Genetic Control of Obesity and Gut Microbiota Composition in Response to High-Fat, High-Sucrose Diet in Mice
Open accessAbstract
Obesity is a highly heritable disease driven by complex interactions between genetic and environmental factors. Human genome-wide association studies (GWAS) have identified a number of loci contributing to obesity; however, a major limitation of these studies is the inability to assess environmental interactions common to obesity. Using a systems genetics approach, we measured obesity traits, global gene expression, and gut microbiota composition in response to a high-fat/high-sucrose (HF/HS) diet of more than 100 inbred strains of mice. Here we show that HF/HS feeding promotes robust, strain-specific changes in obesity that are not accounted for by food intake and provide evidence for a genetically determined set point for obesity. GWAS analysis identified 11 genome-wide significant loci associated with obesity traits, several of which overlap with loci identified in human studies. We also show strong relationships between genotype and gut microbiota plasticity during HF/HS feeding and identify gut microbial phylotypes associated with obesity.
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Similar changes in the phylum were observed with mice fed on a high-fat and high-sucrose diet.
“Similar changes in the phylum were observed with mice fed on a high-fat and high-sucrose diet (Parks et al., 2013).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Parks et al., 2013
Parks and coworkers studied the effects of a high fat, high sucrose diet across about 100 different inbred strains of mice.
“For example, Parks and coworkers [31, 32] recently studied the effects of a high fat, high sucrose diet across about 100 different inbred strains of mice.”
From Multi-omics approaches to disease (2017) · cites this paper as [31]
Parks et al. identified pathways and genes contributing to diet-induced obesity and diabetes by examining global gene expression in multiple tissues and metabolites in plasma.
“By examining global gene expression in multiple tissues and metabolites in plasma, they were able to identify pathways and genes contributing to diet-induced obesity and diabetes.”
From Multi-omics approaches to disease (2017) · cites this paper as [31]
Recent multi-omic studies have revealed an impact of gut microbiota on host responses to dietary challenge and on epigenetic programming.
“Recent multi-omic studies [31, 33, 34] have revealed an impact of gut microbiota on host responses to dietary challenge and on epigenetic programming.”
From Multi-omics approaches to disease (2017) · cites this paper as [31]
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Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
UniFrac: a New Phylogenetic Method for Comparing Microbial Communities
Lozupone, C., & Knight, R. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.12.8228-8235.2005 · Cited by 8,227 · see citing works
Self-citationA core gut microbiome in obese and lean twins
Turnbaugh, P. J., Hamady, M., Yatsunenko, T., Cantarel, B. L., Duncan, A., Ley, R. E., Sogin, M. L., Jones, W. J., Roe, B. A., Affourtit, J. P., et al. (2009) · Nature · doi:10.1038/nature07540 · Cited by 7,823 · see citing works
Self-citationHuman gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815 · see citing works
Self-citationGenetics of Food Intake Self-Regulation in Childhood: Literature Review and Research Opportunities
Faith, M. S., Carnell, S., & Kral, T. V. E. (2013) · Human Heredity · doi:10.1159/000353879 · Cited by 7,628 · see citing works
A metagenome-wide association study of gut microbiota in type 2 diabetes
Qin, J., Li, Y., Cai, Z., Li, S., Zhu, J., Zhang, F., Liang, S., Zhang, W., Guan, Y., Shen, D., et al. (2012) · Nature · doi:10.1038/nature11450 · Cited by 6,762 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
Self-citationGut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597 · see citing works
Self-citationPrevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010.
