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Cited by 475

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Economic and Disease Burden of Dengue in Southeast Asia

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Shepard, Donald S., Undurraga, Eduardo A., Halasa, Yara A.·2013·PLoS Neglected Tropical Diseases
DOI 10.1371/journal.pntd.0002055
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Abstract

BACKGROUND: Dengue poses a substantial economic and disease burden in Southeast Asia (SEA). Quantifying this burden is critical to set policy priorities and disease-control strategies. METHODS AND FINDINGS: We estimated the economic and disease burden of dengue in 12 countries in SEA: Bhutan, Brunei, Cambodia, East-Timor, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, and Viet Nam. We obtained reported cases from multiple sources--surveillance data, World Health Organization (WHO), and published studies--and adjusted for underreporting using expansion factors from previous literature. We obtained unit costs per episode through a systematic literature review, and completed missing data using linear regressions. We excluded costs such as prevention and vector control, and long-term sequelae of dengue. Over the decade of 2001-2010, we obtained an annual average of 2.9 million (m) dengue episodes and 5,906 deaths. The annual economic burden (with 95% certainty levels) was US$950m (US$610m-US$1,384m) or about US$1.65 (US$1.06-US$2.41) per capita. The annual number of disability-adjusted life years (DALYs), based on the original 1994 definition, was 214,000 (120,000-299,000), which is equivalent to 372 (210-520) DALYs per million inhabitants. CONCLUSION: Dengue poses a substantial economic and disease burden in SEA with a DALY burden per million inhabitants in the region. This burden is higher than that of 17 other conditions, including Japanese encephalitis, upper respiratory infections, and hepatitis B.

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Metadata

Authors
Shepard, D. S., Undurraga, E. A., & Halasa, Y. A.
Venue
PLoS Neglected Tropical Diseases
Publisher
Public Library of Science (PLoS)
Published
2013-02-21
Volume
7
Issue
2
Pages
e2055
ISSN
  • 1935-2727 (ISSN-L)
  • 1935-2735
DOI
10.1371/journal.pntd.0002055
OpenAlex
W2024514465
Cited by
475
References
2
FWCI
35.92
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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CoChat. (2026). Citation check: Economic and Disease Burden of Dengue in Southeast Asia. https://app.cochat.ai/papers/10.1371/journal.pntd.0002055
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Shepard, D. S., Undurraga, E. A., & Halasa, Y. A. (2013). Economic and Disease Burden of Dengue in Southeast Asia. PLoS Neglected Tropical Diseases. https://doi.org/10.1371/journal.pntd.0002055

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