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Cited by 559

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children

Open access
Kilpeläinen, Tuomas O., Qi, Lu, Brage, Soren, Sharp, Stephen J., Sonestedt, Emily, Demerath, Ellen, Ahmad, Tariq, Mora, Samia, Kaakinen, Marika, Sandholt, Camilla Helene, Holzapfel, Christina, Autenrieth, Christine S., Hyppönen, Elina, Cauchi, Stéphane, He, Meian, Kutalik, Zoltan, Kumari, Meena, Stančáková, Alena, Meidtner, Karina, Balkau, Beverley, Tan, Jonathan T., Mangino, Massimo, Timpson, Nicholas J., Song, Yiqing, Zillikens, M. Carola, Jablonski, Kathleen A., Garcia, Melissa E., Johansson, Stefan, Bragg-Gresham, Jennifer L., Wu, Ying, van Vliet-Ostaptchouk, Jana V., Onland-Moret, N. Charlotte, Zimmermann, Esther, Rivera, Natalia V., Tanaka, Toshiko, Stringham, Heather M., Silbernagel, Günther, Kanoni, Stavroula, Feitosa, Mary F., Snitker, Soren, Ruiz, Jonatan R., Metter, Jeffery, Larrad, Maria Teresa Martinez, Atalay, Mustafa, Hakanen, Maarit, Amin, Najaf, Cavalcanti-Proença, Christine, Grøntved, Anders, Hallmans, Göran, Jansson, John-Olov, Kuusisto, Johanna, Kähönen, Mika, Lutsey, Pamela L., Nolan, John J., Palla, Luigi, Pedersen, Oluf, Pérusse, Louis, Renström, Frida, Scott, Robert A., Shungin, Dmitry, Sovio, Ulla, Tammelin, Tuija H., Rönnemaa, Tapani, Lakka, Timo A., Uusitupa, Matti, Rios, Manuel Serrano, Ferrucci, Luigi, Bouchard, Claude, Meirhaeghe, Aline, Fu, Mao, Walker, Mark, Borecki, Ingrid B., Dedoussis, George V., Fritsche, Andreas, Ohlsson, Claes, Boehnke, Michael, Bandinelli, Stefania, van Duijn, Cornelia M., Ebrahim, Shah, Lawlor, Debbie A., Gudnason, Vilmundur, Harris, Tamara B., Sørensen, Thorkild I. A., Mohlke, Karen L., Hofman, Albert, Uitterlinden, André G., Tuomilehto, Jaakko, Lehtimäki, Terho, Raitakari, Olli, Isomaa, Bo, Njølstad, Pål R., Florez, Jose C., Liu, Simin, Ness, Andy, Spector, Timothy D., Tai, E. Shyong, Froguel, Philippe, Boeing, Heiner, Laakso, Markku, Marmot, Michael, Bergmann, Sven, Power, Chris, Khaw, Kay-Tee, Chasman, Daniel, Ridker, Paul, Hansen, Torben, Monda, Keri L., Illig, Thomas, Järvelin, Marjo-Riitta, Wareham, Nicholas J., Hu, Frank B., Groop, Leif C., Orho-Melander, Marju, Ekelund, Ulf, Franks, Paul W., Loos, Ruth J. F.·2011·PLoS Medicine
DOI 10.1371/journal.pmed.1001116
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Abstract

BACKGROUND: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n = 218,166) and nine studies of children and adolescents (n = 19,268). METHODS AND FINDINGS: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r(2)>0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO×PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A-) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26), but PA attenuated this effect (p(interaction) = 0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio = 1.22/allele, 95% CI 1.19-1.25) than in the inactive group (odds ratio = 1.30/allele, 95% CI 1.24-1.36). No such interaction was found in children and adolescents. CONCLUSIONS: The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity.

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Authors
Kilpeläinen, T. O., Qi, L., Brage, S., Sharp, S. J., Sonestedt, E., Demerath, E., Ahmad, T., Mora, S., Kaakinen, M., Sandholt, C. H., Holzapfel, C., Autenrieth, C. S., Hyppönen, E., Cauchi, S., He, M., Kutalik, Z., Kumari, M., Stančáková, A., Meidtner, K., Balkau, B., Tan, J. T., Mangino, M., Timpson, N. J., Song, Y., Zillikens, M. C., Jablonski, K. A., Garcia, M. E., Johansson, S., Bragg-Gresham, J. L., Wu, Y., van Vliet-Ostaptchouk, J. V., Onland-Moret, N. C., Zimmermann, E., Rivera, N. V., Tanaka, T., Stringham, H. M., Silbernagel, G., Kanoni, S., Feitosa, M. F., Snitker, S., Ruiz, J. R., Metter, J., Larrad, M. T. M., Atalay, M., Hakanen, M., Amin, N., Cavalcanti-Proença, C., Grøntved, A., Hallmans, G., Jansson, J.-O., Kuusisto, J., Kähönen, M., Lutsey, P. L., Nolan, J. J., Palla, L., Pedersen, O., Pérusse, L., Renström, F., Scott, R. A., Shungin, D., Sovio, U., Tammelin, T. H., Rönnemaa, T., Lakka, T. A., Uusitupa, M., Rios, M. S., Ferrucci, L., Bouchard, C., Meirhaeghe, A., Fu, M., Walker, M., Borecki, I. B., Dedoussis, G. V., Fritsche, A., Ohlsson, C., Boehnke, M., Bandinelli, S., van Duijn, C. M., Ebrahim, S., Lawlor, D. A., Gudnason, V., Harris, T. B., Sørensen, T. I. A., Mohlke, K. L., Hofman, A., Uitterlinden, A. G., Tuomilehto, J., Lehtimäki, T., Raitakari, O., Isomaa, B., Njølstad, P. R., Florez, J. C., Liu, S., Ness, A., Spector, T. D., Tai, E. S., Froguel, P., Boeing, H., Laakso, M., Marmot, M., Bergmann, S., Power, C., Khaw, K.-T., Chasman, D., Ridker, P., Hansen, T., Monda, K. L., Illig, T., Järvelin, M.-R., Wareham, N. J., Hu, F. B., Groop, L. C., Orho-Melander, M., Ekelund, U., Franks, P. W., & Loos, R. J. F.
Venue
PLoS Medicine
Publisher
Public Library of Science (PLoS)
Published
2011-11-01
Volume
8
Issue
11
Pages
e1001116
ISSN
  • 1549-1277 (ISSN-L)
  • 1549-1676
DOI
10.1371/journal.pmed.1001116
OpenAlex
W2142435658
Cited by
559
References
43
FWCI
4.34
Type
journal article
Language
en
Open access
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CoChat. (2026). Citation check: Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children. https://app.cochat.ai/papers/10.1371/journal.pmed.1001116
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Kilpeläinen, T. O., Qi, L., Brage, S., Sharp, S. J., Sonestedt, E., Demerath, E., Ahmad, T., Mora, S., Kaakinen, M., Sandholt, C. H., Holzapfel, C., Autenrieth, C. S., Hyppönen, E., Cauchi, S., He, M., Kutalik, Z., Kumari, M., Stančáková, A., Meidtner, K., . . . Loos, R. J. F. (2011). Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children. PLoS Medicine. https://doi.org/10.1371/journal.pmed.1001116

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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