The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
Mitochondrial DNA Polymorphism A4917G Is Independently Associated with Age-Related Macular Degeneration
Open accessAbstract
The objective of this study was to determine if MTND2*LHON4917G (4917G), a specific non-synonymous polymorphism in the mitochondrial genome previously associated with neurodegenerative phenotypes, is associated with increased risk for age-related macular degeneration (AMD). A preliminary study of 393 individuals (293 cases and 100 controls) ascertained at Vanderbilt revealed an increased occurrence of 4917G in cases compared to controls (15.4% vs.9.0%, p = 0.11). Since there was a significant age difference between cases and controls in this initial analysis, we extended the study by selecting Caucasian pairs matched at the exact age at examination. From the 1547 individuals in the Vanderbilt/Duke AMD population association study (including 157 in the preliminary study), we were able to match 560 (280 cases and 280 unaffected) on exact age at examination. This study population was genotyped for 4917G plus specific AMD-associated nuclear genome polymorphisms in CFH, LOC387715 and ApoE. Following adjustment for the listed nuclear genome polymorphisms, 4917G independently predicts the presence of AMD (OR = 2.16, 95%CI 1.20-3.91, p = 0.01). In conclusion, a specific mitochondrial polymorphism previously implicated in other neurodegenerative phenotypes (4917G) appears to convey risk for AMD independent of recently discovered nuclear DNA polymorphisms.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Consistent with the role of mitochondria in neurodegenerative disease, a specific mitochondrial DNA polymorphism, A4917G, is reported to be associated with AMD (20).”
From Unraveling a Multifactorial Late-Onset Disease: From Genetic Susceptibility to Disease Mechanisms for Age-Related Macular Degeneration (2009) · cites this paper as [20]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Sequence and organization of the human mitochondrial genome
Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H. L., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., et al. (1981) · Nature · doi:10.1038/290457a0 · Cited by 9,740
Mitochondrial diseases in man and mouse
Wallace, D. C. (1999) · Science · doi:10.1126/science.283.5407.1482 · Cited by 3,060
Complement factor H variant increases the risk of age-related macular degeneration
Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424
Self-citationThe Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration
Beatty, S., Koh, H.-H., Phil, M., Henson, D., & Boulton, M. (2000) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00140-5 · Cited by 2,051
Mitochondrial Respiratory-Chain Diseases
DiMauro, S., & Schon, E. A. (2003) · New England Journal of Medicine · doi:10.1056/nejmra022567 · Cited by 1,672
Classification of European mtDNAs From an Analysis of Three European Populations
Torroni, A., Huoponen, K., Francalacci, P., Petrozzi, M., Morelli, L., Scozzari, R., Obinu, D. A., Savontaus, M., & Wallace, D. C. (1996) · Genetics · doi:10.1093/genetics/144.4.1835 · Cited by 838
Mitochondrial Polymorphisms Significantly Reduce the Risk of Parkinson Disease
van der Walt, J. M., Nicodemus, K. K., Martin, E. R., Scott, W. K., NANCE, M. A., Watts, R. L., Hubble, J. P., Haines, J. L., Koller, W. C., Lyons, K. E., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/373937 · Cited by 537
Self-citationMitochondrial DNA sequence variation in human evolution and disease.