Flegal, K., Carroll, M., Kit, B., & Ogden, C. (2012) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.2012.39 · Cited by 5,523 · see citing works
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works
Common SNPs explain a large proportion of the heritability for human height
Yang, J., Benyamin, B., McEvoy, B. P., Gordon, S., Henders, A. K., Nyholt, D. R., Madden, P. A., Heath, A. C., Martin, N. G., Montgomery, G. W., et al. (2010) · Nature Genetics · doi:10.1038/ng.608 · Cited by 4,446 · see citing works
Finucane, M. M., Stevens, G. A., Cowan, M. J., Danaei, G., Lin, J. K., Paciorek, C. J., Singh, G. M., Gutierrez, H. R., Lu, Y., Bahalim, A. N., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(10)62037-5 · Cited by 4,050 · see citing works
The impact of the gut microbiota on human health: an integrative view
Clemente, J. C., Ursell, L. K., Parfrey, L. W., & Knight, R. (2012) · Cell · doi:10.1016/j.cell.2012.01.035 · Cited by 3,710 · see citing works
Self-citationRayman, M. P. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61452-9 · Cited by 3,563 · see citing works
The Effect of Diet on the Human Gut Microbiome: A Metagenomic Analysis in Humanized Gnotobiotic Mice
Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I. (2009) · Science Translational Medicine · doi:10.1126/scitranslmed.3000322 · Cited by 3,058 · see citing works
Self-citationAssociation analyses of 249,796 individuals reveal 18 new loci associated with body mass index
MAGIC, Speliotes, E. K., on behalf of Procardis Consortium, Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., Allen, H. L., Lindgren, C. M., et al. (2010) · Nature Genetics · doi:10.1038/ng.686 · Cited by 2,912 · see citing works
Introduction to Robust Estimation and Hypothesis Testing
Wilcox, R. R. (2012) · Elsevier eBooks · doi:10.1016/c2010-0-67044-1 · Cited by 2,102 · see citing works
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068 · see citing works
Self-citationEfficient Control of Population Structure in Model Organism Association Mapping
Kang, H. M., Zaitlen, N., Wade, C. M., Kirby, A. W., Heckerman, D. E., Daly, M. J., & Eskin, E. (2008) · Genetics · doi:10.1534/genetics.107.080101 · Cited by 1,848 · see citing works
Self-citationTwelve type 2 diabetes susceptibility loci identified through large-scale association analysis
The MAGIC investigators, Voight, B. F., The GIANT Consortium, Scott, L. J., Steinthorsdottir, V., Morris, A. P., Dina, C., Welch, R. P., Zeggini, E., Huth, C., et al. (2010) · Nature Genetics · doi:10.1038/ng.609 · Cited by 1,761 · see citing works
Sugar-Sweetened Beverages, Obesity, Type 2 Diabetes Mellitus, and Cardiovascular Disease Risk
Malik, V. S., Popkin, B. M., Bray, G. A., Després, J.-P., & Hu, F. B. (2010) · Circulation · doi:10.1161/circulationaha.109.876185 · Cited by 1,641 · see citing works
Mouse genomic variation and its effect on phenotypes and gene regulation.
