The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Resistance Exercise Reverses Aging in Human Skeletal Muscle
Open accessAbstract
Human aging is associated with skeletal muscle atrophy and functional impairment (sarcopenia). Multiple lines of evidence suggest that mitochondrial dysfunction is a major contributor to sarcopenia. We evaluated whether healthy aging was associated with a transcriptional profile reflecting mitochondrial impairment and whether resistance exercise could reverse this signature to that approximating a younger physiological age. Skeletal muscle biopsies from healthy older (N = 25) and younger (N = 26) adult men and women were compared using gene expression profiling, and a subset of these were related to measurements of muscle strength. 14 of the older adults had muscle samples taken before and after a six-month resistance exercise-training program. Before exercise training, older adults were 59% weaker than younger, but after six months of training in older adults, strength improved significantly (P<0.001) such that they were only 38% lower than young adults. As a consequence of age, we found 596 genes differentially expressed using a false discovery rate cut-off of 5%. Prior to the exercise training, the transcriptome profile showed a dramatic enrichment of genes associated with mitochondrial function with age. However, following exercise training the transcriptional signature of aging was markedly reversed back to that of younger levels for most genes that were affected by both age and exercise. We conclude that healthy older adults show evidence of mitochondrial impairment and muscle weakness, but that this can be partially reversed at the phenotypic level, and substantially reversed at the transcriptome level, following six months of resistance exercise training.
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Citations
Cites
Exercise training and nutritional supplementation for physical frailty in very elderly people
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“Although the strength and functional benefits of resistance exercise training are well known[24,30,31], it is unclear whether training alters the age-associated alterations in the transcriptome profile of healthy older adults.”
BackgroundGene expression profile of aging and its retardation by caloric restriction
Lee, C.-K., Klopp, R. G., Weindruch, R., & Prolla, T. A. (1999) · Science · doi:10.1126/science.285.5432.1390 · Cited by 1,473
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Transcriptional profiling of aging in human muscle reveals a common aging signature
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Cited by
Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives
Rolland, Y., Czerwinski, S., van Kan, G. A., Morley, J. E., Cesari, M., Onder, G., Woo, J., Baumgartner, R., Pillard, F., Boirie, Y., et al. (2008) · The Journal of nutrition, health and aging · doi:10.1007/bf02982704 · Cited by 1,071
Mitochondrial fragmentation in neurodegeneration.
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Resistance Training is Medicine: Effects of Strength Training on Health
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Oxidative Stress, Molecular Inflammation and Sarcopenia
Meng, S.-J., & Yu, L.-J. (2010) · International Journal of Molecular Sciences · doi:10.3390/ijms11041509 · Cited by 637
“In fact, resistance training can increase the activity of mitochondrial enzymes [92], and decreases skeletal muscle TNF-α in frail elderly humans [85].”
BackgroundMitochondrial fission and remodelling contributes to muscle atrophy
Romanello, V., Guadagnin, E., Gomes, L., Roder, I., Sandri, C., Petersen, Y., Milan, G., Masiero, E., Del Piccolo, P., Foretz, M., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.60 · Cited by 596
Metadata
- Authors
- Melov, S., Tarnopolsky, M. A., Beckman, K., Felkey, K., & Hubbard, A.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2007-05-23
- Volume
- 2
- Issue
- 5
- Pages
- e465
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2061924523
- Cited by
- 347
- References
- 14
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- gold
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