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LRP1 Regulates Architecture of the Vascular Wall by Controlling PDGFRβ-Dependent Phosphatidylinositol 3-Kinase Activation

Zhou, Li, Takayama, Yoshiharu, Boucher, Philippe, Tallquist, Michelle D., Herz, Joachim·2009·PLoS ONE
DOI 10.1371/journal.pone.0006922PMC PMC2734324
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  • Actin polymerization is impaired in LRP1-deficient cells.

    “Consistent with a LRP1-mediated signaling function, actin polymerization, which is critical for macropinocytosis and Aβ uptake (Mandrekar et al., 2009), is impaired in LRP1-deficient cells (Zhou et al., 2009).”

    From Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-β Uptake (2011) · cites this paper as Zhou et al., 2009

    The Results section on actin disorganization (page unavailable) reports disrupted actin organization in LRP1-deficient vascular smooth muscle cells. It does not report impaired actin polymerization, and its finding is limited to smooth muscle cells rather than LRP1-deficient cells generally. (LLM, conf=0.86)

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Research works printed but not linked: 37

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Metadata

Authors
Zhou, L., Takayama, Y., Boucher, P., Tallquist, M. D., & Herz, J.
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2009-09-09
Volume
4
Issue
9
Pages
e6922
ISSN
1932-6203
DOI
10.1371/journal.pone.0006922
PMC
PMC2734324
Cited by
71
References
0
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (unspecified)

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