Keane, T. M., Goodstadt, L., Danecek, P., White, M. A., Wong, K., Yalcin, B., Heger, A., Agam, A., Slater, G., Goodson, M., et al. (2011) · Nature · doi:10.1038/nature10413 · Cited by 1,580 · see citing works
Self-citationThe mystery of missing heritability: Genetic interactions create phantom heritability
Zuk, O., Hechter, E., Sunyaev, S. R., & Lander, E. S. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119675109 · Cited by 1,542 · see citing works
Thorleifsson, G., Walters, G. B., Gudbjartsson, D. F., Steinthorsdottir, V., Sulem, P., Helgadottir, A., Styrkarsdottir, U., Gretarsdottir, S., Thorlacius, S., Jonsdottir, I., et al. (2009) · Nature Genetics · doi:10.1038/ng.274 · Cited by 1,375 · see citing works
Benson, A. K., Kelly, S. A., Legge, R., Ma, F., Low, S. J., Kim, J., Zhang, M., Oh, P. L., Nehrenberg, D., Hua, K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1007028107 · Cited by 1,314 · see citing works
The Response to Long-Term Overfeeding in Identical Twins
Bouchard, C., Tremblay, A., Després, J.-P., Nadeau, A., Lupien, P. J., Thériault, G., Dussault, J., Moorjani, S., Pinault, S., & Fournier, G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005243222101 · Cited by 1,278 · see citing works
Initial impact of the sequencing of the human genome
Lander, E. S. (2011) · Nature · doi:10.1038/nature09792 · Cited by 1,044 · see citing works
Stunkard, A. J. (1986) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1986.03380010055024 · Cited by 912 · see citing works
Variations in DNA elucidate molecular networks that cause disease
Chen, Y., Zhu, J., Lum, P. Y., Yang, X., Pinto, S., MacNeil, D. J., Zhang, C., Lamb, J., Edwards, S., Sieberts, S. K., et al. (2008) · Nature · doi:10.1038/nature06757 · Cited by 887 · see citing works
Self-citationGenetics of body-weight regulation
Barsh, G. S., Farooqi, I. S., & O’Rahilly, S. (2000) · Nature · doi:10.1038/35007519 · Cited by 775 · see citing works
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Þorleifsson, G., Jackson, A., Allen, H. L., Lindgren, C. M., Luan, J., Mägi, R., et al. (2010) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/d3bn-7g86 · Cited by 767 · see citing works
Meyre, D., Delplanque, J., Chèvre, J.-C., Lecœur, C., Lobbens, S., Gallina, S., Durand, E., Vatin, V., Degraeve, F., Cavalcanti-Proença, C., et al. (2009) · Nature Genetics · doi:10.1038/ng.301 · Cited by 648 · see citing works
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
Herman, M. A., Peroni, O. D., Villoria, J., Schön, M. R., Abumrad, N. A., Blüher, M., Klein, S., & Kahn, B. B. (2012) · Nature · doi:10.1038/nature10986 · Cited by 599 · see citing works
Kilpeläinen, T. O., Qi, L., Brage, S., Sharp, S. J., Sonestedt, E., Demerath, E. W., Ahmad, T., Mora, S., Kaakinen, M., Sandholt, C. H., et al. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001116 · Cited by 559 · see citing works
Strategies for mapping and cloning quantitative trait genes in rodents
Jonathan Flint, C., Valdar, W. S. J., Shifman, S., & Mott, R. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1576 · Cited by 497 · see citing works
Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity
Ouchi, N., Higuchi, A., Ohashi, K., Oshima, Y., Gokce, N., Shibata, R., Akasaki, Y., Shimono, A., & Walsh, K. (2010) · Science · doi:10.1126/science.1188280 · Cited by 490 · see citing works
Introduction to Robust Estimation and Hypothesis Testing
(2005) · Technometrics · doi:10.1198/tech.2005.s334 · Cited by 376 · see citing works
Small, K. S., Grundberg, E., Soranzo, N., Ahmadi, K. R., Spector, T. D., Shin, S., Deloukas, P., Hedman, Å. K., Lindgren, C. M., McCarthy, M. I., et al. (2011) · Nature Genetics · doi:10.1038/ng.833 · Cited by 320 · see citing works
Speakman, J. R., Levitsky, D. A., Allison, D. B., Bray, M. S., de Castro, J. M., Clegg, D. J., Clapham, J. C., Dulloo, A. G., Gruer, L. D., Haw, S. J., et al. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.008698 · Cited by 316 · see citing works
A high-resolution association mapping panel for the dissection of complex traits in micePreprint
Bennett, B. J., Farber, C. R., Orozco, L. D., Kang, H. M., Ghazalpour, A., Siemers, N. O., Neubauer, M., Neuhaus, I., Yordanova, R., Guan, B., et al. (2010) · Genome Research · doi:10.1101/gr.099234.109 · Cited by 314 · see citing works