Wallace, D. C. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8739 · Cited by 525
Human mtDNA Haplogroups Associated with High or Reduced Spermatozoa Motility
Ruiz‐Pesini, E., Lapeña, A. C., Díez‐Sánchez, C., Martos, A. P., Montoya, J., Alvarez, E., Díaz, M. Á., Urriés, A., Montoro, L., López-Pérez, M. J., et al. (2000) · The American Journal of Human Genetics · doi:10.1086/303040 · Cited by 504
Mitochondrial DNA variation in human evolution and disease
Wallace, D. C., Brown, M. D., & Lott, M. T. (1999) · Gene · doi:10.1016/s0378-1119(99)00295-4 · Cited by 467
Cited by
Sorted by citations
Age-related macular degeneration
Fleckenstein, M., Keenan, T. D. L., Guymer, R. H., Chakravarthy, U., Schmitz-Valckenberg, S., Klaver, C. C. W., Wong, W. T., & Chew, E. Y. (2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00265-2 · Cited by 1,093
The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD
Datta, S., Cano, M., Ebrahimi, K. B., Wang, L., & Handa, J. T. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.03.002 · Cited by 843
Age-Related Macular Degeneration: Genetics and Biology Coming Together
Fritsche, L. G., Fariss, R. N., Stambolian, D. E., Abecasis, G. R., Curcio, C. A., & Swaroop, A. (2014) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-090413-025610 · Cited by 546
Mechanisms of mitochondrial dysfunction and their impact on age-related macular degeneration
Kaarniranta, K., Uusitalo, H. M. T., Błasiak, J., Felszeghy, S., Kannan, R., Kauppinen, A., Salminen, A., Sinha, D., & Ferrington, D. A. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100858 · Cited by 548
Doyle, S., Campbell, M., Ozaki, E., Salomon, R. G., Mori, A., Kenna, P. F., Farrar, G. J., Kiang, A., Humphries, M. M., Lavelle, E. C., et al. (2012) · Nature Medicine · doi:10.1038/nm.2717 · Cited by 428
Zhao, C., Yasumura, D., Li, X., Matthes, M., Lloyd, M., Nielsen, G., Ahern, K., Snyder, M., Bok, D., Dunaief, J. L., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci44303 · Cited by 303
Curcio, C. A., Johnson, M., Huang, J.-D., & Rudolf, M. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.08.001 · Cited by 293
Handa, J. T., Rickman, C. B., Dick, A. D., Gorin, M. B., Miller, J. W., Toth, C. A., Ueffing, M., Zarbin, M. A., & Farrer, L. A. (2019) · Nature Communications · doi:10.1038/s41467-019-11262-1 · Cited by 285
Swaroop, A., Chew, E. Y., Bowes Rickman, C., & Abecasis, G. R. (2009) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.9.081307.164350 · Cited by 270
Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration
Curcio, C. A., Johnson, M., Huang, J.-D., & Rudolf, M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r002238 · Cited by 203
Kaarniranta, K., Pawłowska, E., Szczepańska, J., Jabłkowska, A., & Błasiak, J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102374 · Cited by 193
Cano, M., Thimmalappula, R., Fujihara, M., Nagai, N., Sporn, M. B., Wang, A. L., Neufeld, A. H., Biswal, S. S., & Handa, J. T. (2009) · Vision Research · doi:10.1016/j.visres.2009.08.018 · Cited by 188
Age-Related Macular Degeneration: Role of Oxidative Stress and Blood Vessels
Ruan, Y., Jiang, S., & Gericke, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031296 · Cited by 198
How does the macula protect itself from oxidative stress?
