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S100a9 Knockdown Decreases the Memory Impairment and the Neuropathology in Tg2576 Mice, AD Animal Model
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S100A9 up-regulated IL-1beta, TNF and iNOS in a microglia cell line.
“One of the proteins in this discriminating cluster, S100A9 up-regulated IL-1beta, TNF and iNOS in microglia cell line (71).”
From Absence of miRNA-146a Differentially Alters Microglia Function and Proteome (2020) · cites this paper as [71]
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Cites
Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability
Dahlgren, K. N., Manelli, A. M., Stine, W. B., Baker, L. K., Krafft, G. A., & LaDu, M. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201750200 · Cited by 1,452
Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice
Hickman, S. E., Allison, E. K., & El Khoury, J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0616-08.2008 · Cited by 1,329 · cited 1×
“A recent report showed that microglia in the brains of aged AD mice became dysfunctional in terms of Ab clearance, and expressions of their Ab-binding receptors and Ab-degrading enzymes were significantly reduced; however, their ability to produce proinflammatory cytokines was maintained [34].”
Kawarabayashi, T., Younkin, L. H., Saido, T. C., Shoji, M., Ashe, K. H., & Younkin, S. G. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00372.2001 · Cited by 1,053 · cited 2×
“APPswe Tg2576 mice were obtained from Taconic Farms (Germantown, NY) and were bred by mating male mice with C57B16/SJL F1 females, as recommended by the suppliers and as described by others [33].”
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Research works printed but not linked: 32
- [1]Selkoe DJ 2001 Alzheimer's disease: Genes, proteins, and therapy. Physiological Reviews 81 741 766 11274343
- [2]Kar S Slowikowski SPM Westaway D Mount HTJ 2004 Interactions between beta-amyloid and central cholinergic neurons: implications for Alzheimer's disease. Journal of Psychiatry & Neuroscience 29 427 441 15644984 PMC524960
- [3]Selkoe DJ 2002 Alzheimer's disease is a synaptic failure. Science 298 789 791 12399581
- [4]Lue LF Brachova L Civin WH Rogers J 1996 Inflammation, A beta deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration. J Neuropathol Exp Neurol 55 1083 1088 8858005
- [5]Hoozemans JJ Veerhuis R Rozemuller JM Eikelenboom P 2006 Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology. Int J Dev Neurosci 24 157 165 16384684
- [6]Lambourne SL Sellers LA Bush TG Choudhury SK Ernson PC 2005 Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: Evidence for distinct molecular processes underlying tau abnormalities. Molecular and Cellular Biology 25 278 293 15601849 PMC538769
- [7]Kammesheidt A Boyce FM Spanoyannis AF Cummings BJ Ortegon M 1992 DEPOSITION OF BETA/A4 IMMUNOREACTIVITY AND NEURONAL PATHOLOGY IN TRANSGENIC MICE EXPRESSING THE CARBOXYL-TERMINAL FRAGMENT OF THE ALZHEIMER AMYLOID PRECURSOR IN THE BRAIN. Proceedings of the National Academy of Sciences of the United States of America 89 10857 10861 1438289 PMC50441
- [8]Nalbantoglu J TiradoSantiago G Lahsaini A Poirier J Goncalves O 1997 Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature 387 500 505 9168112
- [9]Abe M Umehara F Kubota R Moritoyo T Izumo S 1999 Activation of macrophages microglia with the calcium-binding proteins MRP14 and MRP8 is related to the lesional activities in the spinal cord of HTLV-I associated myelopathy. Journal of Neurology 246 358 364 10399866
- [10]Gebhardt C Nemeth J Angel P Hess J 2006 S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol 72 1622 1631 16846592
- [11]Walker DG Link J Lue LF Dalsing-Hernandez JE Boyes BE 2006 Gene expression changes by amyloid beta peptide-stimulated human postmortem brain microglia identify activation of multiple inflammatory processes. J Leukoc Biol 79 596 610 16365156
- [12]Hermani A De Servi B Medunjanin S Tessier PA Mayer D 2006 S100A8 and S100A9 activate MAP kinase and NF-kappaB signaling pathways and trigger translocation of RAGE in human prostate cancer cells. Exp Cell Res 312 184 197 16297907
- [13]Zimmer DB Cornwall EH Landar A Song W 1995 THE S100 PROTEIN FAMILY - HISTORY, FUNCTION, AND EXPRESSION. Brain Research Bulletin 37 417 429 7620916
- [14]Postler E Lehr A Schluesener H Meyermann R 1997 Expression of the S-100 proteins MRP-8 and -14 in ischemic brain lesions. Glia 19 27 34 8989565
