Tuckey, Robert C.

Steroidogenesis in the skin: Implications for local immune functions

Slominski, A., Zbytek, B., Nikolakis, G., Manna, P. R., Skobowiat, C., Zmijewski, M., Li, W., Janjetovic, Z., Postlethwaite, A., Zouboulis, C. C., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology

Adrenal Hormones and DisordersDermatology and Skin Diseases

Cited by 369

Progesterone synthesis by the human placenta

Tuckey, R. C. (2005) · Placenta

Pregnancy and preeclampsia studiesSteroid Chemistry and Biochemistry

Cited by 312

Novel activities of CYP11A1 and their potential physiological significance

Slominski, A. T., Li, W., Kim, T.-K., Semak, I., Wang, J., Zjawiony, J. K., & Tuckey, R. C. (2015) · The Journal of Steroid Biochemistry and Molecular Biology

Steroid Chemistry and BiochemistryCholesterol and Lipid Metabolism

Cited by 292

Differential expression of HPA axis homolog in the skin

Slominski, A., Wortsman, J., Tuckey, R. C., & Paus, R. (2007) · Molecular and Cellular Endocrinology

Stress Responses and CortisolAdrenal Hormones and Disorders

Cited by 279

Cutaneous hypothalamic–pituitary–adrenal axis homolog: regulation by ultraviolet radiation

Skobowiat, C., Dowdy, J. C., Sayre, R. M., Tuckey, R. C., & Slominski, A. (2011) · American Journal of Physiology-Endocrinology and Metabolism

Skin Protection and AgingStress Responses and Cortisol

Cited by 269

In vivo evidence for a novel pathway of vitamin D 3 metabolism initiated by P450scc and modified by CYP27B1

Slominski, A. T., Kim, T., Shehabi, H. Z., Semak, I., Tang, E. K. Y., Nguyen, M. N., Benson, H. A. E., Korik, E., Janjetovic, Z., Chen, J., et al. (2012) · The FASEB Journal

Vitamin D Research StudiesSteroid Chemistry and Biochemistry

Cited by 266

The serum vitamin D metabolome: what we know and what is still to discover

Tuckey, R. C., Cheng, C. Y. S., & Slominski, A. T. (2019) · The Journal of Steroid Biochemistry and Molecular Biology

Vitamin D Research StudiesMetabolomics and Mass Spectrometry Studies

Cited by 245

The role of CYP11A1 in the production of vitamin D metabolites and their role in the regulation of epidermal functions

Slominski, A. T., Kim, T.-K., Li, W., Yi, A.-K., Postlethwaite, A., & Tuckey, R. C. (2014) · The Journal of Steroid Biochemistry and Molecular Biology

Vitamin D Research StudiesDermatology and Skin Diseases

Cited by 170

Extra-adrenal glucocorticoid biosynthesis: implications for autoimmune and inflammatory disorders

Slominski, R. M., Tuckey, R. C., Manna, P. R., Jetten, A. M., Postlethwaite, A., Raman, C., & Slominski, A. T. (2020) · Genes & Immunity

Adrenal Hormones and DisordersStress Responses and Cortisol

Cited by 155

The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism

Slominski, A., Semak, I., Zjawiony, J., Wortsman, J., Li, W., Szczesniewski, A., & Tuckey, R. C. (2005) · The FEBS Journal

Vitamin D Research StudiesSteroid Chemistry and Biochemistry

Cited by 155

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity

Slominski, A. T., Janjetovic, Z., Fuller, B. E., Zmijewski, M. A., Tuckey, R. C., Nguyen, M. N., Sweatman, T., Li, W., Zjawiony, J., Miller, D., et al. (2010) · PLoS ONE

Vitamin D Research StudiesRetinoids in leukemia and cellular processes

Cited by 149

Protective Effects of Novel Derivatives of Vitamin D3 and Lumisterol Against UVB-Induced Damage in Human Keratinocytes Involve Activation of Nrf2 and P53 Defense Mechanisms

Chaiprasongsuk, A., Janjetovic, Z., Kim, T.-K., Jarrett, S. G., D'Orazio, J. A., Holick, M. F., Tang, E. K. Y., Tuckey, R. C., Panich, U., Li, W., et al. (2019) · Redox Biology

Skin Protection and AgingVitamin D Research Studies

Cited by 146

Endogenously produced nonclassical vitamin D hydroxy-metabolites act as “biased” agonists on VDR and inverse agonists on RORα and RORγ

Slominski, A. T., Kim, T.-K., Hobrath, J. V., Oak, A. S. W., Tang, E. K. Y., Tieu, E. W., Li, W., Tuckey, R. C., & Jetten, A. M. (2017) · The Journal of Steroid Biochemistry and Molecular Biology

Vitamin D Research StudiesPsoriasis: Treatment and Pathogenesis

Cited by 143

Vitamin D signaling and melanoma: role of vitamin D and its receptors in melanoma progression and management