Handa, J. T. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.03.006 · Cited by 154
McKay, G. J., Patterson, C. C., Chakravarthy, U., Dasari, S., Klaver, C. C., Vingerling, J. R., Ho, L., de Jong, P. T. V. M., Fletcher, A. E., Young, I. S., et al. (2011) · Human Mutation · doi:10.1002/humu.21577 · Cited by 151
Fujihara, M., Nagai, N., Sussan, T. E., Biswal, S. S., & Handa, J. T. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003119 · Cited by 150
Mitochondrial DNA Haplogroups Associated with Age-Related Macular Degeneration
Udar, N., Atilano, S. R., Memarzadeh, M., Boyer, D. S., Chwa, M., Lu, S. Y., Maguen, B., Langberg, J., Coskun, P. E., Wallace, D. C., et al. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2646 · Cited by 133
Fletcher, A. (2010) · Ophthalmic Research · doi:10.1159/000316476 · Cited by 129
Kenney, M. C., Chwa, M., Atilano, S. R., Falatoonzadeh, P., Ramírez, C., Malik, D., Tarek, M., Cáceres‐del‐Carpio, J., Nesburn, A. B., Boyer, D. S., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu065 · Cited by 112
Gorin, M. B. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.04.004 · Cited by 105
Lipids, Lipoproteins, and Age-Related Macular Degeneration
Ebrahimi, K. B., & Handa, J. T. (2011) · Journal of Lipids · doi:10.1155/2011/802059 · Cited by 107
Cano, M., Wang, L., Wan, J., Barnett, B. P., Ebrahimi, K. B., Qian, J. X., & Handa, J. T. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.01.004 · Cited by 102
SanGiovanni, J. P., Arking, D. E., Iyengar, S. K., Elashoff, M. R., Clemons, T. E., Reed, G. F., Henning, A. K., Sivakumaran, T. A., Xu, X., DeWan, A. T., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005508 · Cited by 102
Wang, A. L., Lukas, T. J., Yuan, M., Du, N. Y., Handa, J. T., & Neufeld, A. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005304 · Cited by 98
Kenney, M. C., Chwa, M., Atilano, S. R., Pavlis, J. M., Falatoonzadeh, P., Ramírez, C., Malik, D., Hsu, T., Woo, G., Soe, K., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054339 · Cited by 97
Gene–environment interactions in ocular diseases
Saccà, S. C., Bolognesi, C., Battistella, A., Bagnis, A., & Izzotti, A. (2008) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2008.11.002 · Cited by 84
Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatment
Mehrzadi, S., Hemati, K., Reiter, R. J., & Hosseinzadeh, A. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1737015 · Cited by 82
Mito-nuclear co-evolution: the positive and negative sides of functional ancient mutations
Levin, L., Blumberg, A., Barshad, G., & Mishmar, D. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00448 · Cited by 86
Levin, L., Zhidkov, I., Gurman, Y., Hawlena, H., & Mishmar, D. (2013) · Genome Biology and Evolution · doi:10.1093/gbe/evt058 · Cited by 73
Liu, M. M., Chan, C., & Tuo, J. (2012) · Human Genomics · doi:10.1186/1479-7364-6-13 · Cited by 70
Age-Related Macular Degeneration: Clinical Findings, Histopathology and Imaging Techniques
Zarbin, M. A., Casaroli-Marano, R. P., & Rosenfeld, P. J. (2014) · Developments in ophthalmology · doi:10.1159/000358536 · Cited by 66
Maurya, M., Bora, K., Blomfield, A. K., Pavlovich, M. C., Huang, S., Liu, C.-H., & Chen, J. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.369098 · Cited by 63
Mueller, E. E., Schaier, E., Brunner, S. M., Eder, W., Mayr, J. A., Egger, S. F., Nischler, C., Oberkofler, H., Reitsamer, H. A., Patsch, W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030874 · Cited by 62