- [15]Engel S Schluesener H Mittelbronn M Seid K Adjodah D 2000 Dynamics of microglial activation after human traumatic brain injury are revealed by delayed expression of macrophage-related proteins MRP8 and MRP14. Acta Neuropathol 100 313 322 10965802
- [16]Shepherd CE Goyette J Utter V Rahimi F Yang Z 2006 Inflammatory S100A9 and S100A12 proteins in Alzheimer's disease. Neurobiology of Aging 27 1554 1563 16253391
- [17]Zimmer DB Chaplin J Baldwin A Rast M 2005 S100-mediated signal transduction in the nervous system and neurological diseases. Cellular and Molecular Biology 51 201 214 16171556
- [18]Suh YH Checler F 2002 Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease. Pharmacol Rev 54 469 525 12223532
- [19]Chang KA Kim HS Ha TY Ha JW Shin KY 2006 Phosphorylation of amyloid precursor protein (APP) at Thr668 regulates the nuclear translocation of the APP intracellular domain and induces neurodegeneration. Mol Cell Biol 26 4327 4338 16705182 PMC1489099
- [20]Chang KA Suh YH 2005 Pathophysiological roles of amyloidogenic carboxy-terminal fragments of the beta-amyloid precursor protein in Alzheimer's disease. J Pharmacol Sci 97 461 471 15821343
- [21]Kim HS Kim EM Lee JP Park CH Kim S 2003 C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3 beta expression. Faseb Journal 17 1951 + 12923068
- [22]Westerman MA Cooper-Blacketer D Mariash A Kotilinek L Kawarabayashi T 2002 The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci 22 1858 1867 11880515 PMC6758862
- [23]Hsiao K Chapman P Nilsen S Eckman C Harigaya Y 1996 Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274 99 102 8810256
- [24]Mariggio MA Fulle S Calissano P Nicoletti I Fano G 1994 The brain protein S-100ab induces apoptosis in PC12 cells. Neuroscience 60 29 35 7519760
- [25]Hoffmann A Kann O Ohlemeyer C Hanisch UK Kettenmann H 2003 Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): suppression of receptor-evoked calcium signaling and control of release function. J Neurosci 23 4410 4419 12805281 PMC6740788
- [26]Kerkhoff C Hofmann HA Vormoor J Melkonyan H Roth J 2002 Binding of two nuclear complexes to a novel regulatory element within the human S100A9 promoter drives the S100A9 gene expression. J Biol Chem 277 41879 41887 12167632
- [27]Kuruto-Niwa R Nakamura M Takeishi K Nozawa R 1998 Transcriptional regulation by C/EBP alpha and -beta in the expression of the gene for the MRP14 myeloid calcium binding protein. Cell Struct Funct 23 109 118 9706399
- [28]Cao X Sudhof TC 2001 A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science 293 115 120 11441186
- [29]Bararia D Trivedi AK Zada AA Greif PA Mulaw MA 2008 Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha. Leukemia 22 800 807 18239623
- [30]Tong L Thornton PL Balazs R Cotman CW 2001 Beta -amyloid-(1–42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival Is not compromised. J Biol Chem 276 17301 17306 11278679
- [31]Reese LC Zhang W Dineley KT Kayed R Taglialatela G 2008 Selective induction of calcineurin activity and signaling by oligomeric amyloid beta. Aging Cell 7 824 835 18782350 PMC2954114
- [32]Farber K Kettenmann H 2006 Functional role of calcium signals for microglial function. Glia 54 656 665 17006894
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Prokop, S., Miller, K. R., & Heppner, F. L. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1182-x · Cited by 291
Danger-associated molecular patterns in Alzheimer’s disease
Venegas, C., & Heneka, M. T. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.3mr0416-204r · Cited by 236
Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease
Cristóvão, J. S., Santos, R., & Gomes, C. M. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/9812178 · Cited by 146
Robust shifts in S100a9 expression with aging: A novel mechanism for chronic inflammation
Swindell, W. R., Johnston, A., Xing, X., Little, A., Robichaud, P., Voorhees, J. J., Fisher, G., & Gudjonsson, J. E. (2013) · Scientific Reports · doi:10.1038/srep01215 · Cited by 124
Absence of miRNA-146a Differentially Alters Microglia Function and Proteome
Martin, N. A., Hyrlov, K. H., Elkjaer, M. L., Thygesen, E. K., Wlodarczyk, A., Elbaek, K. J., Aboo, C., Okarmus, J., Benedikz, E., Reynolds, R., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01110 · Cited by 36
Metadata
- Authors
- Ha, T.-Y., Chang, K.-A., Kim, J. A., Kim, H.-S., Kim, S., Chong, Y. H., & Suh, Y.-H.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2010-01-21
- Volume
- 5
- Issue
- 1
- Pages
- e8840
- ISSN
- 1932-6203
- PMC
- PMC2809116
- Cited by
- 73
- References
- 3
- Language
- en
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