Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer’s Disease

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RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

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Natural oligomers of the amyloid-β protein specifically disrupt cognitive function

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Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

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Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

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RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

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Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

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Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

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Functions of S100 Proteins

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The metallobiology of Alzheimer's disease

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The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

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Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

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The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

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Neurotoxicity of Amyloid  -Protein: Synaptic and Network Dysfunction

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Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease: A Pilot Phase 2 Clinical Trial

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Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity

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Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

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Early Aβ accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain

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Characterization of Copper Interactions with Alzheimer Amyloid β Peptides: Identification of an Attomolar‐Affinity Copper Binding Site on Amyloid β1‐42

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Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with β-amyloid deposits in Alzheimer’s disease

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Biological metals and metal-targeting compounds in major neurodegenerative diseases

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Alzheimer’s Disease Genetics: From the Bench to the Clinic

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A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains

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PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

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The Janus face of glial-derived S100B: Beneficial and detrimental functions in the brain

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Redox-active iron mediates amyloid-β toxicity

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Alzheimer's disease, metal ions and metal homeostatic therapy

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Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

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The Revitalized Tau Hypothesis on Alzheimer's Disease

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Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease

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Granular Tau Oligomers as Intermediates of Tau Filaments

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Study of the localization of iron, ferritin, and hemosiderin in Alzheimer’s disease hippocampus by analytical microscopy at the subcellular level

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Copper and Oxidative Stress in the Pathogenesis of Alzheimer’s Disease

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Physiological roles for amyloid β peptides

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Role of RAGE in Alzheimer’s Disease

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Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation

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Structure of the Alzheimer's Disease Amyloid Precursor Protein Copper Binding Domain

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Lost after translation: missorting of Tau protein and consequences for Alzheimer disease

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Elevated cortical zinc in Alzheimer disease

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Increased Iron Levels and Decreased Tissue Integrity in Hippocampus of Alzheimer’s Disease Detected in vivo with Magnetic Resonance Imaging

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The role of metallobiology and amyloid-β peptides in Alzheimer's disease

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Genetics of familial and sporadic Alzheimer s disease

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The Production of Amyloid β Peptide Is a Critical Requirement for the Viability of Central Neurons

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Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease

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New Insights on How Metals Disrupt Amyloid β-Aggregation and Their Effects on Amyloid-β Cytotoxicity

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Metal Ions Differentially Influence the Aggregation and Deposition of Alzheimer's β-Amyloid on a Solid Template

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Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease.

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Molecular anatomy of the postsynaptic density.

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Amyloid precursor protein (APP) and the biology of proteolytic processing: relevance to Alzheimer’s disease

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Review article What causes alzheimer’s disease?

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The Alzheimer's Disease Amyloid Precursor Protein Modulates Copper-Induced Toxicity and Oxidative Stress in Primary Neuronal Cultures

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Progressive accumulation of amyloid‐ β oligomers in Alzheimer’s disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

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Iron Promotes the Toxicity of Amyloid β Peptide by Impeding Its Ordered Aggregation

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Zinc-Amyloid β Interactions on a Millisecond Time-Scale Stabilize Non-fibrillar Alzheimer-Related Species

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Pro-Inflammatory S100A8 and S100A9 Proteins: Self-Assembly into Multifunctional Native and Amyloid Complexes

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A role for tau at the synapse in Alzheimer’s disease pathogenesis

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Redox Reactions of Copper Complexes Formed with Different β-Amyloid Peptides and Their Neuropathalogical Relevance

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Distinct Effects of Zn2+, Cu2+, Fe3+, and Al3+ on Amyloid-β Stability, Oligomerization, and Aggregation

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Molecular-Level Examination of Cu2+ Binding Structure for Amyloid Fibrils of 40-Residue Alzheimer’s β by Solid-State NMR Spectroscopy

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Substoichiometric Levels of Cu2+ Ions Accelerate the Kinetics of Fiber Formation and Promote Cell Toxicity of Amyloid-β from Alzheimer Disease

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Concentration Dependent Cu2+Induced Aggregation and Dityrosine Formation of the Alzheimer's Disease Amyloid-β Peptide

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Metal swap between Zn7-metallothionein-3 and amyloid-β–Cu protects against amyloid-β toxicity

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Low Micromolar Zinc Accelerates the Fibrillization of Human Tau via Bridging of Cys-291 and Cys-322

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Metal ions as modulators of protein conformation and misfolding in neurodegeneration

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Zn(II)‐ and Cu(II)‐induced non‐fibrillar aggregates of amyloid‐β (1–42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators

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Metallothionein III is reduced in Alzheimer’s disease

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The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease

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Are amyloid‐degrading enzymes viable therapeutic targets in Alzheimer’s disease?