Kopplin, L. J., Igo, R. P., Wang, Y., Sivakumaran, T. A., Hagstrom, S. A., Peachey, N. S., Francis, P. J., Klein, M. L., SanGiovanni, J. P., Chew, E. Y., et al. (2010) · Genes and Immunity · doi:10.1038/gene.2010.39 · Cited by 62
Functional Differences between Mitochondrial Haplogroup T and Haplogroup H in HEK293 Cybrid Cells
Mueller, E. E., Brunner, S. M., Mayr, J. A., Stanger, O., Sperl, W., & Kofler, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052367 · Cited by 61
Jabbehdari, S., & Handa, J. T. (2020) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2020.09.002 · Cited by 61
Atilano, S. R., Malik, D., Chwa, M., Cáceres‐del‐Carpio, J., Nesburn, A. B., Boyer, D. S., Kuppermann, B. D., Jazwinski, S. M., Miceli, M. V., Wallace, D. C., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv173 · Cited by 60
Oxidative stress in dry age-related macular degeneration and exfoliation syndrome
Chiras, D., Kitsos, G., Petersen, M. B., Skalidakis, I., & Κroupis, C. (2014) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2014.968703 · Cited by 56
Kenney, M. C., Atilano, S. R., Boyer, D. S., Chwa, M., Chak, G., Chinichian, S., Coskun, P. E., Wallace, D. C., Nesburn, A. B., & Udar, N. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4778 · Cited by 55
Kenney, M. C., Hertzog, D., Chak, G., Atilano, S. R., Khatibi, N. H., Soe, K., Nobe, A., Yang, E., Chwa, M., Zhu, F., et al. (2013) · BMC Medical Genetics · doi:10.1186/1471-2350-14-4 · Cited by 56
Age-related macular degeneration: genetic and clinical findings
Kokotas, H., Grigoriadou, M., & Petersen, M. B. (2010) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2011.091 · Cited by 55
Pfister, G., & Savino, W. (2008) · NeuroImmunoModulation · doi:10.1159/000156477 · Cited by 44
The Pathophysiology of Cigarette Smoking and Age-Related Macular Degeneration
Dhubhghaill, S. N., Cahill, M. T., Campbell, M., Cassidy, L., Humphries, M. M., & Humphries, P. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-1399-9_50 · Cited by 42
Fritsche, L. G., Freitag‐Wolf, S., Bettecken, T., Meitinger, T., Keilhauer, C. N., Krawczak, M., & Weber, B. H. F. (2008) · Human Mutation · doi:10.1002/humu.20957 · Cited by 43
Evaluating Mitochondrial DNA Variation in Autism Spectrum Disorders
Hadjixenofontos, A., Schmidt, M. A., Whitehead, P. L., Konidari, I., Hedges, D. J., Wright, H. H., Abramson, R. K., Menon, R., Williams, S. M., Cuccaro, M. L., et al. (2012) · Annals of Human Genetics · doi:10.1111/j.1469-1809.2012.00736.x · Cited by 44
Self-citationTuuminen, R., Uusitalo‐Järvinen, H., Aaltonen, V., Hautala, N. M., Kaipiainen, S., Laitamäki, N., Ollila, M., Rantanen, J., Välimäki, S., Sipilä, R., et al. (2017) · Acta Ophthalmologica · doi:10.1111/aos.13501 · Cited by 45
Unravelling the genetic basis of renal diseases; from single gene to multifactorial disorders
McKnight, A. J., Currie, D., & Maxwell, A. P. (2009) · The Journal of Pathology · doi:10.1002/path.2639 · Cited by 38
Malik, D., Hsu, T., Falatoonzadeh, P., Cáceres‐del‐Carpio, J., Tarek, M., Chwa, M., Atilano, S. R., Ramírez, C., Nesburn, A. B., Boyer, D. S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099003 · Cited by 36
The Application of Genetic Risk Scores in Age-Related Macular Degeneration: A Review
Bailey, J. N. C., Hoffman, J., Sardell, R. J., Scott, W. K., Pericak‐Vance, M. A., & Haines, J. L. (2016) · Journal of Clinical Medicine · doi:10.3390/jcm5030031 · Cited by 36
Self-citationMitochondrial Haplogroup X is associated with successful aging in the Amish
Courtenay, M. D., Gilbert, J. R., Jiang, L., Cummings, A. C., Gallins, P. J., Caywood, L. J., Reinhart‐Mercer, L., Fuzzell, D., Knebusch, C., Laux, R. A., et al. (2011) · Human Genetics · doi:10.1007/s00439-011-1060-3 · Cited by 30
