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DIFFERENCES IN DENGUE SEVERITY IN INFANTS, CHILDREN, AND ADULTS IN A 3-YEAR HOSPITAL-BASED STUDY IN NICARAGUA
Abstract
To investigate age-related differences in dengue severity, 114 infants, 1,211 children, and 346 adults with laboratory-confirmed dengue virus (DEN) infections presenting to three hospitals in major urban centers in Nicaragua were recruited from 1999 to 2001. The age distribution of dengue cases and the circulating serotype (predominantly DEN2) were representative of national data. Similar results were obtained when either dengue hemorrhagic fever/dengue shock syndrome or its principal manifestations (vascular permeability, internal hemorrhage, marked thrombocytopenia, and/or shock) were analyzed in relation to age and immune status. The burden of disease and of severe dengue was found predominantly in infants 4–9 months of age and in children 5–9 years old, and secondary DEN infection was a risk factor for severity in children. Age-related differences were identified in the prevalence of specific clinical manifestations as well as in their association with a confirmed DEN diagnosis. This represents one of the few comprehensive studies to analyze characteristics of dengue in infants, children, and adults in the same population and highlights age-related differences in dengue severity.
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Citations
Cited by
Global Spread and Persistence of Dengue
Kyle, J. L., & Harris, E. (2008) · Annual Review of Microbiology · doi:10.1146/annurev.micro.62.081307.163005 · Cited by 916
Self-citationSEROTYPE-SPECIFIC DIFFERENCES IN CLINICAL MANIFESTATIONS OF DENGUE
BALMASEDA, A., HAMMOND, S. N., PÉREZ, L., TELLEZ, Y., SABORÍO, S. I., MERCADO, J. C., CUADRA, R., ROCHA, J., PÉREZ, M. A., SILVA, S., et al. (2006) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2006.74.449 · Cited by 299
Self-citationWhitehorn, J., & Simmons, C. P. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.07.022 · Cited by 282
Convergent Antibody Signatures in Human Dengue
Parameswaran, P., Liu, Y., Roskin, K. M., Jackson, K. K. L., Dixit, V. P., Lee, J.-Y., Artiles, K. L., Zompi, S., Vargas, M. J., Simen, B. B., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.05.008 · Cited by 261
Self-citationSpatial and temporal patterns of dengue infections in Timor-Leste, 2005–2013
Wangdi, K., Clements, A. C. A., Du, T., & Nery, S. V. (2018) · Parasites & Vectors · doi:10.1186/s13071-017-2588-4 · Cited by 70
Metadata
- Authors
- HAMMOND, S. N., BALMASEDA, A., PÉREZ, L., TELLEZ, Y., SABORÍO, S. I., MERCADO, J. C., VIDEA, E., RODRIGUEZ, Y., PÉREZ, M. A., CUADRA, R., SOLANO, S., ROCHA, J., IDIAQUEZ, W., GONZALEZ, A., & HARRIS, E.
- Venue
- The American Journal of Tropical Medicine and Hygiene
- Published
- 2005-12
- Volume
- 73
- Issue
- 6
- Pages
- 1063-1070
- ISSN
- 0002-9637 (ISSN-L)
- OpenAlex
- W2143340783
- Cited by
- 358
- References
- 0
- FWCI
- 9.70
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: DIFFERENCES IN DENGUE SEVERITY IN INFANTS, CHILDREN, AND ADULTS IN A 3-YEAR HOSPITAL-BASED STUDY IN NICARAGUA. https://app.cochat.ai/papers/10.4269/ajtmh.2005.73.1063
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- HAMMOND, S. N., BALMASEDA, A., PÉREZ, L., TELLEZ, Y., SABORÍO, S. I., MERCADO, J. C., VIDEA, E., RODRIGUEZ, Y., PÉREZ, M. A., CUADRA, R., SOLANO, S., ROCHA, J., IDIAQUEZ, W., GONZALEZ, A., & HARRIS, E. (2005). DIFFERENCES IN DENGUE SEVERITY IN INFANTS, CHILDREN, AND ADULTS IN A 3-YEAR HOSPITAL-BASED STUDY IN NICARAGUA. The American Journal of Tropical Medicine and Hygiene. https://doi.org/10.4269/ajtmh.2005.73.1063
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
