The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Short-Term Exposure of Multipotent Stromal Cells to Low Oxygen Increases Their Expression of CX3CR1 and CXCR4 and Their Engraftment In Vivo
Open accessAbstract
The ability of stem/progenitor cells to migrate and engraft into host tissues is key to their potential use in gene and cell therapy. Among the cells of interest are the adherent cells from bone marrow, referred to as mesenchymal stem cells or multipotent stromal cells (MSC). Since the bone marrow environment is hypoxic, with oxygen tensions ranging from 1% to 7%, we decided to test whether hypoxia can upregulate chemokine receptors and enhance the ability of human MSCs to engraft in vivo. Short-term exposure of MSCs to 1% oxygen increased expression of the chemokine receptors CX3CR1and CXCR4, both as mRNA and as protein. After 1-day exposure to low oxygen, MSCs increased in vitro migration in response to the fractalkine and SDF-1alpha in a dose dependent manner. Blocking antibodies for the chemokine receptors significantly decreased the migration. Xenotypic grafting into early chick embryos demonstrated cells from hypoxic cultures engrafted more efficiently than cells from normoxic cultures and generated a variety of cell types in host tissues. The results suggest that short-term culture of MSCs under hypoxic conditions may provide a general method of enhancing their engraftment in vivo into a variety of tissues.
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1 retracted
RETRACTED ARTICLE: Pluripotency of mesenchymal stem cells derived from adult marrow
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Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
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Self-citationChemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL
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Cited by
Vallabhaneni, K. C., Penfornis, P., Dhule, S., Guillonneau, F., Adams, K. V., Mo, Y. Y., Xu, R., Liu, Y., Watabe, K., Vemuri, M. C., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3211 · Cited by 332
Self-citationStem Cells and Cell Therapies in Lung Biology and Lung Diseases
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Fang, X., Neyrinck, A. P., Matthay, M. A., & Lee, J. W. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.119917 · Cited by 258
Choi, J. R., Pingguan-Murphy, B., Wan Abas, W. A. B., Yong, K. W., Poon, C. T., Noor Azmi, M. A., Omar, S. Z., Chua, K. H., Xu, F., & Wan Safwani, W. K. Z. (2015) · PLOS ONE · doi:10.1371/journal.pone.0115034 · Cited by 63
Metadata
- Authors
- Hung, S.-C., Pochampally, R. R., Hsu, S.-C., Sanchez, C., Chen, S.-C., Spees, J., & Prockop, D. J.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-05-02
- Volume
- 2
- Issue
- 5
- Pages
- e416
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2011904570
- Cited by
- 317
- References
- 31
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Short-Term Exposure of Multipotent Stromal Cells to Low Oxygen Increases Their Expression of CX3CR1 and CXCR4 and Their Engraftment In Vivo. https://app.cochat.ai/papers/10.1371/journal.pone.0000416
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- Hung, S.-C., Pochampally, R. R., Hsu, S.-C., Sanchez, C., Chen, S.-C., Spees, J., & Prockop, D. J. (2007). Short-Term Exposure of Multipotent Stromal Cells to Low Oxygen Increases Their Expression of CX3CR1 and CXCR4 and Their Engraftment In Vivo. PLoS ONE. https://doi.org/10.1371/journal.pone.0000416
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
