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Cited by 347

The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.

Resistance Exercise Reverses Aging in Human Skeletal Muscle

Open access
Melov, Simon, Tarnopolsky, Mark A., Beckman, Kenneth, Felkey, Krysta, Hubbard, Alan·2007·PLoS ONE
DOI 10.1371/journal.pone.0000465
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Abstract

Human aging is associated with skeletal muscle atrophy and functional impairment (sarcopenia). Multiple lines of evidence suggest that mitochondrial dysfunction is a major contributor to sarcopenia. We evaluated whether healthy aging was associated with a transcriptional profile reflecting mitochondrial impairment and whether resistance exercise could reverse this signature to that approximating a younger physiological age. Skeletal muscle biopsies from healthy older (N = 25) and younger (N = 26) adult men and women were compared using gene expression profiling, and a subset of these were related to measurements of muscle strength. 14 of the older adults had muscle samples taken before and after a six-month resistance exercise-training program. Before exercise training, older adults were 59% weaker than younger, but after six months of training in older adults, strength improved significantly (P<0.001) such that they were only 38% lower than young adults. As a consequence of age, we found 596 genes differentially expressed using a false discovery rate cut-off of 5%. Prior to the exercise training, the transcriptome profile showed a dramatic enrichment of genes associated with mitochondrial function with age. However, following exercise training the transcriptional signature of aging was markedly reversed back to that of younger levels for most genes that were affected by both age and exercise. We conclude that healthy older adults show evidence of mitochondrial impairment and muscle weakness, but that this can be partially reversed at the phenotypic level, and substantially reversed at the transcriptome level, following six months of resistance exercise training.

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Metadata

Authors
Melov, S., Tarnopolsky, M. A., Beckman, K., Felkey, K., & Hubbard, A.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2007-05-23
Volume
2
Issue
5
Pages
e465
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0000465
OpenAlex
W2061924523
Cited by
347
References
14
FWCI
6.70
Type
journal article
Language
en
Open access
gold

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