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Metals and Alzheimer’s Disease: How Far Have We Come in the Clinic?

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Genetic and Epigenetic Etiology Underlying Autism Spectrum Disorder

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Role of metals in Alzheimer’s disease

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Glycogen Synthase Kinase 3β: A New Gold Rush in Anti-Alzheimer’s Disease Multitarget Drug Discovery?: Miniperspective

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Copper-Targeting Approaches in Alzheimer’s Disease: How To Improve the Fallouts Obtained from in Vitro Studies

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Systemic toxicity eliciting metal ion levels from metallic implants and orthopedic devices – A mini review

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Metal Binding of Alzheimer’s Amyloid-β and Its Effect on Peptide Self-Assembly

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Zinc and Central Nervous System Disorders

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Noxious Iron–Calcium Connections in Neurodegeneration

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The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation

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Dietary Habits, Selenium, Copper, Zinc and Total Antioxidant Status in Serum in Relation to Cognitive Functions of Patients with Alzheimer’s Disease

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Divalent Cations: A Molecular Glue for Protein Materials

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Iron and manganese-related CNS toxicity: mechanisms, diagnosis and treatment

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Hepcidin and its therapeutic potential in neurodegenerative disorders

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Iron Pathophysiology in Alzheimer’s Diseases

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Crosstalk between zinc and free fatty acids in plasma

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Molecular Level Insight Into the Benefit of Myricetin and Dihydromyricetin Uptake in Patients With Alzheimer’s Diseases

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Thermodynamic analysis of amyloid fibril structures reveals a common framework for stability in amyloid polymorphs

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Moderate nutrient restriction of beef heifers alters expression of genes associated with tissue metabolism, accretion, and function in fetal liver, muscle, and cerebrum by day 50 of gestation1

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Subcellular Localization of Copper—Cellular Bioimaging with Focus on Neurological Disorders

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Recent advancement in therapeutic strategies for Alzheimer’s disease: Insights from clinical trials

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Distribution and Relative Abundance of S100 Proteins in the Brain of the APP23 Alzheimer’s Disease Model Mice

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Trace Elements in Alzheimer’s Disease and Dementia: The Current State of Knowledge

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Characterizing effects of excess copper levels in a human astrocytic cell line with focus on oxidative stress markers

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Exploring the therapeutic potential of natural compounds for Alzheimer's disease: Mechanisms of action and pharmacological properties

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Trace metal concentrations in hair and nails from Alzheimer’s disease patients: Relations with clinical severity

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Biochemical CuSO4 Toxicity in Drosophila melanogaster Depends on Sex and Developmental Stage of Exposure

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The neuritic plaque in Alzheimer's disease: perivascular degeneration of neuronal processes

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Challenges and Opportunities of Metal Chelation Therapy in Trace Metals Overload-Induced Alzheimer’s Disease

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Molecular Mechanisms of Curcumin in Neuroinflammatory Disorders: A Mini Review of Current Evidences

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Zinc Binding to Tau Influences Aggregation Kinetics and Oligomer Distribution

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Zinc Binding to S100B Affords Regulation of Trace Metal Homeostasis and Excitotoxicity in the Brain

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Toward a Unified Framework in Molecular Neurobiology of Alzheimer’s Disease: Revisiting the Pathophysiological Hypotheses

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A Mechanistic Evaluation of Antioxidant Nutraceuticals on Their Potential against Age-Associated Neurodegenerative Diseases

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Stimuli-controllable iron oxide nanoparticle assemblies: Design, manipulation and bio-applications

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X-ray Fluorescence Nanotomography of Single Bacteria with a Sub-15 nm Beam

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Folding of copper proteins: role of the metal?

