The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Low Efficacy of Single-Dose Albendazole and Mebendazole against Hookworm and Effect on Concomitant Helminth Infection in Lao PDR
Open accessAbstract
BACKGROUND: Albendazole and mebendazole are increasingly deployed for preventive chemotherapy targeting soil-transmitted helminth (STH) infections. We assessed the efficacy of single oral doses of albendazole (400 mg) and mebendazole (500 mg) for the treatment of hookworm infection in school-aged children in Lao PDR. Since Opisthorchis viverrini is co-endemic in our study setting, the effect of the two drugs could also be determined against this liver fluke. METHODOLOGY: We conducted a randomized, open-label, two-arm trial. In total, 200 children infected with hookworm (determined by quadruplicate Kato-Katz thick smears derived from two stool samples) were randomly assigned to albendazole (n=100) and mebendazole (n=100). Cure rate (CR; percentage of children who became egg-negative after treatment), and egg reduction rate (ERR; reduction in the geometric mean fecal egg count at treatment follow-up compared to baseline) at 21-23 days posttreatment were used as primary outcome measures. Adverse events were monitored 3 hours post treatment. PRINCIPAL FINDINGS: Single-dose albendazole and mebendazole resulted in CRs of 36.0% and 17.6% (odds ratio: 0.4; 95% confidence interval: 0.2-0.8; P=0.01), and ERRs of 86.7% and 76.3%, respectively. In children co-infected with O. viverrini, albendazole and mebendazole showed low CRs (33.3% and 24.2%, respectively) and moderate ERRs (82.1% and 78.2%, respectively). CONCLUSIONS/SIGNIFICANCE: Both albendazole and mebendazole showed disappointing CRs against hookworm, but albendazole cured infection and reduced intensity of infection with a higher efficacy than mebendazole. Single-dose administrations showed an effect against O. viverrini, and hence it will be interesting to monitor potential ancillary benefits of a preventive chemotherapy strategy that targets STHs in areas where opisthorchiasis is co-endemic. CLINICAL TRIAL REGISTRATION: Current Controlled Trials ISRCTN29126001.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Among various species of intestinal nematodes infecting humans, Ascaris lumbricoides is the most highly susceptible parasite species to albendazole and mebendazole [1,8–10,42–44] (Table 1).”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [44]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Recently, however, the 500 mg single dose regimen showed lower efficacies, 27.9% CR and 66.0% ERR in 2012 [44] (Table 1), 42.1% CR and 66.0% ERR in 2017 [43], and 44.4% CR and 80.7% ERR in 2017 [42].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [44]
The cited source says what the claim attributes to it.
In the citing paper
“A study in Lao PDR in 2012 reported only 33.3% CR and 67.0% ERR [44].”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [44]
The cited source says what the claim attributes to it.
In the citing paper
“Mebendazole showed poor efficacy for hookworms if used 500 mg only 1 time. Keiser and Utzinger [10] and Soukhathammavong et al. [44] reported the CRs of 500 mg single dose of mebendazole to be 15.0% and 17.6% and ERR 0–98.0% and 76.3%, respectively.”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [44]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Soil-transmitted helminth infections: ascariasis, trichuriasis, and hookworm
Bethony, J., Brooker, S., Albonico, M., Geiger, S. M., Loukas, A., Diemert, D., & Hotez, P. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68653-4 · Cited by 2,478
A simple device for quantitative stool thick-smear technique in Schistosomiasis mansoni.
Katz, N., Chaves, A. C., & Pellegrino, J. (1973) · PubMed · Cited by 2,414
Worldwide prevalence of anaemia 1993-2005: WHO global database on anaemia.
de Benoist, B., McLean, E., Egll, I., & Cogswell, M. E. (2008) · Cited by 1,543
A simple, device for quantita tive stool thick-smear technique in schistosomiasis mansoni
Katz, N., Chaves, A., & Pellegrino, J. (1972) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 1,338
Prevention and control of schistosomiasis and soil-transmitted helminthiasis.
