The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Observational Research, Randomised Trials, and Two Views of Medical Science
Open accessAbstract
Two views exist of medical science, says the author, one emphasizing discovery and explanation, the other emphasizing evaluation of interventions.
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“Because the strengths and limitations of methods used to conduct research with routinely collected data may be contentious, a clear description of a study’s objectives is essential [23,24].”
From The Reporting of Studies Conducted Using Observational Routinely-Collected Health Data (RECORD) statement. (2015) · cites this paper as [23]
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Cites
von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., Vandenbroucke, J. P., & Initiative, F. T. S. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040296 · Cited by 23,020
Self-citationGenome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
The Wellcome Trust Case Control Consortium, Management Committee, Burton, P. R., Clayton, D. G., Cardon, L. R., Craddock, N., Deloukas, P., Duncanson, A., Kwiatkowski, D. P., McCarthy, M. I., et al. (2007) · Nature · doi:10.1038/nature05911 · Cited by 9,442
From the New York Times Magazine
Minsky, & Hyman, P. (1979) · Cited by 6,899
No adjustments are needed for multiple comparisons.
Rothman, K. J. (1990) · Epidemiology · doi:10.1097/00001648-199001000-00010 · Cited by 5,965
Why Most Published Research Findings Are False
Ioannidis, J. P. A. (2005) · CHANCE · doi:10.1080/09332480.2005.10722754 · Cited by 4,702 · cited 1×
“The importance of the prior odds at which research is started was highlighted in a paper describing “Why most research findings are false” [45].”
BackgroundClinical Epidemiology: A Basic Science for Clinical Medicine.
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-114-9-825_9 · Cited by 3,497
The Wellcome Trust Case Control Consortium, U.K.
Mossman, K. (2008) · Scientific American · doi:10.1038/scientificamerican0108-42a · Cited by 2,714
Smoking and Carcinoma of the Lung
Doll, R., & Hill, A. B. (1950) · BMJ · doi:10.1136/bmj.2.4682.739 · Cited by 1,999
RE: “ESTIMABILITY AND ESTIMATION IN CASE-REFERENT STUDIES”
Halperin, M. (1977) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112409 · Cited by 1,546
Statistical Methods and Scientific Inference.
Bartlett, M. S., & Fisher, R. A. (1957) · Biometrika · doi:10.2307/2333276 · Cited by 1,294
Research works printed but not linked: 27
- Laine, 2007, N Engl J Med, 356, 2734
- Vandenbroucke, 1994, Lancet, 344, 1453
- Vandenbroucke, 2001, N Engl J Med, 344, 1527
- Vandenbroucke, 2005, N Engl J Med, 353, 1297
- Glasziou, 2007, BMJ, 334, 349
- Vandenbroucke, 2001, Ann Intern Med, 134, 330
- Vandenbroucke, 2004, Lancet, 363, 1728
- Schulz, 2002, Lancet, 359, 614
- Miettinen, 1983, Stat Med, 2, 267
- Vandenbroucke, 2006, CMAJ, 174, 645
- Papanikolaou, 2006, CMAJ, 174, 635
- Jick, 1978, Am J Epidemiol, 107, 1
- Djulbegovic, 2000, Lancet, 356, 635
- Kumar, 2005, BMJ, 331, 1295
- Rothman, 1990, Epidemiology, 1, 43
- Greenland, 2007, Int J Epidemiol, 36, 944
- Lipton, 2005, Science, 307, 219
- Brush, 2005, Science, 308, 1409
- Rothwell, 2005, Lancet, 365, 176
- Joost, 2002, Am J Respir Crit Care Med, 165, 795
- Goodman, 1998, Am J Epidemiol, 147, 807
- Moonesinghe, 2007, PLoS Med, 4, e28
- Khoury, 2007, Int J Epidemiol, 36, 439
- Maclure, 1993, Epidemiol Rev, 15, 328
- Mayes, 1988, Int J Epidemiol, 17, 680
- Schulz, 2002, Lancet, 359, 431
- Gould, 2000, Science, 287, 253
Cited by
Sorted by citations
Benchimol, E. I., Smeeth, L., Guttmann, A., Harron, K., Moher, D., Petersen, I., Sørensen, H. T., von Elm, E., Langan, S. M., & RECORD Working Committee (2015) · PLOS Medicine · doi:10.1371/journal.pmed.1001885 · Cited by 5,749
Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses
Vandenberg, L. N., Colborn, T., Hayes, T. B., Heindel, J. J., Jacobs, D. R., Lee, D.-H., Shioda, T., Soto, A. M., vom Saal, F. S., Welshons, W. V., et al. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1050 · Cited by 3,209
Interpretation of the evidence for the efficacy and safety of statin therapy
Collins, R., Reith, C., Emberson, J., Armitage, J., Baigent, C., Blackwell, L., Blumenthal, R., Danesh, J., Smith, G. D., DeMets, D., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31357-5 · Cited by 1,857
Why Most Discovered True Associations Are Inflated
Ioannidis, J. P. A. (2008) · Epidemiology · doi:10.1097/ede.0b013e31818131e7 · Cited by 1,495
Caspi, A., Hariri, A. R., Holmes, A., Uher, R., & Moffitt, T. E. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.09101452 · Cited by 1,346
Metadata
- Authors
- Vandenbroucke, J. P.
- Affiliations
- Royal Netherlands Academy of Arts and Sciences (NL)
- Corresponding author
- Vandenbroucke, Jan P
- ORCID
- Vandenbroucke, Jan P
- Venue
- PLoS Medicine
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-03-11
- Volume
- 5
- Issue
- 3
- Pages
- e67
- ISSN
- 1549-1277 (ISSN-L)
- 1549-1676
- PMC
- PMC2265762
- OpenAlex
- W2090226269
- Cited by
- 416
- References
- 66
- Citations by year
- 2026: 15 · 2025: 5 · 2024: 15 · 2023: 32 · 2022: 22 · 2021: 23 · 2020: 23 · 2019: 25 · 2018: 14 · 2017: 14 · 2016: 17 · 2015: 26 · 2014: 20 · 2013: 36 · 2012: 31
- FWCI
- 30.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Figshare (submittedVersion, cc-by)
- Funders
- London School of Hygiene and Tropical Medicine
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Advanced Causal Inference Techniques
- Social Sciences › Arts and Humanities › History and Philosophy of Science › Philosophy of Biology and Scientific Explanation
- Health Sciences › Nursing › Research and Theory › Methodologies in Health Research and Practice
- Keywords
- observational studies, randomised trials, medical sciences, intervention evaluation, philosophy of medicine
- MeSH terms
- Contraceptives, Oral, Evaluation Studies as Topic, Factor V, Female, Follow-Up Studies, Humans, Prospective Studies, Retrospective Studies, Case-Control Studies, Randomized Controlled Trials as Topic, Biomedical Research, Venous Thromboembolism
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