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Size and Shape of Amyloid Fibrils Induced by Ganglioside Nanoclusters: Role of Sialyl Oligosaccharide in Fibril Formation

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Glial S100A6 Degrades β-amyloid Aggregation through Targeting Competition with Zinc Ions

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Biofabrication of functional protein nanoparticles through simple His-tag engineering

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Rebalancing metal dyshomeostasis for Alzheimer’s disease therapy

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Examining the homeostatic distribution of metals and Zn isotopes in Göttingen minipigs

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Mechanistic Effect of Heavy Metals in Neurological Disorder and Brain Cancer

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Sortilin Fragments Deposit at Senile Plaques in Human Cerebrum

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Azo-Stilbene and Pyridine–Amine Hybrid Multifunctional Molecules to Target Metal-Mediated Neurotoxicity and Amyloid-β Aggregation in Alzheimer’s Disease

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Innovative approaches to Alzheimer's therapy: Harnessing the power of heterocycles, oxidative stress management, and nanomaterial drug delivery system

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Effects of Intrinsic and Extrinsic Factors on Aggregation of Physiologically Important Intrinsically Disordered Proteins

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Acetylcholinesterase inhibitors in Alzheimer's disease influence Zinc and Copper homeostasis

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The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment

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Gene-expression profiling of individuals resilient to Alzheimer's disease reveals higher expression of genes related to metallothionein and mitochondrial processes and no changes in the unfolded protein response

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Peumus boldus attenuates copper-induced toxicity in Drosophila melanogaster

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The Role of Trace Metals in Alzheimer’s Disease

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Cholinesterase inhibitory activity, antioxidant properties, and phytochemical composition ofChlorococcumsp. extracts

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Metallomics for Alzheimer's disease treatment: Use of new generation of chelators combining metal-cation binding and transport properties

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Hydroxy-substituted trans -cinnamoyl derivatives as multifunctional tools in the context of Alzheimer's disease

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The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells

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The S100B Alarmin Is a Dual-Function Chaperone Suppressing Amyloid-β Oligomerization through Combined Zinc Chelation and Inhibition of Protein Aggregation

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Urinary Metal Levels, Cognitive Test Performance, and Dementia in the Multi-Ethnic Study of Atherosclerosis

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Design, synthesis and biological evaluation of potential anti-AD hybrids with monoamine oxidase B inhibitory and iron-chelating effects

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Metallomics Applied to the Study of Neurodegenerative and Mental Diseases

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Anti‐IgLON5 Disease Responsive to Immunotherapy: A Case Report with an Abnormal MRI

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Unravelling neurological disorders through metallomics-based approaches

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A Review: Pharmacological and herbal remedies in The Management of Neurodegenerative disorder (Alzheimer’s)

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Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study

Jang, D., Dou, J., Koubek, E. J., Teener, S. J., Zhao, L., Bakulski, K. M., Mukherjee, B., Batterman, S., Feldman, E. L., & Goutman, S. A. (2024) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2024-333978 · Cited by 17 · see citing works

Biophysical and Spectroscopic Methods for Monitoring Protein Misfolding and Amyloid Aggregation

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Iron Dysregulation in Alzheimer’s Disease: LA-ICP-MS Bioimaging of the Distribution of Iron and Ferroportin in the CA1 Region of the Human Hippocampus

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Early 17β-estradiol treatment reduces seizures but not abnormal behaviour in mice with expanded polyalanine tracts in the Aristaless related homeobox gene (ARX)

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Design, synthesis and in-vitro evaluation of fluorinated triazoles as multi-target directed ligands for Alzheimer disease

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A Mathematical Model for Amyloid-𝜷 Aggregation in the Presence of Metal Ions: A Timescale Analysis for the Progress of Alzheimer Disease

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From Small Peptides to Large Proteins against Alzheimer’sDisease

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S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation

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Synthesis, molecular docking and spectroscopic studies of pyridoxine carbamates as metal chelator

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Vitamin A Reduces the Mortality of Animals with Induced Liver Fibrosis by Providing a Multi-level Body Defense System

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Diet-Induced Obesity Disrupts Trace Element Homeostasis and Gene Expression in the Olfactory Bulb

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Cu(I) chelators: Useful tools to reveal and control Cu(I) homeostasis and toxicity

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Exploring the K isotope composition of Göttingen minipig brain regions, and implications for Alzheimer's disease

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Manganese-induced neurotoxicity in cerebellar granule neurons due to perturbation of cell network pathways with potential implications for neurodegenerative disorders

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Alzheimer's Disease: Related Targets, Synthesis of Available Drugs, Bioactive Compounds Under Development and Promising Results Obtained from Multi-target Approaches

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Recent Advances in the Development of Metal-Glycoconjugates for Medicinal Applications

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Potential role of herbal plants and beta sitosterol as a bioactive constituent in circumventing Alzheimer’s Disease

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Aging-Related Protein Alterations in the Brain

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