Self-citationIdentification and Characterization of a Sphingolipid Δ4-Desaturase Family
Ternes, P., Franke, S., Zähringer, U., Sperling, P., & Heinz, E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202947200 · Cited by 293 · see citing works
Fox, C. S., Liu, Y., White, C. C., Feitosa, M. F., Smith, A. V., Heard‐Costa, N. L., Lohman, K., Johnson, A. D., Foster, M. C., Greenawalt, D. M., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002695 · Cited by 276 · see citing works
Barrett, M. L., & Udani, J. K. (2011) · Nutrition Journal · doi:10.1186/1475-2891-10-24 · Cited by 270 · see citing works
Sonestedt, E., Roos, C., Gullberg, B., Ericson, U., Wirfält, E., & Orho‐Melander, M. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27958 · Cited by 266 · see citing works
Quantitative magnetic resonance (QMR) method for bone and whole-body-composition analysis
Taicher, G. Z., Tinsley, F. C., Reiderman, A., & Heiman, M. L. (2003) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-003-2224-3 · Cited by 257 · see citing works
Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis
Shao, H., Burrage, L. C., Sinasac, D. S., Hill, A. E., Ernest, S. R., O’Brien, W. E., Courtland, H., Jepsen, K. J., Kirby, A. W., Kulbokas, E. J., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810388105 · Cited by 256 · see citing works
Adipocyte metabolism and obesity
Attie, A., & Scherer, P. E. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800057-jlr200 · Cited by 225 · see citing works
Murine Gut Microbiota Is Defined by Host Genetics and Modulates Variation of Metabolic Traits
McKnite, A. M., Pérez-Muñoz, M. E., Lu, L., Williams, E. G., Brewer, S., Andreux, P. A., Bastiaansen, J. W. M., Wang, X., Kachman, S. D., Auwerx, J. H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039191 · Cited by 222 · see citing works
Demirkan, A., van Duijn, C. M., Ugocsai, P., Isaacs, A., Pramstaller, P. P., Liebisch, G., Wilson, J. F., Johansson, Å., Rudan, I., Aulchenko, Y. S., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002490 · Cited by 205 · see citing works
Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis
Xu, X., Carlson, B. A., Irons, R., et al. (2007) · Biochemical Journal · doi:10.1042/bj20070165 · Cited by 193 · see citing works
Genome-wide association studies in mice
Flint, J., & Eskin, E. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3335 · Cited by 188 · see citing works
Self-citationThe SPTLC3 Subunit of Serine Palmitoyltransferase Generates Short Chain Sphingoid Bases
Hornemann, T., Penno, A., Rütti, M. F., Ernst, D., Pfiffner, F. K., Rohrer, L., & von Eckardstein, A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.023192 · Cited by 184 · see citing works
CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance
Carine Chavey, A., Lazennec, G., Lagarrigue, S., Clapé, C., Iankova, I., Teyssier, J., Annicotte, J., Schmidt, J., Mataki, C., Yamamoto, H., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.03.002 · Cited by 182 · see citing works
Human-Associated Microbial Signatures: Examining Their Predictive Value
Knights, D., Parfrey, L. W., Zaneveld, J., Lozupone, C., & Knight, R. D. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.09.003 · Cited by 156 · see citing works
Self-citationSmith, E. N., Chen, W., Kähönen, M. A. P., Kettunen, J., Lehtimäki, T. J., Peltonen, L., Raitakari, O. T., Salem, R. M., Schork, N. J., Shaw, M., et al. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001094 · Cited by 146 · see citing works
Human Carbonyl Reductase 1 Is an S-Nitrosoglutathione Reductase
Bateman, R. L., Rauh, D., Tavshanjian, B., & Shokat, K. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m807125200 · Cited by 136 · see citing works
Obesity susceptibility loci and dietary intake in the Look AHEAD Trial
McCaffery, J. M., Papandonatos, G. D., Peter, I., Huggins, G. S., Raynor, H. A., Delahanty, L. M., Cheskin, L. J., Balasubramanyam, A., Wagenknecht, L. E., & Wing, R. R. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.026955 · Cited by 124 · see citing works
Abnormal regulation of the leptin gene in the pathogenesis of obesity.
