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Integrative Genomic Analyses Identify BRF2 as a Novel Lineage-Specific Oncogene in Lung Squamous Cell Carcinoma

Lockwood, William W., Chari, Raj, Coe, Bradley P., Thu, Kelsie L., Garnis, Cathie, Malloff, Chad A., Campbell, Jennifer, Williams, Ariane C., Hwang, Dorothy, Zhu, Chang-Qi, Buys, Timon P. H., Yee, John, English, John C., MacAulay, Calum, Tsao, Ming-Sound, Gazdar, Adi F., Minna, John D., Lam, Stephen, Lam, Wan L.·2010·PLoS Medicine
DOI 10.1371/journal.pmed.1000315PMC PMC2910599
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  • In an independent TCGA cohort of 230 LACs (33 EGFRMUT and 197 EGFRWT), all six chromosome 16 genes showed higher expression in EGFRMUT tumors, but only GGA2 met the significance threshold (Bonferroni-corrected P<0.001).

    “In order to identify the potential target gene of this alteration, we next compared the expression of all six genes in an independent cohort of 230 LACs from The Cancer Genome Atlas (TCGA)20 consisting of 33 EGFRMUT and 197 EGFRWT tumors. While all genes showed higher expression in EGFRMUT tumors, matching the results from the original datasets, only one gene, GGA2, met our significance threshold”

    From Integrative Genomic Analyses Identifies GGA2 as a Cooperative Driver of EGFR-Mediated Lung Tumorigenesis (2019) · cites this paper as [20]

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Metadata

Authors
Lockwood, W. W., Chari, R., Coe, B. P., Thu, K. L., Garnis, C., Malloff, C. A., Campbell, J., Williams, A. C., Hwang, D., Zhu, C.-Q., Buys, T. P. H., Yee, J., English, J. C., MacAulay, C., Tsao, M.-S., Gazdar, A. F., Minna, J. D., Lam, S., & Lam, W. L.
Venue
PLoS Medicine
Publisher
Public Library of Science (PLoS)
Published
2010-07-27
Volume
7
Issue
7
Pages
e1000315
ISSN
1549-1676
DOI
10.1371/journal.pmed.1000315
PMC
PMC2910599
Cited by
89
References
3
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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