Slominski, A. T., Brożyna, A. A., Zmijewski, M. A., Jóźwicki, W., Jetten, A. M., Mason, R. S., Tuckey, R. C., & Elmets, C. A. (2017) · Laboratory Investigation

Vitamin D Research StudiesCutaneous Melanoma Detection and Management

Cited by 136

20-Hydroxycholecalciferol, Product of Vitamin D3 Hydroxylation by P450scc, Decreases NF-κB Activity by Increasing IκBα Levels in Human Keratinocytes

Janjetovic, Z., Zmijewski, M. A., Tuckey, R. C., DeLeon, D. A., Nguyen, M. N., Pfeffer, L. M., & Slominski, A. T. (2009) · PLoS ONE

NF-κB Signaling PathwaysVitamin D Research Studies

Cited by 130

20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation

Zbytek, B., Janjetovic, Z., Tuckey, R. C., Zmijewski, M. A., Sweatman, T. W., Jones, E., Nguyen, M. N., & Slominski, A. T. (2008) · Journal of Investigative Dermatology

Vitamin D Research StudiesSkin and Cellular Biology Research

Cited by 118

Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc

Tuckey, R. C., Li, W., Zjawiony, J. K., Zmijewski, M. A., Nguyen, M. N., Sweatman, T., Miller, D., & Slominski, A. (2008) · The FEBS Journal

Vitamin D Research StudiesSteroid Chemistry and Biochemistry

Cited by 118

20-Hydroxyvitamin D2 is a noncalcemic analog of vitamin D with potent antiproliferative and prodifferentiation activities in normal and malignant cells

Slominski, A. T., Kim, T.-K., Janjetovic, Z., Tuckey, R. C., Bieniek, R., Yue, J., Li, W., Chen, J., Nguyen, M. N., Tang, E. K. Y., et al. (2011) · American Journal of Physiology-Cell Physiology

Vitamin D Research StudiesSkin Protection and Aging

Cited by 113

20,23‐dihydroxyvitamin D3, novel P450scc product, stimulates differentiation and inhibits proliferation and NF‐κB activity in human keratinocytes

Janjetovic, Z., Tuckey, R. C., Nguyen, M. N., Thorpe, E. M., & Slominski, A. T. (2010) · Journal of Cellular Physiology

Vitamin D Research StudiesPsoriasis: Treatment and Pathogenesis

Cited by 103

In vivo production of novel vitamin D2 hydroxy-derivatives by human placentas, epidermal keratinocytes Caco-2 colon cells and the adrenal gland

Slominski, A. T., Kim, T.-K., Shehabi, H. Z., Tang, E. K. Y., Benson, H. A. E., Semak, I., Lin, Z., Yates, C. R., Wang, J., Li, W., et al. (2014) · Molecular and Cellular Endocrinology

Vitamin D Research StudiesPharmacogenetics and Drug Metabolism

Cited by 100

An alternative pathway of vitamin D2 metabolism: Cytochrome P450scc (CYP11A1)‐mediated conversion to 20‐hydroxyvitamin D2 and 17,20‐dihydroxyvitamin D2

Slominski, A., Semak, I., Wortsman, J., Zjawiony, J., Li, W., Zbytek, B., & Tuckey, R. C. (2006) · The FEBS Journal

Vitamin D Research StudiesSteroid Chemistry and Biochemistry

Cited by 98

High basal NF-κB activity in nonpigmented melanoma cells is associated with an enhanced sensitivity to vitamin D3 derivatives

Janjetovic, Z., Brozyna, A. A., Tuckey, R. C., Kim, T.-K., Nguyen, M. N., Jozwicki, W., Pfeffer, S. R., Pfeffer, L. M., & Slominski, A. T. (2011) · British Journal of Cancer

NF-κB Signaling PathwaysVitamin D Research Studies

Cited by 91

Sequential metabolism of 7-dehydrocholesterol to steroidal 5, 7-dienes in adrenal glands and its biological implication in the skin

Slominski, A. T., Zmijewski, M. A., Semak, I., Sweatman, T., Janjetovic, Z., Li, W., Zjawiony, J. K., & Tuckey, R. C. (2009) · PLoS ONE

Steroid Chemistry and BiochemistryCholesterol and Lipid Metabolism

Cited by 90

20 S-Hydroxyvitamin D3, Noncalcemic Product of CYP11A1 Action on Vitamin D3, Exhibits Potent Antifibrogenic Activity in Vivo

Slominski, A., Janjetovic, Z., Tuckey, R. C., Nguyen, M. N., Bhattacharya, K. G., Wang, J., Li, W., Jiao, Y., Gu, W., Brown, M., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism

Systemic Sclerosis and Related DiseasesVitamin D Research Studies

Cited by 89