Ioffe, E., Moon, B., Connolly, E., & Friedman, J. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11852 · Cited by 117 · see citing works
Farber, C. R., Bennett, B. J., Orozco, L. D., Zou, W., Lira, A. K., Kostem, E., Kang, H. M., Furlotte, N. A., Berberyan, A., Ghazalpour, A., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002038 · Cited by 113 · see citing works
Self-citationGLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility
Guan, X., Shi, X., Li, X., Chang, B. H., Wang, Y., Li, D., & Chan, L. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00245.2012 · Cited by 76 · see citing works
Bhatnagar, S., Oler, A. T., Rabaglia, M. E., Stapleton, D. S., Schueler, K. L., Truchan, N. A., Worzella, S. L., Stoehr, J. P., Clee, S. M., Yandell, B. S., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002323 · Cited by 75 · see citing works
Dokmanovic-Chouinard, M., Chung, W. K., Chèvre, J.-C., Watson, E., Yonan, J., Wiegand, B., Bromberg, Y., Wakae, N., Wright, C. V. E., Overton, J. D., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000137 · Cited by 65 · see citing works
Combined Analyses of 20 Common Obesity Susceptibility Variants
Sandholt, C. H., Sparsø, T., Grarup, N., Albrechtsen, A., Almind, K., Hansen, L., Toft, U., Jørgensen, T., Hansen, T. F., & Pedersen, O. B. (2010) · Diabetes · doi:10.2337/db09-1042 · Cited by 60 · see citing works
Fine-Mapping Gene-by-Diet Interactions on Chromosome 13 in a LG/J × SM/J Murine Model of Obesity
Ehrich, T. H., Hrbek, T., Kenney‐Hunt, J. P., Pletscher, L. S., Wang, B., Semenkovich, C. F., & Cheverud, J. M. (2005) · Diabetes · doi:10.2337/diabetes.54.6.1863 · Cited by 51 · see citing works
Lawson, H. A., Cady, J., Partridge, C., Wolf, J. B., Semenkovich, C. F., & Cheverud, J. M. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002256 · Cited by 49 · see citing works
Decreased Npc1 Gene Dosage in Mice Is Associated With Weight Gain
Jelínek, D., Heidenreich, R. A., Erickson, R. P., et al. (2009) · Obesity · doi:10.1038/oby.2009.415 · Cited by 39 · see citing works
The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity
Buchner, D. A., Geisinger, J. M., Glazebrook, P. A., Morgan, M. G., Spiezio, S. H., Kaiyala, K. J., Schwartz, M. W., Sakurai, T., Furley, A. J., Kunze, D. L., et al. (2012) · Mammalian Genome · doi:10.1007/s00335-012-9400-8 · Cited by 38 · see citing works
York, B., Truett, A. A., Monteiro, M. P., et al. (1999) · Mammalian Genome · doi:10.1007/s003359901023 · Cited by 34 · see citing works
Genetic resistance to diet-induced obesity in chromosome substitution strains of mice
Burrage, L. C., Hill‐Baskin, A. E., Sinasac, D. S., Singer, J. B., Croniger, C. M., Kirby, A. W., Kulbokas, E. J., Daly, M. J., Lander, E. S., Broman, K. W., et al. (2010) · Mammalian Genome · doi:10.1007/s00335-010-9247-9 · Cited by 34 · see citing works
Ehrich, T. H., Kenney‐Hunt, J. P., Pletscher, L. S., et al. (2005) · Genetics Research · doi:10.1017/s0016672305007603 · Cited by 21 · see citing works
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Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286 · see citing works
Multi-omics approaches to disease
Hasin, Y., Seldin, M., & Lusis, A. (2017) · Genome Biology · doi:10.1186/s13059-017-1215-1 · Cited by 2,953 · see citing works
Self-citationMicrobiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits
De Vadder, F., Kovatcheva-Datchary, P., Goncalves, D., Vinera, J., Zitoun, C., Duchampt, A., Bäckhed, F., & Mithieux, G. (2014) · Cell · doi:10.1016/j.cell.2013.12.016 · Cited by 2,200 · see citing works
How informative is the mouse for human gut microbiota research?
