolution of the TSC1/TSC2-TOR Signaling Pathway
Serfontein, J., Nisbet, R. E. R., Howe, C. J., & de Vries, P. J. (2010) · Science Signaling · doi:10.1126/scisignal.2000803 · Cited by 52 · see citing works
Zarnack, K., Eichhorn, H., Kahmann, R., et al. (2008) · Molecular Microbiology · doi:10.1111/j.1365-2958.2008.06345.x · Cited by 48 · see citing works
The α‐arrestin family of ubiquitin ligase adaptors links metabolism with selective endocytosis
Kahlhofer, J., Sébastien Léon, A., Teis, D., & Schmidt, O. (2020) · Biology of the Cell · doi:10.1111/boc.202000137 · Cited by 46 · see citing works
Stephan, J. S., Yeh, Y.-Y., Ramachandran, V., Deminoff, S. J., & Herman, P. K. (2010) · Autophagy · doi:10.4161/auto.6.2.11129 · Cited by 45 · see citing works
Yang, W., Pang, D., Chen, M., Du, C., Jia, L., Wang, L., He, Y., Jiang, W., Luo, L., Yu, Z., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2021.02.022 · Cited by 45 · see citing works
Expression of the Aspergillus fumigatus rheb homologue, rhbA, is induced by nitrogen starvation
Panepinto, J. C., Oliver, B. G. G., Amlung, T. W., Askew, D. S., & Rhodes, J. C. (2002) · Fungal Genetics and Biology · doi:10.1016/s1087-1845(02)00022-1 · Cited by 44 · see citing works
TORC2 and the AGC kinase Gad8 regulate phosphorylation of the ribosomal protein S6 in fission yeast
Du, W., Hálová, L., Kirkham, S., Atkin, J., & Petersen, J. (2012) · Biology Open · doi:10.1242/bio.20122022 · Cited by 41 · see citing works
Membrane trafficking of yeast transporters: mechanisms and physiological control of downregulation
Haguenauer‐Tsapis, R., & André, B. (2004) · Topics in current genetics · doi:10.1007/b97215 · Cited by 39 · see citing works
Prosser, D. C., Pannunzio, A., Brodsky, J., Thorner, J., Wendland, B., & O’Donnell, A. F. (2015) · Journal of Cell Science · doi:10.1242/jcs.175372 · Cited by 36 · see citing works
Chia, K., Fukuda, T., Sofyantoro, F., Matsuda, T., Amai, T., & Shiozaki, K. (2017) · eLife · doi:10.7554/elife.30880 · Cited by 36 · see citing works
Michels, A. A. (2011) · Biochemical Society Transactions · doi:10.1042/bst0390487 · Cited by 35 · see citing works
Sun, G., Qi, X., & Wilson, R. A. (2018) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-10-18-0287-r · Cited by 35 · see citing works
Boeckstaens, M., Merhi, A., Llinares, E., Vooren, P. V., Springael, J., Wintjens, R. T., & Marini, A. M. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005382 · Cited by 33 · see citing works
Nakase, Y., Nakase, M., Kashiwazaki, J., Murai, T., Otsubo, Y., Mabuchi, I., Yamamoto, M. P., Takegawa, K., & Matsumoto, T. (2013) · Journal of Cell Science · doi:10.1242/jcs.128355 · Cited by 33 · see citing works
Nakashima, A., Kamada, S., Tamanoi, F., & Kikkawa, U. (2014) · Biology Open · doi:10.1242/bio.20148367 · Cited by 33 · see citing works
Mielnichuk, N., Sgarlata, C., & Pérez‐Martín, J. (2009) · Journal of Cell Science · doi:10.1242/jcs.052233 · Cited by 33 · see citing works
Self-citationShi, H., Meng, S., Qiu, J., et al. (2021) · Molecular Plant Pathology · doi:10.1111/mpp.13074 · Cited by 33 · see citing works
Cell cycle-dependent regulation of plant infection by the rice blast fungus Magnaporthe oryzae
Osés-Ruiz, M., & Talbot, N. J. (2017) · Communicative & Integrative Biology · doi:10.1080/19420889.2017.1372067 · Cited by 32 · see citing works
Nakase, M., Nakase, Y., Chardwiriyapreecha, S., et al. (2011) · Microbiology · doi:10.1099/mic.0.053389-0 · Cited by 31 · see citing works
Murai, T., Nakase, Y., Fukuda, K., Chikashige, Y., Tsutsumi, C., Hiraoka, Y., & Matsumoto, T. (2009) · Genetics · doi:10.1534/genetics.109.105379 · Cited by 31 · see citing works
A genome-based analysis of amino acid metabolism in the biotrophic plant pathogen Ustilago maydis
McCann, M. P., & Snetselaar, K. M. (2008) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2008.05.006 · Cited by 30 · see citing works
