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Measuring the Burden of Neglected Tropical Diseases: The Global Burden of Disease Framework

Open access
Mathers, Colin D., Ezzati, Majid, Lopez, Alan D.·2007·PLoS Neglected Tropical Diseases

Abstract

Reliable, comparable information about the main causes of disease and injury in populations, and how these are changing, is a critical input for debates about priorities in the health sector. Traditional sources of information about the descriptive epidemiology of diseases, injuries, and risk factors are generally incomplete, fragmented, and of uncertain reliability and comparability. The Global Burden of Disease (GBD) study has provided a conceptual and methodological framework to quantify and compare the health of populations using a summary measure of both mortality and disability, the disability-adjusted life year (DALY).This paper describes key features of the Global Burden of Disease analytic approach, which provides a standardized measurement framework to permit comparisons across diseases and injuries, as well as risk factors, and a systematic approach to the evaluation of data. The paper describes the evolution of the GBD, starting from the first study for the year 1990, summarizes the methodological improvements incorporated into GBD revisions for the years 2000-2004 carried out by the World Health Organization, and examines priorities and issues for the next major GBD study, funded by the Bill & Melinda Gates Foundation, and commencing in 2007.The paper presents an overview of summary results from the Global Burden of Disease study 2002, with a particular focus on the neglected tropical diseases, and also an overview of the comparative risk assessment for 26 global risk factors. Taken together, trypanosomiasis, Chagas disease, schistosomiasis, leishmaniasis, lymphatic filariasis, onchocerciasis, intestinal nematode infections, Japanese encephalitis, dengue, and leprosy accounted for an estimated 177,000 deaths worldwide in 2002, mostly in sub-Saharan Africa, and about 20 million DALYs, or 1.3% of the global burden of disease and injuries. Further research is currently underway to revise and update these estimates.

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Metadata

Authors
Mathers, C. D., Ezzati, M., & Lopez, A. D.
Venue
PLoS Neglected Tropical Diseases
Published
2007-11-07
Volume
1
Issue
2
Pages
e114
ISSN
  • 1935-2727 (ISSN-L)
  • 1935-2735
OpenAlex
W2156333745
Cited by
510
References
5
FWCI
15.89
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Measuring the Burden of Neglected Tropical Diseases: The Global Burden of Disease Framework. https://app.cochat.ai/papers/10.1371/journal.pntd.0000114
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Mathers, C. D., Ezzati, M., & Lopez, A. D. (2007). Measuring the Burden of Neglected Tropical Diseases: The Global Burden of Disease Framework. PLoS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0000114

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.