The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Interferon-γ Regulates the Proliferation and Differentiation of Mesenchymal Stem Cells via Activation of Indoleamine 2,3 Dioxygenase (IDO)
Open accessAbstract
The kynurenine pathway (KP) of tryptophan metabolism is linked to antimicrobial activity and modulation of immune responses but its role in stem cell biology is unknown. We show that human and mouse mesenchymal and neural stem cells (MSCs and NSCs) express the complete KP, including indoleamine 2,3 dioxygenase 1 (IDO) and IDO2, that it is highly regulated by type I (IFN-β) and II interferons (IFN-γ), and that its transcriptional modulation depends on the type of interferon, cell type and species. IFN-γ inhibited proliferation and altered human and mouse MSC neural, adipocytic and osteocytic differentiation via the activation of IDO. A functional KP present in MSCs, NSCs and perhaps other stem cell types offers novel therapeutic opportunities for optimisation of stem cell proliferation and differentiation.
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The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments
Bustin, S. A., Benes, V., Garson, J. A., Hellemans, J., Huggett, J., Kubista, M., Mueller, R., Nolan, T., Pfaffl, M. W., Shipley, G. L., et al. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.112797 · Cited by 16,303
Ido expression by dendritic cells: tolerance and tryptophan catabolism
Mellor, A. L., & Munn, D. H. (2004) · Nature Reviews Immunology · doi:10.1038/nri1457 · Cited by 2,341
Cited by
Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine
Vizoso, F., Eiro, N., Cid, S., Schneider, J., & Perez-Fernandez, R. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091852 · Cited by 1,363
Multipotent mesenchymal stromal cells and the innate immune system
Le Blanc, K., & Mougiakakos, D. (2012) · Nature Reviews Immunology · doi:10.1038/nri3209 · Cited by 1,018
Concise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells
Lv, F.-J., Tuan, R. S., Cheung, K. M. C., & Leung, V. Y. L. (2014) · Stem Cells · doi:10.1002/stem.1681 · Cited by 984
Madrigal, M., Rao, K. S., & Riordan, N. H. (2014) · Journal of Translational Medicine · doi:10.1186/s12967-014-0260-8 · Cited by 615
Quinolinic acid, the inescapable neurotoxin
Guillemin, G. J. (2012) · The FEBS Journal · doi:10.1111/j.1742-4658.2012.08485.x · Cited by 595
Metadata
- Authors
- Croitoru-Lamoury, J., Lamoury, F. M. J., Caristo, M., Suzuki, K., Walker, D., Takikawa, O., Taylor, R., & Brew, B. J.
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2011-02-16
- Volume
- 6
- Issue
- 2
- Pages
- e14698
- ISSN
- 1932-6203 (ISSN-L)
- OpenAlex
- W2090815903
- Cited by
- 226
- References
- 2
- FWCI
- 5.20
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Interferon-γ Regulates the Proliferation and Differentiation of Mesenchymal Stem Cells via Activation of Indoleamine 2,3 Dioxygenase (IDO). https://app.cochat.ai/papers/10.1371/journal.pone.0014698
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- Croitoru-Lamoury, J., Lamoury, F. M. J., Caristo, M., Suzuki, K., Walker, D., Takikawa, O., Taylor, R., & Brew, B. J. (2011). Interferon-γ Regulates the Proliferation and Differentiation of Mesenchymal Stem Cells via Activation of Indoleamine 2,3 Dioxygenase (IDO). PLoS ONE. https://doi.org/10.1371/journal.pone.0014698
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