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Scaling Up Global Health Interventions: A Proposed Framework for Success

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Yamey, Gavin·2011·PLoS Medicine

DOI 10.1371/journal.pmed.1001049PMC PMC3125181

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Abstract

The adoption of the Millennium Development Goals-coupled with the recent rise in international aid for health-has catalyzed interest in improving the science of scale-up [1].Global health researchers have realized the need for ''a quantitative, scientific framework to guide health-care scale-up in developing countries'' [2], a need that has begun to draw the attention of donors [3].Low-and middle-income countries (LMICs) have begun to study effective ways to deliver proven interventions at scale [4,5].Thus, there are promising signs that a ''science of large-scale change in global health'' is emerging [5].In this Essay, I draw upon key themes in this emerging science to propose a framework for explaining successful scale-up.This framework is aimed at planners of scale-up processes to use in thinking about strategies for implementing a new program, policy, or intervention to scale.The term ''scaling up'' is now widely used in the public health literature, but there is no agreed definition.The term is primarily used, say Mangham and Hanson, to describe ''the ambition or process of expanding the coverage of health interventions '' [6], a working definition that I use in this article.The Essay section contains opinion pieces on topics of broad interest to a general medical audience.

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Haines, A., Sanders, D., Lehmann, U., Rowe, A. K., Lawn, J. E., Jan, S., Walker, D. G., & Bhutta, Z. (2007) · The Lancet · doi:10.1016/s0140-6736(07)60325-0 · Cited by 911
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References
(2021) · Emerald Group Publishing Limited eBooks · doi:10.1108/978-1-83909-630-320211009
8. Transnational Scale Up of Services in Global Health
Shahin, I., Sohal, R., Ginther, J., Hayden, L., MacDonald, J. A., Mossman, K., Parikh, H., McGahan, A. M., Mitchell, W., & Bhattacharyya, O. (2018) · University of Toronto Press eBooks · doi:10.3138/9781487515904-011
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Murphy, J., Nguyen, V. C., Chau, L. W., O’Neil, J., Hoi, N. V., & Minas, H. (2021) · Springer eBooks · doi:10.1007/978-3-030-57296-9_83
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Scaling-up Telemedicine: Challenges and Opportunities Seen in ASEAN
Uy, K. N., Co, F. A., & Bagon, A. C. (2024) · Asian journal of public health practice. · doi:10.4103/ajphp.ajphp_14_24
Facilitating and Constraining Factors for Achievement of Strategic Health Sector Results: Findings From a Qualitative Study of 15 Councils in Tanzania
Jiyenze, M. K., Tundui, C. S., & Mollel, H. A. (2024) · The International Journal of Health Planning and Management · doi:10.1002/hpm.3894
Incremental Cost for a Package to Strengthen Health Systems for Small and Sick Newborn Care in Four Sub-Saharan African Countries Implementing with NEST360Preprint
Tarus, A., Kumar, M. B., Penzias, R. E., Kamuyu, R., Cross, J., Sipalo, M., Gicheha, E., Bohne, C. A., Okello, G. R., Macharia, W., et al. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5247980
Global Health
McBride, H. E., Hotez, P. J., & Harrison, G. J. D. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-82763-8.00247-8
Planning for scale: analysis of adaptations and contextual factors influencing scale-up of the QUALI-DEC intervention to optimize caesarean section use
El-Halabi, S., Hanson, C., Dumont, A., Cleeve, A., Alvesson, H. M., Kaboré, C., Carroli, G., Lumbiganon, P., Mac, Q. N. H., Betrán, A. P., et al. (2025) · Implementation Science Communications · doi:10.1186/s43058-025-00737-6
Implementation Science in Action: A Comprehensive Analysis of the Sampark Swasthya Model for Community-Integrated Primary Healthcare in Resource-Limited Settings
Pallathadka, H., & Roy, P. D. (2025) · Integrated Journal for Research in Arts and Humanities · doi:10.55544/ijrah.5.3.47
Case Study of Nigeria’s experience scaling up chlorhexidine use in newborns, 2016-2021: analysis of implementation of actions to support scale-up and progress towards institutionalizationPreprint
Ricca, J., Badmus, O., Adeniran, B., James, F., Jatau, A. A., Iyemi, E., Orobaton, N., Ghiron, L., Kim, Y., Mohan, D., et al. (2025) · medRxiv · doi:10.1101/2025.10.22.25338605
Synthesis of conceptual, methodological and pedagogical works on scaling up complex public health interventions: a scoping review
Stevens, N., & Alla, F. (2025) · BMC Public Health · doi:10.1186/s12889-025-25040-w
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An implementation strategy bundle to improve home visit quality of the national child development program in Brazil: an implementation feasibility trial
Brentani, A., Westgard, C. M., Chang-Lopez, S. M., Onofre, A. C., Peres, N. V., Bessa, L., Colagrossi, A. L. R., dos Santos, J. A., Cunha, D. F. S., Haidar, J., et al. (2026) · Implementation Science Communications · doi:10.1186/s43058-026-00994-z
Interventions for enhancing child survival practices among caregivers of under-five children in Sub-Saharan Africa: a scoping review
Ibor, G. O., Oyakhilome, V., & Atulomah, N. O. (2025) · BMC Public Health · doi:10.1186/s12889-025-25627-3 · Cited by 3
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Authors: Yamey, G.
Corresponding author: Yamey, Gavin
ORCID: Yamey, Gavin
Venue: PLoS Medicine
Publisher: Public Library of Science (PLoS)
Published: 2011-06-28
Volume: 8
Issue: 6
Pages: e1001049
ISSN: 1549-1277 (ISSN-L)
1549-1676
DOI: 10.1371/journal.pmed.1001049
PMC: PMC3125181
OpenAlex: W2017349284
Cited by: 295
References: 43
Citations by year: 2026: 15 · 2025: 17 · 2024: 26 · 2023: 27 · 2022: 12 · 2021: 36 · 2020: 29 · 2019: 22 · 2018: 19 · 2017: 17 · 2016: 11 · 2015: 20 · 2014: 13 · 2013: 14 · 2012: 16
FWCI: 26.11
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS Medicine (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
RePEc: Research Papers in Economics (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Funders: Bill and Melinda Gates Foundation
Global Fund to Fight AIDS, Tuberculosis and Malaria
Topics: Health Sciences › Health Professions › General Health Professions › Health Policy Implementation Science
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Global Health and Surgery
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Healthcare Systems and Reforms
Keywords: scale-up, global health interventions, low- and middle-income countries, international health aid, Millennium Development Goals, health program implementation, health policy, intervention coverage
MeSH terms: Community Health Services, Delivery of Health Care, Health Policy, Health Services Research, Humans, International Agencies, Global Health

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Scaling Up Global Health Interventions: A Proposed Framework for Success

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