The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Effect of Pneumococcal Conjugate Vaccination on Serotype-Specific Carriage and Invasive Disease in England: A Cross-Sectional Study
Open accessAbstract
BACKGROUND: We investigated the effect of the 7-valent pneumococcal conjugate vaccine (PCV7) programme in England on serotype-specific carriage and invasive disease to help understand its role in serotype replacement and predict the impact of higher valency vaccines. METHODS AND FINDINGS: Nasopharyngeal swabs were taken from children <5 y old and family members (n=400) 2 y after introduction of PCV7 into routine immunization programs. Proportions carrying Streptococcus pneumoniae and serotype distribution among carried isolates were compared with a similar population prior to PCV7 introduction. Serotype-specific case carrier ratios (CCRs) were estimated using national data on invasive disease. In vaccinated children and their contacts vaccine-type (VT) carriage decreased, but was offset by an increase in non-VT carriage, with no significant overall change in carriage prevalence, odds ratio 1.06 (95% confidence interval 0.76-1.49). The lower CCRs of the replacing serotypes resulted in a net reduction in invasive disease in children. The additional serotypes covered by higher valency vaccines had low carriage but high disease prevalence. Serotype 11C emerged as predominant in carriage but caused no invasive disease whereas 8, 12F, and 22F emerged in disease but had very low carriage prevalence. CONCLUSION: Because the additional serotypes included in PCV10/13 have high CCRs but low carriage prevalence, vaccinating against them is likely to significantly reduce invasive disease with less risk of serotype replacement. However, a few serotypes with high CCRs could mitigate the benefits of higher valency vaccines. Assessment of the effect of PCV on carriage as well as invasive disease should be part of enhanced surveillance activities for PCVs. Please see later in the article for the Editors' Summary.
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Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children
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Sustained Reductions in Invasive Pneumococcal Disease in the Era of Conjugate Vaccine
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Self-citationBrueggemann, A. B., Griffiths, D. T., Meats, E., Peto, T., Crook, D. W., & Spratt, B. G. (2003) · The Journal of Infectious Diseases · doi:10.1086/374624 · Cited by 619
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Association of Serotype with Risk of Death Due to Pneumococcal Pneumonia: A Meta‐Analysis
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Pneumococcal Capsular Polysaccharide Structure Predicts Serotype Prevalence
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Cited by
Waight, P. A., Andrews, N. J., Ladhani, S. N., Sheppard, C. L., Slack, M. P. E., & Miller, E. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)70044-7 · Cited by 589
Self-citationLadhani, S. N., Collins, S., Djennad, A., Sheppard, C. L., Borrow, R., Fry, N. K., Andrews, N. J., Miller, E., & Ramsay, M. E. (2018) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(18)30052-5 · Cited by 559
Self-citationFeikin, D. R., Kagucia, E. W., Loo, J. D., Link-Gelles, R., Puhan, M. A., Cherian, T., Levine, O. S., Whitney, C. G., O’Brien, K. L., Moore, M. R., et al. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001517 · Cited by 470
Effect of vaccines on bacterial meningitis worldwide
McIntyre, P. B., O'Brien, K. L., Greenwood, B., & van de Beek, D. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61187-8 · Cited by 326
Weinberger, D. M., Simonsen, L., Jordan, R., Steiner, C., Miller, M., & Viboud, C. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir749 · Cited by 132
Metadata
- Authors
- Flasche, S., Van Hoek, A. J., Sheasby, E., Waight, P., Andrews, N., Sheppard, C., George, R., & Miller, E.
- Venue
- PLoS Medicine
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-04-05
- Volume
- 8
- Issue
- 4
- Pages
- e1001017
- ISSN
- 1549-1277 (ISSN-L)
- 1549-1676
- OpenAlex
- W2053889461
- Cited by
- 277
- References
- 30
- FWCI
- 20.32
- Type
- journal article
- Language
- en
- Open access
- gold
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- Flasche, S., Van Hoek, A. J., Sheasby, E., Waight, P., Andrews, N., Sheppard, C., George, R., & Miller, E. (2011). Effect of Pneumococcal Conjugate Vaccination on Serotype-Specific Carriage and Invasive Disease in England: A Cross-Sectional Study. PLoS Medicine. https://doi.org/10.1371/journal.pmed.1001017
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