Self-citationMcKay, G. J., Dasari, S., Patterson, C., Chakravarthy, U., & Silvestri, G. (2010) · PubMed Central · Cited by 29
The role of mitochondria in AMD: Current knowledge and future applications
Kenney, M. C., Riazi-Esfahani, M., & Kuppermann, B. (2017) · Journal of Ophthalmic and Vision Research · doi:10.4103/jovr.jovr_182_17 · Cited by 29
A genetic approach to stratification of risk for age-related macular degeneration
Zanke, B. W., Hawken, S., Carter, R., & Chow, D. R. (2010) · Canadian Journal of Ophthalmology · doi:10.3129/i09-209 · Cited by 27
Persad, P. J., Heid, I. M., Weeks, D. E., Baird, P. N., de Jong, E. K., Haines, J. L., Pericak‐Vance, M. A., & Scott, W. K. (2017) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-21734 · Cited by 28
Self-citationBringing age-related macular degeneration into focus
Allikmets, R., & Dean, M. (2008) · Nature Genetics · doi:10.1038/ng0708-820 · Cited by 26
Macchioni, L., Chiasserini, D., Mezzasoma, L., Davidescu, M., Orvietani, P. L., Fettucciari, K., Salviati, L., Cellini, B., & Bellezza, I. (2020) · Antioxidants · doi:10.3390/antiox10010025 · Cited by 26
Cano, M., Callaway, N. F., Kondo, N., Dike, S., & Handa, J. T. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.04.010 · Cited by 25
Highly Variable Disease Courses in Siblings with Stargardt Disease
Valkenburg, D., Runhart, E. H., Bax, N. M., Liefers, B. J., Lambertus, S., Sánchez, C. I., Cremers, F. P. M., & Hoyng, C. B. (2019) · Ophthalmology · doi:10.1016/j.ophtha.2019.07.010 · Cited by 21
Moschos, M. M., Nitoda, E., Chatziralli, I., & Demopoulos, C. A. (2014) · Journal of Chemistry · doi:10.1155/2014/317536 · Cited by 19
Nadeem, U., Xie, B., Xie, E. F., D’Souza, M., Dao, D., Sulakhe, D., & Skondra, D. (2022) · Translational Vision Science & Technology · doi:10.1167/tvst.11.8.10 · Cited by 18
Retinal Microenvironment Imbalance in Dry Age-Related Macular Degeneration: A Mini-Review
Barnett, B. P., & Handa, J. T. (2013) · Gerontology · doi:10.1159/000346169 · Cited by 19
Mitochondria: The Retina’s Achilles’ Heel in AMD
Ferrington, D. A., Kenney, M. C., Atilano, S. R., Hurley, J. B., Brown, E. E., & Ash, J. D. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-66014-7_10 · Cited by 18
MITOCHONDRIAL VARIATION AND THE RISK OF AGE-RELATED MACULAR DEGENERATION ACROSS DIVERSE POPULATIONS
RESTREPO, N. A., Mitchell, S. L., Goodloe, R., Murdock, D. G., Haines, J. L., & Crawford, D. C. (2014) · Pacific Symposium on Biocomputing (PSB) · doi:10.1142/9789814644730_0024 · Cited by 18
Self-citationEvolution and disease converge in the mitochondrion
Mishmar, D., & Zhidkov, I. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.003 · Cited by 18
AMD Genomics: Non-Coding RNAs as Biomarkers and Therapeutic Targets
Zhang, C., Owen, L. A., Lillvis, J. H., Zhang, S. X., Kim, I. K., & DeAngelis, M. M. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11061484 · Cited by 19
Humphries, M. M., Kenna, P. F., Campbell, M., Tam, L. C. S., Nguyen, A. T. H., Farrar, G. J., Botto, M., Kiang, A. S., & Humphries, P. (2011) · European Journal of Human Genetics · doi:10.1038/ejhg.2011.151 · Cited by 15
Koller, A., Lamina, C., Brandl, C., Zimmermann, M. E., Stark, K. J., Weißensteiner, H., Würzner, R., Heid, I. M., & Kronenberg, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216406 · Cited by 14
Atilano, S. R., Udar, N., Satalich, T. A., Udar, V., Chwa, M., & Kenney, M. C. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246114 · Cited by 14