Programmed cell cycle arrest is required for infection of corn plants by the fungus Ustilago maydis
Castanheira, S. M., Mielnichuk, N., & Pérez‐Martín, J. (2014) · Development · doi:10.1242/dev.113415 · Cited by 30 · see citing works
Self-citationFukuda, T., Sofyantoro, F., Tai, Y.-S., Chia, K., Matsuda, T., Murase, T., Morozumi, Y., Tatebe, H., Kanki, T., & Shiozaki, K. (2021) · eLife · doi:10.7554/elife.60969 · Cited by 28 · see citing works
de Sena-Tomás, C., Fernández-Álvarez, A., Holloman, W. K., & Pérez‐Martín, J. (2011) · The Plant Cell · doi:10.1105/tpc.110.082552 · Cited by 24 · see citing works
Self-citationHarata, K., Nishiuchi, T., & Kubo, Y. (2016) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-02-16-0030-r · Cited by 24 · see citing works
Versatile CRISPR/Cas9 Systems for Genome Editing in Ustilago maydis
Wege, S.-M., Gejer, K., Becker, F., Bölker, M., Freitag, J., & Sandrock, B. (2021) · Journal of Fungi · doi:10.3390/jof7020149 · Cited by 19 · see citing works
Berndt, P., Lanver, D., & Kahmann, R. (2010) · Molecular Microbiology · doi:10.1111/j.1365-2958.2010.07422.x · Cited by 18 · see citing works
Segreto, R., Bazafkan, H., Millinger, J., Schenk, M., Atanasova, L., Doppler, M., Bueschl, C., Boeckstaens, M., Diaz, S. S., Schreiner, U., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0262180 · Cited by 18 · see citing works
The Rag GTPase-Ragulator complex attenuates TOR complex 1 signaling in fission yeast
Fukuda, T., & Shiozaki, K. (2018) · Autophagy · doi:10.1080/15548627.2018.1444313 · Cited by 16 · see citing works
Liu, Q., Ma, Y., Zhou, X., & Furuyashiki, T. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139045 · Cited by 15 · see citing works
Dong, B., Xu, X., Chen, G., et al. (2016) · Scientific Reports · doi:10.1038/srep30963 · Cited by 12 · see citing works
Role for nitrate assimilatory genes in virulence of Ustilago maydis
Khanal, S., Schroeder, L. A., Nava-Mercado, O. A., et al. (2021) · Fungal Biology · doi:10.1016/j.funbio.2021.04.010 · Cited by 9 · see citing works
Bardetti, P., Castanheira, S. M., Valerius, O., et al. (2019) · eLife · doi:10.7554/elife.48943 · Cited by 7 · see citing works
Alao, J. P., & Sunnerhagen, P. (2020) · Cell Division · doi:10.1186/s13008-020-00066-1 · Cited by 7 · see citing works
Nishino, K., Kushima, M., Matsuo, Y., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141796 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [93]Holliday R. Ustilago maydis. In: King RC, editor. Handbook of Genetics. New York: Plenum Press; 1974. p. 575– 95.
Cited by
Sorted by citations
The power and pitfalls of AlphaFold2 for structure prediction beyond rigid globular proteins
Agarwal, V., & McShan, A. C. (2024) · Nature Chemical Biology · doi:10.1038/s41589-024-01638-w · Cited by 155 · see citing works
- Authors
- de la Torre, A., & Pérez-Martín, J.
- ORCID
- Pérez-Martín, José
- Venue
- PLOS Genetics
- Publisher
- Public Library of Science (PLoS)
- Published
- 2022-11-14
- Volume
- 18
- Issue
- 11
- Pages
- e1010483
- ISSN
- 1553-7390 (ISSN-L)
- 1553-7404
- PMC
- PMC9704768
- OpenAlex
- W4308951991
- Cited by
- 5
- References
- 100
- Citations by year
- 2026: 3 · 2024: 2
- FWCI
- 0.16
- Type
- journal article
- Language
- en
- Update notices
- new_version (2022-11-28)
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS Genetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministerio de Ciencia e Innovación (PID2020-120242GB-I00)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Plant Pathogens and Fungal Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- TOR signaling, pheromone signaling, fungal virulence, Ustilago maydis, Rsp5 ubiquitin ligase, plant pathogenic fungi, corn smut, gain-of-function mutations
- MeSH terms
- Ras Homolog Enriched in Brain Protein, Mechanistic Target of Rapamycin Complex 1, Basidiomycota, Blindness, Zea mays, Fungal Proteins, Fungi, Pheromones, Ustilago
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
