The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
A Unique Dual Activity Amino Acid Hydroxylase in Toxoplasma gondii
Open accessAbstract
The genome of the protozoan parasite Toxoplasma gondii was found to contain two genes encoding tyrosine hydroxylase; that produces L-DOPA. The encoded enzymes metabolize phenylalanine as well as tyrosine with substrate preference for tyrosine. Thus the enzymes catabolize phenylalanine to tyrosine and tyrosine to L-DOPA. The catalytic domain descriptive of this class of enzymes is conserved with the parasite enzyme and exhibits similar kinetic properties to metazoan tyrosine hydroxylases, but contains a unique N-terminal extension with a signal sequence motif. One of the genes, TgAaaH1, is constitutively expressed while the other gene, TgAaaH2, is induced during formation of the bradyzoites of the cyst stages of the life cycle. This is the first description of an aromatic amino acid hydroxylase in an apicomplexan parasite. Extensive searching of apicomplexan genome sequences revealed an ortholog in Neospora caninum but not in Eimeria, Cryptosporidium, Theileria, or Plasmodium. Possible role(s) of these bi-functional enzymes during host infection are discussed.
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The Neurotropic Parasite Toxoplasma Gondii Increases Dopamine Metabolism
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Self-citationToxoplasma gondii and Other Risk Factors for Schizophrenia: An Update
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Brundin, L., Bryleva, E. Y., & Thirtamara Rajamani, K. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.116 · Cited by 257
“Moreover, the T. gondii genome encodes for tyrosine hydroxylase, a rate-limiting enzyme in the synthesis of dopamine, wherein it catalyzes the conversion of tyrosine into L-DOPA (Gaskell et al , 2009).”
Cook, T. B., Brenner, L. A., Cloninger, C. R., Langenberg, P., Igbide, A., Giegling, I., Hartmann, A. M., Konte, B., Friedl, M., Brundin, L., et al. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2014.09.019 · Cited by 122
Peng, X., Brenner, L. A., Mathai, A. J., Cook, T. B., Fuchs, D., Postolache, N., Groer, M. W., Pandey, J. P., Mohyuddin, F., Giegling, I., et al. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.03.045 · Cited by 16
Metadata
- Authors
- Gaskell, E. A., Smith, J. E., Pinney, J. W., Westhead, D. R., & McConkey, G. A.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2009-03-11
- Volume
- 4
- Issue
- 3
- Pages
- e4801
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2027308346
- Cited by
- 301
- References
- 54
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- gold
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