Gorin, M. B., & daSilva, M. J. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.107894 · Cited by 14
Guo, H., Li, J., & Lu, P. (2023) · BMC Ophthalmology · doi:10.1186/s12886-023-03237-0 · Cited by 13
Ulcerative Colitis Is Under Dual (Mitochondrial and Nuclear) Genetic Control
Rosa, A., Abrantes, P., Sousa, I., Francisco, V., Santos, P., Francisco, D., Xavier, J. M., & Oliveira, S. A. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000694 · Cited by 13
Thaker, K., Chwa, M., Atilano, S. R., Coskun, P. E., Cáceres‐del‐Carpio, J., Udar, N., Boyer, D. S., Jazwinski, S. M., Miceli, M. V., Nesburn, A. B., et al. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.04.005 · Cited by 12
Rezvani, Z., Didari, E., Arastehkani, A., Kalahroudi, V. G., Aryani, O., Kamalıdehghan, B., & Houshmand, M. (2013) · Molecular Biology Reports · doi:10.1007/s11033-013-2801-2 · Cited by 12
Jiang, Y., Liang, G., Wang, L., Jiang, J., Du, G., & Huang, Y. (2013) · Journal of International Medical Research · doi:10.1177/0300060513475570 · Cited by 11
A Genetic View of the Mitochondrial Role in Ageing: Killing Us Softly
Levin, L., & Mishmar, D. (2015) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-2404-2_4 · Cited by 11
Genetic Risk Evaluation in Wet Age-Related Macular Degeneration Treatment Response
Chaudhary, V., Brent, M., Lam, W.-C., Devenyi, R., Teichman, J., Mak, M., Barbosa, J., Kaur, H., Carter, R., & Farrokhyar, F. (2016) · Ophthalmologica · doi:10.1159/000446819 · Cited by 10
Anand, A., Sharma, K., Chen, W., & Sharma, N. (2014) · Current Genomics · doi:10.2174/1389202915666140516204512 · Cited by 10
Chen, M., Wang, Y., Dalal, R., Du, J., & Vollrath, D. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2402384121 · Cited by 9
Tilleul, J., Richard, F., Puche, N., Zerbib, J., Leveziel, N., Sahel, J., Cohen, S. Y., Korobelnik, J., Feingold, J., Münnich, A., et al. (2013) · Europe PMC (PubMed Central) · Cited by 8
Nicholson, C., Ishii, M., Annamalai, B., Chandler, K., Chwa, M., Kenney, M. C., Shah, N., & Rohrer, B. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129798 · Cited by 8
Mitochondrial DNA Pathogenic Variants in Ophthalmic Diseases: A Review
Abu‐Amero, K. K., Almadani, B., Abualkhair, S., Hameed, S., Kondkar, A. A., Sollazzo, A., Yu, A. C., Busin, M., & Zauli, G. (2025) · Genes · doi:10.3390/genes16030347 · Cited by 7
PPAR Nuclear Receptors and Altered RPE Lipid Metabolism in Age-Related Macular Degeneration
Malek, G., Hu, P., Wielgus, A. R., Dwyer, M. A., & Cousins, S. W. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-1399-9_49 · Cited by 7
Alwehaidah, M. S., Bakhiet, M., & AlFadhli, S. M. (2020) · Medical Principles and Practice · doi:10.1159/000509937 · Cited by 6
Mitochondrial DNA Changes in Respiratory Complex I Genes in Brain Gliomas
Kozakiewicz, P., Grzybowska‐Szatkowska, L., Ciesielka, M., Całka, P., Osuchowski, J., Szmygin, P., Jarosz, B., Ostrowska-Leśko, M., Dudka, J., Tkaczyk‐Wlizło, A., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11041183 · Cited by 6
Malek, G., Dwyer, M. A., & McDonnell, D. P. (2011) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-0631-0_8 · Cited by 6
Mechanisms of Oxidative Stress in Retinal Injury
Brantley, M. A., & Sternberg, P. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4557-0737-9.00022-9 · Cited by 8
Self-citationTracing global progress: two decades of age-related macular degeneration research
Yuan, L., Li, L., Yuan, X., & 苑晓勇 (2025) · International Journal of Ophthalmology · doi:10.18240/ijo.2025.05.20 · Cited by 4