Nguyen, T. L. A., Vieira-Silva, S., Liston, A., & Raes, J. (2015) · Disease Models & Mechanisms · doi:10.1242/dmm.017400 · Cited by 1,334 · see citing works
“Moreover, a genome-wide association study of obesity in mice identified genes associated with obesity in mice that overlap with some genes involved in human obesity (Parks et al., 2013).”
BackgroundDiet dominates host genotype in shaping the murine gut microbiota
Carmody, R. N., Gerber, G. K., Luevano, J. M., Gatti, D. M., Somes, L., Svenson, K. L., & Turnbaugh, P. J. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2014.11.010 · Cited by 1,103 · see citing works
FXR is a molecular target for the effects of vertical sleeve gastrectomy
Ryan, K. K., Tremaroli, V., Clemmensen, C., Kovatcheva-Datchary, P., Myronovych, A., Karns, R., Wilson-Pérez, H. E., Sandoval, D. A., Kohli, R., Bäckhed, F., et al. (2014) · Nature · doi:10.1038/nature13135 · Cited by 931 · see citing works
Bile acid signaling in metabolic disease and drug therapy
Li, T., & Chiang, J. Y. L. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008201 · Cited by 935 · see citing works
Diet and feeding pattern affect the diurnal dynamics of the gut microbiome
Zarrinpar, A., Chaix, A., Yooseph, S., & Panda, S. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.11.008 · Cited by 926 · see citing works
Diet-microbiota interactions and personalized nutrition
Kolodziejczyk, A. A., Zheng, D., & Elinav, E. (2019) · Nature Reviews Microbiology · doi:10.1038/s41579-019-0256-8 · Cited by 879 · see citing works
Sex differences and hormonal effects on gut microbiota composition in mice
Org, E., Mehrabian, M., Parks, B. W., Shipkova, P., Liu, X., Drake, T. A., & Lusis, A. J. (2016) · Gut Microbes · doi:10.1080/19490976.2016.1203502 · Cited by 796 · see citing works
Self-citationMicrobiota and Host Nutrition across Plant and Animal Kingdoms
Hacquard, S., Garrido-Oter, R., González, A., Spaepen, S., Ackermann, G., Lebeis, S., McHardy, A. C., Dangl, J. L., Knight, R., Ley, R., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.04.009 · Cited by 779 · see citing works
Self-citationThe effect of host genetics on the gut microbiome
Bonder, M. J., Kurilshikov, A., Tigchelaar, E. F., Mujagic, Z., Imhann, F., Vila, A. V., Deelen, P., Vatanen, T., Schirmer, M., Smeekens, S. P., et al. (2016) · Nature Genetics · doi:10.1038/ng.3663 · Cited by 819 · see citing works
Biochemical and cellular properties of insulin receptor signalling
Haeusler, R. A., McGraw, T. E., & Accili, D. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.89 · Cited by 739 · see citing works
Systems genetics approaches to understand complex traits
Civelek, M., & Lusis, A. J. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3575 · Cited by 621 · see citing works
Self-citationAgus, A., Denizot, J., Thévenot, J., Martinez-Medina, M., Massier, S., Sauvanet, P., Bernalier-Donadille, A., Denis, S., Hofman, P., Bonnet, R., et al. (2016) · Scientific Reports · doi:10.1038/srep19032 · Cited by 477 · see citing works
The gut microbiota in human energy homeostasis and obesity
Rosenbaum, M., Knight, R., & Leibel, R. L. (2015) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2015.07.002 · Cited by 450 · see citing works
Self-citationCircadian disorganization alters intestinal microbiota
Voigt, R. M., Forsyth, C. B., Green, S. J., Mutlu, E., Engen, P., Vitaterna, M. H., Turek, F. W., & Keshavarzian, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097500 · Cited by 439 · see citing works
