The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Pancreatic Insulin Content Regulation by the Estrogen Receptor ERα
Open accessAbstract
The function of pancreatic beta-cells is the synthesis and release of insulin, the main hormone involved in blood glucose homeostasis. Estrogen receptors, ER alpha and ER beta, are important molecules involved in glucose metabolism, yet their role in pancreatic beta-cell physiology is still greatly unknown. In this report we show that both ER alpha and ER beta are present in pancreatic beta-cells. Long term exposure to physiological concentrations of 17beta-estradiol (E2) increased beta-cell insulin content, insulin gene expression and insulin release, yet pancreatic beta-cell mass was unaltered. The up-regulation of pancreatic beta-cell insulin content was imitated by environmentally relevant doses of the widespread endocrine disruptor Bisphenol-A (BPA). The use of ER alpha and ER beta agonists as well as ER alphaKO and ER betaKO mice suggests that the estrogen receptor involved is ER alpha. The up-regulation of pancreatic insulin content by ER alpha activation involves ERK1/2. These data may be important to explain the actions of E2 and environmental estrogens in endocrine pancreatic function and blood glucose homeostasis.
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Cites
In vitro molecular mechanisms of bisphenol A action.
Wetherill, Y. B., Akingbemi, B. T., Kanno, J., McLachlan, J. A., Nadal, A., Sonnenschein, C., Watson, C. S., Zoeller, R. T., & Belcher, S. M. (2007) · Reproductive Toxicology · doi:10.1016/j.reprotox.2007.05.010 · Cited by 920
International Union of Pharmacology. LXIV. Estrogen Receptors
Dahlman-Wright, K., Cavailles, V., Fuqua, S. A., Jordan, V. C., Katzenellenbogen, J. A., Korach, K. S., Maggi, A., Muramatsu, M., Parker, M. G., & Gustafsson, J.-Å. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.8 · Cited by 583
Bryzgalova, G., Gao, H., Ahren, B., Zierath, J. R., Galuska, D., Steiler, T. L., Dahlman-Wright, K., Nilsson, S., Gustafsson, J.-Å., Efendic, S., et al. (2006) · Diabetologia · doi:10.1007/s00125-005-0105-3 · Cited by 384
Muscle GLUT4 regulation by estrogen receptors ERβ and ERα
Barros, R. P. A., Machado, U. F., Warner, M., & Gustafsson, J.-Å. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510391103 · Cited by 263
Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic β cells
Khoo, S., Griffen, S. C., Xia, Y., Baer, R. J., German, M. S., & Cobb, M. H. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301198200 · Cited by 163
Cited by
EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals
Gore, A. C., Chappell, V. A., Fenton, S. E., Flaws, J. A., Nadal, A., Prins, G. S., Toppari, J., & Zoeller, R. T. (2015) · Endocrine Reviews · doi:10.1210/er.2015-1010 · Cited by 2,407
Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus
Kautzky-Willer, A., Harreiter, J., & Pacini, G. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1137 · Cited by 2,043
Rochester, J. R., & Bolden, A. L. (2015) · Environmental Health Perspectives · doi:10.1289/ehp.1408989 · Cited by 1,524
State-of-the-science of endocrine disrupting chemicals, 2012
Bergman, Å., Heindel, J., Jobling, S., Kidd, K., & Zoeller, R. T. (2012) · Toxicology Letters · doi:10.1016/j.toxlet.2012.03.020 · Cited by 1,388
The role of estrogens in control of energy balance and glucose homeostasis
Mauvais-Jarvis, F., Clegg, D. J., & Hevener, A. L. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1055 · Cited by 1,329
Metadata
- Authors
- Alonso-Magdalena, P., Ropero, A. B., Carrera, M. P., Cederroth, C. R., Baquié, M., Gauthier, B. R., Nef, S., Stefani, E., & Nadal, A.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-04-30
- Volume
- 3
- Issue
- 4
- Pages
- e2069
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W1996857104
- Cited by
- 395
- References
- 5
- FWCI
- 23.27
- Type
- journal article
- Language
- en
- Open access
- gold
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- Alonso-Magdalena, P., Ropero, A. B., Carrera, M. P., Cederroth, C. R., Baquié, M., Gauthier, B. R., Nef, S., Stefani, E., & Nadal, A. (2008). Pancreatic Insulin Content Regulation by the Estrogen Receptor ERα. PLoS ONE. https://doi.org/10.1371/journal.pone.0002069
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
