Products of Vitamin D3 or 7-Dehydrocholesterol Metabolism by Cytochrome P450scc Show Anti-Leukemia Effects, Having Low or Absent Calcemic Activity

Slominski, Andrzej T.; Janjetovic, Zorica; Fuller, Brian E.; Zmijewski, Michal A.; Tuckey, Robert C.; Nguyen, Minh N.; Sweatman, Trevor; Li, Wei; Zjawiony, Jordan; Miller, Duane; Chen, Tai C.; Lozanski, Gerard; Holick, Michael F.

doi:10.1371/journal.pone.0009907

Products of Vitamin D3 or 7-Dehydrocholesterol Metabolism by Cytochrome P450scc Show Anti-Leukemia Effects, Having Low or Absent Calcemic Activity

Background Cytochrome P450scc metabolizes vitamin D3 to 20-hydroxyvitamin D3 (20(OH)D3) and 20,23(OH)2D3, as well as 1-hydroxyvitamin D3 to 1α,20-dihydroxyvitamin D3 (1,20(OH)2D3). It also cleaves the side chain of 7-dehydrocholesterol producing 7-dehydropregnenolone (7DHP), which can be transfor…