Genetic and environmental control of host-gut microbiota interactions
Org, E., Parks, B. W., Joo, J. W. J., Emert, B., Schwartzman, W., Kang, E. Y., Mehrabian, M., Pan, C., Knight, R., Gunsalus, R., et al. (2015) · Genome Research · doi:10.1101/gr.194118.115 · Cited by 381 · see citing works
Self-citationFunctional Foods and Lifestyle Approaches for Diabetes Prevention and Management
Alkhatib, A., Tsang, C., Tiss, A., Bahorun, T., Arefanian, H., Barake, R., Khadir, A., & Tuomilehto, J. (2017) · Nutrients · doi:10.3390/nu9121310 · Cited by 376 · see citing works
A healthy gastrointestinal microbiome is dependent on dietary diversity
Heiman, M. L., & Greenway, F. L. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.02.005 · Cited by 370 · see citing works
Breton, J., Tennoune, N., Lucas, N., Francois, M., Legrand, R., Jacquemot, J., Goichon, A., Guérin, C., Peltier, J., Pestel-Caron, M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.017 · Cited by 321 · see citing works
Schugar, R. C., Shih, D. M., Warrier, M., Helsley, R. N., Burrows, A., Ferguson, D., Brown, A. L., Gromovsky, A. D., Heine, M., Chatterjee, A., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.05.077 · Cited by 291 · see citing works
Self-citationGenetic Architecture of Insulin Resistance in the Mouse
Parks, B. W., Sallam, T., Mehrabian, M., Psychogios, N., Hui, S. T., Norheim, F., Castellani, L. W., Rau, C. D., Pan, C., Phun, J., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.01.002 · Cited by 249 · see citing works
Self-citationLow copy number of the salivary amylase gene predisposes to obesity
Falchi, M., El-Sayed Moustafa, J. S., Takousis, P., Pesce, F., Bonnefond, A., Andersson-Assarsson, J. C., Sudmant, P. H., Dorajoo, R., Al-Shafai, M. N., Bottolo, L., et al. (2014) · Nature Genetics · doi:10.1038/ng.2939 · Cited by 254 · see citing works
Fecal microbiota transplantation broadening its application beyond intestinal disorders
Xu, M.-Q. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i1.102 · Cited by 231 · see citing works
Dietary fat and gut microbiota interactions determine diet-induced obesity in mice
Kübeck, R., Bonet-Ripoll, C., Hoffmann, C., Walker, A., Müller, V. M., Schüppel, V. L., Lagkouvardos, I., Scholz, B., Engel, K.-H., Daniel, H., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.10.001 · Cited by 211 · see citing works
Host genotype and gut microbiome modulate insulin secretion and diet-induced metabolic phenotypes
Kreznar, J. H., Keller, M. P., Traeger, L. L., Rabaglia, M. E., Schueler, K. L., Stapleton, D. S., Zhao, W., Vivas, E. I., Yandell, B. S., Broman, A. T., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.01.062 · Cited by 177 · see citing works
Lusis, A. J., Seldin, M. M., Allayee, H., Bennett, B. J., Civelek, M., Davis, R. C., Eskin, E., Farber, C. R., Hui, S., Mehrabian, M., et al. (2016) · Journal of Lipid Research · doi:10.1194/jlr.r066944 · Cited by 158 · see citing works
Self-citationMechanistic links between gut microbial community dynamics, microbial functions and metabolic health
Ha, C. W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i44.16498 · Cited by 137 · see citing works
Moore, T. M., Zhou, Z., Cohn, W., Norheim, F., Lin, A. J., Kalajian, N., Strumwasser, A. R., Cory, K., Whitney, K., Ho, T., et al. (2019) · Molecular Metabolism · doi:10.1016/j.molmet.2018.11.012 · Cited by 131 · see citing works
Self-citationHughes, R. L., Kable, M. E., Marco, M., & Keim, N. L. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz049 · Cited by 117 · see citing works