(2002) · PubMed · Cited by 1,315
Drug resistance in veterinary helminths
Wolstenholme, A. J., Fairweather, I., Prichard, R., von Samson-Himmelstjerna, G., & Sangster, N. C. (2004) · Trends in Parasitology · doi:10.1016/j.pt.2004.07.010 · Cited by 813
Efficacy of Current Drugs Against Soil-Transmitted Helminth Infections
Keiser, J., & Utzinger, J. (2008) · JAMA · doi:10.1001/jama.299.16.1937 · Cited by 801
Self-citationHelminthiasis, S.-T. (2002) · World Health Organization eBooks · Cited by 781
Hotez, P. J., Bottazzi, M. E., Franco‐Paredes, C., Ault, S. K., & Periago, M. R. (2008) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0000300 · Cited by 730
Hookworm-Related Anaemia among Pregnant Women: A Systematic Review
Brooker, S., Hotez, P., & Bundy, D. A. (2008) · PLoS Neglected Tropical Diseases · doi:10.1371/journal.pntd.0000291 · Cited by 424
Flagged first, then by citations
Research works printed but not linked: 1
- 1995, Control of foodborne trematode infection: report of a WHO study group., WHO Tech Rep Ser, 891, 1
Cited by
Sorted by citations
Soil-transmitted helminth infections
Jourdan, P. M., Lamberton, P. H. L., Fenwick, A., & Addiss, D. G. (2017) · The Lancet · doi:10.1016/s0140-6736(17)31930-x · Cited by 1,069
Moser, W., Schindler, C., & Keiser, J. (2017) · BMJ · doi:10.1136/bmj.j4307 · Cited by 350
Self-citationLoukas, A. C., Hotez, P. J., Diemert, D. J., Yazdanbakhsh, M., McCarthy, J. S., Corrêa‐Oliveira, R., Croese, J., & Bethony, J. M. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.88 · Cited by 344
The contribution of mass drug administration to global health: past, present and future
Webster, J. P., Molyneux, D. H., Hotez, P. J., & Fenwick, A. (2014) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2013.0434 · Cited by 313
Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286
Metadata
- Authors
- Soukhathammavong, P. A., Sayasone, S., Phongluxa, K., Xayaseng, V., Utzinger, J., Vounatsou, P., Hatz, C., Akkhavong, K., Keiser, J., & Odermatt, P.
- Affiliations
- Swiss Tropical and Public Health Institute (CH)
- Ministry of Health (LA)
- Corresponding author
- Odermatt, Peter
- ORCID
- Venue
- PLoS Neglected Tropical Diseases
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-01-03
- Volume
- 6
- Issue
- 1
- Pages
- e1417
- ISSN
- 1935-2727 (ISSN-L)
- 1935-2735
- PMC
- PMC3250499
- OpenAlex
- W2016276858
- Cited by
- 147
- References
- 41
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 14 · 2023: 8 · 2022: 7 · 2021: 11 · 2020: 12 · 2019: 12 · 2018: 13 · 2017: 15 · 2016: 13 · 2015: 8 · 2014: 9 · 2013: 9 · 2012: 4
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS neglected tropical diseases (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- edoc (University of Basel) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, cc-by)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (114941, 110020)
- Direktion für Entwicklung und Zusammenarbeit
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Life Sciences › Immunology and Microbiology › Parasitology › Helminth infection and control
- Health Sciences › Medicine › Infectious Diseases › Parasitic Diseases Research and Treatment
- Keywords
- hookworm infection, albendazole, mebendazole, soil-transmitted helminths, Opisthorchis viverrini, opisthorchiasis, cure rate, egg reduction rate, school-aged children, preventive chemotherapy, Laos, adverse events, drug efficacy
- MeSH terms
- Animals, Anthelmintics, Child, Feces, Female, Hookworm Infections, Humans, Laos, Male, Mebendazole, Opisthorchiasis, Parasite Egg Count, Albendazole, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