Ashique, S., Kumar, S., Hussain, A., Farid, A., Mishra, N., & Garg, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13587-3.00010-2 · Cited by 3
Mitochondrial Genetics of Retinal Disease
Kenney, M. C., Ferrington, D. A., & Udar, N. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4557-0737-9.00032-1 · Cited by 3
Review of Emerging Treatments for Age-Related Macular Degeneration
Zarbin, M. A., & Rosenfeld, P. J. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-606-7_1 · Cited by 3
Udar, N., Atilano, S., Boyer, D., Chwa, M., Memarzadeh, M., Langberg, J., Ab, N., Hertzog, D., & Kenney, M. C. (2017) · Biomedical Genetics and Genomics · doi:10.15761/bgg.1000133 · Cited by 2
Genetics of Age-Related Maculopathy
Fafowora, O. F., & Gorin, M. B. (2012) · Oxford University Press eBooks · doi:10.1093/med/9780195326147.003.0037 · Cited by 2
Oxidative Stress and Systemic Changes in Age-Related Macular Degeneration
Brantley, M. A., Osborn, M. P., Cai, J., & Sternberg, P. (2012) · Humana Press eBooks · doi:10.1007/978-1-61779-606-7_18 · Cited by 2
Self-citationINVESTIGATION OF LEVEL OF SERUM INTERLEUKİN 17 IN AGE-RELATED MACULAR DEGENERATİON
ASLAN, H. T., & Ateş, Ö. (2022) · Sabuncuoglu Serefeddin Health Sciences · doi:10.55895/sshs.1145995 · Cited by 2
Collins, M., & Pearce, B. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10394-6 · Cited by 1
Liu, X., Zhang, M., & Wang, Z. (2026) · Experimental Biology and Medicine · doi:10.3389/ebm.2026.11128 · Cited by 1
Current and future strategies for nonexudative age-related macular degeneration
Grisanti, S., Lüke, J., Lüeke, M., Rudolf, M., & Peters, S. (2011) · Expert Review of Ophthalmology · doi:10.1586/eop.11.26 · Cited by 1
Genetic Basis of Age-related Macular Degeneration
Othman, M., Branham, K. E. H., & Heckenlively, J. R. (2011) · touchREVIEWS in Ophthalmology · doi:10.17925/usor.2011.04.02.119 · Cited by 1
Genetic markers for age-related macular degeneration
Wong, C. W., & Cheng, C. (2014) · doi:10.2217/fmeb2013.13.255 · Cited by 1
Metadata
- Authors
- Canter, J. A., Olson, L. M., Spencer, K., Schnetz-Boutaud, N., Anderson, B., Hauser, M. A., Schmidt, S., Postel, E. A., Agarwal, A., Pericak-Vance, M. A., Sternberg, P., & Haines, J. L.
- Affiliations
- Vanderbilt University Medical Center (US)
- Duke Medical Center (US)
- Corresponding author
- Canter, Jeffrey A.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2008-05-07
- Volume
- 3
- Issue
- 5
- Pages
- e2091
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC2330085
- OpenAlex
- W1976102972
- Cited by
- 110
- References
- 22
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 6 · 2019: 5 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 12 · 2013: 7 · 2012: 13
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- DukeSpace (Duke University) (submittedVersion, cc-by-nc-nd)
- Funders
- Vanderbilt University (M01 RR00095)
- Vanderbilt University Medical Center
- National Eye Institute (R01EY012118, U10EY012118, EY12118)
- National Center for Research Resources (M01RR000095, M01-RR-00095)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- age-related macular degeneration, mitochondrial DNA polymorphism, genetic susceptibility, non-synonymous variants, case-control association, age-matched controls, complement factor H, LOC387715, apolipoprotein E, nuclear polymorphism
- MeSH terms
- Adenine, Aged, Aging, Apolipoproteins E, DNA, Mitochondrial, Female, Fluorescein Angiography, Guanine, Humans, Macular Degeneration, Male, Middle Aged, Reference Values, Genome, DNA Primers, Polymorphism, Single Nucleotide, White People
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