Links between Dietary Protein Sources, the Gut Microbiota, and Obesity
Madsen, L., Myrmel, L. S., Fjære, E., Liaset, B., & Kristiansen, K. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.01047 · Cited by 110 · see citing works
The Gut Microbiome and Individual-Specific Responses to Diet
Leshem, A., Segal, E., & Elinav, E. (2020) · mSystems · doi:10.1128/msystems.00665-20 · Cited by 109 · see citing works
A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism
Seldin, M. M., Koplev, S., Rajbhandari, P., Vergnes, L., Rosenberg, G. M., Meng, Y., Pan, C., Phuong, T. M. N., Gharakhanian, R., Che, N., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.015 · Cited by 84 · see citing works
Self-citationFgr kinase is required for proinflammatory macrophage activation during diet-induced obesity
Acín-Pérez, R., Iborra, S., Martí-Mateos, Y., Cook, E. C. L., Conde-Garrosa, R., Petcherski, A., Muñoz, M. D. M., Martínez de Mena, R., Krishnan, K. C., Jiménez, C., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00273-8 · Cited by 83 · see citing works
Self-citationChaplin, A., Parra, P., Serra, F., & Palou, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0125091 · Cited by 79 · see citing works
Alam, M., Alam, Q., Kamal, M., Abuzenadah, A., & Haque, A. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660151 · Cited by 47 · see citing works
- Authors
- Parks, B. W., Nam, E., Org, E., Kostem, E., Norheim, F., Hui, S. T., Pan, C., Civelek, M., Rau, C. D., Bennett, B. J., Mehrabian, M., Ursell, L. K., He, A., Castellani, L. W., Zinker, B., Kirby, M., Drake, T. A., Drevon, C. A., Knight, R., Gargalovic, P., Kirchgessner, T., Eskin, E., & Lusis, A. J.
- Affiliations
- University of California, Los Angeles (US)
- University of North Carolina at Chapel Hill (US)
- University of Colorado Boulder (US)
- Bristol-Myers Squibb (United States) (US)
- University of Oslo (NO)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Parks, Brian W.
- Lusis, Aldons J.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 17
- Issue
- 1
- Pages
- 141-152
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3545283
- OpenAlex
- W1969839871
- Cited by
- 544
- References
- 72
- Citations by year
- 2026: 17 · 2025: 32 · 2024: 28 · 2023: 30 · 2022: 40 · 2021: 44 · 2020: 56 · 2019: 46 · 2018: 43 · 2017: 51 · 2016: 46 · 2015: 48 · 2014: 43 · 2013: 20
- FWCI
- 23.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- Howard Hughes Medical Institute
- American Heart Association
- Bristol-Myers Squibb
- National Institutes of Health (HL028481, T32-HD07228, HD07228)
- National Heart, Lung, and Blood Institute (HL3 0568, T32 HL-69766, P01HL030568, HL-028481, R00HL102223, T32HL069766, P01HL028481)
- National Institute of General Medical Sciences (T32-GM08759, T32GM008759, T32GM142607)
- National Institute of Diabetes and Digestive and Kidney Diseases (DP3DK094311, DK094311)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32-HD-07228, T32HD007228)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- obesity, gut microbiota, high-fat high-sugar diet, inbred mouse strains, genome-wide association loci, gene expression, diet-microbiome interactions
- MeSH terms
- Animals, Body Composition, Dietary Carbohydrates, Humans, Intestinal Mucosa, Obesity, Genome, Quantitative Trait Loci, Mice, Metagenome, Genome-Wide Association Study, Diet, High-Fat
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