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Cited by 174Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 34 of the 36 references it cites were found in a registry or an index.

Adipocyte hypertrophy, fatty liver, and metabolic risk factors in South Asians: The Molecular Study of Health and Risk in Ethnic Groups (mol-SHARE)

Open access
Anand, Sonia S., Tarnopolsky, Mark A., Rashid, Shirya, Schulze, Karleen M., Desai, Dipika, Mente, Andrew, Rao, Sandy, Yusuf, Salim, Gerstein, Hertzel C., Sharma, Arya M.·2011·PLoS ONE
DOI 10.1371/journal.pone.0022112PMC PMC3145635
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Abstract

OBJECTIVE: We sought to determine if differences in the distribution and characteristics of adipose tissue between South Asians and white Caucasians account for differences in risk factors for cardiovascular disease. RESEARCH DESIGN AND METHODS: We recruited 108 healthy South Asians (36.8 years) and white Caucasians (34.2 years) within three BMI strata. Body composition, adipocyte size, abdominal fat area, and hepatic adiposity were assessed and related to fasting glucose, insulin, lipids and adiponectin. RESULTS: After adjustment for age, sex, and BMI, South Asians compared to white Caucasians had higher ln fasting insulin (mean difference (MD): 0.44; 95% CI: 0.20-0.69), lower HDL cholesterol (md: -0.13; 95% CI:-0.26 to -0.01), and lower adiponectin (md: -2.38; 95% CI: -3.59 to -1.17). South Asians also had more body fat (md: 2.69; 95% CI: 0.70 to 4.69), lower lean muscle mass (md: -3.25; 95%CI: -5.35 to -1.14), increased waist to hip ratio (md: 0.03; 95% CI: 0.01-0.05), less superficial subcutaneous abdominal adipose tissue (md: -2.94; 95% CI: -5.56 to-0.32), more deep/visceral to superficial adipose tissue ratio (md 0.34; 95% CI: 0.02 to 0.65), and more liver fat (md: 7.43%; 95% CI: 2.30 to 12.55%). Adipocyte area was increased in South Asians compared to white Caucasians (md: 64.26; 95% CI: 24.3 to 104.1) units(2). Adjustment for adipocyte area attenuated the ethnic differences in insulin (md: 0.22; 95% CI: -0.07 to 0.51), HDL (md: -0.01; 95% CI: -0.16 to 0.13) and adiponectin (md: -1.11; 95% CI: -2.61 to 0.39). Adjustment for differences in adipocyte area and fat distribution attenuated the ethnic difference in liver fat (md: 5.19; 95% CI: 0.31 to 10.06). CONCLUSION: South Asians have an increased adipocyte area compared to white Caucasians. This difference accounts for the ethnic differences in insulin, HDL cholesterol, adiponectin, and ectopic fat deposition in the liver.

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Figure 1 BMI: Body Mass Index, error bars represent the standard error.
Figure 1 BMI: Body Mass Index, error bars represent the standard error.CC BY · PubMed Central
Figure 2 BMI: Body Mass Index, error bars represent the standard error.
Figure 2 BMI: Body Mass Index, error bars represent the standard error.CC BY · PubMed Central
Figure 3 HDL: High Density Lipoprotein, CRP: C-reactive protein.
Figure 3 HDL: High Density Lipoprotein, CRP: C-reactive protein.CC BY · PubMed Central

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Research works printed but not linked: 2

  1. 2003, Diabetes Atlas Second Edition Executive Summary. Brussels: International Diabetes Federation.
  2. MA Tarnopolsky, 2007, Influence of endurance exercise training and sex on intramyocellular lipid and mitochondrial ultrastructure, substrate use, and mitochondrial enzyme activity., Am J Physiol Regul Integr Comp Physiol, 292, R1271, 10.1152/ajpregu.00472.2006 · DOI · Paper page

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Metadata

Authors
Anand, S. S., Tarnopolsky, M. A., Rashid, S., Schulze, K. M., Desai, D., Mente, A., Rao, S., Yusuf, S., Gerstein, H. C., & Sharma, A. M.
Affiliations
  • Population Health Research Institute (CA)
  • McMaster University (CA)
  • University of Alberta (CA)
Corresponding author
Anand, Sonia S.
ORCID
Venue
PLoS ONE
Publisher
Public Library of Science (PLoS)
Published
2011-07-28
Volume
6
Issue
7
Pages
e22112
ISSN
1932-6203 (ISSN-L)
DOI
10.1371/journal.pone.0022112
PMC
PMC3145635
OpenAlex
W2043632902
Cited by
174
References
36
Citations by year
2026: 8 · 2025: 14 · 2024: 13 · 2023: 11 · 2022: 2 · 2021: 8 · 2020: 13 · 2019: 10 · 2018: 9 · 2017: 13 · 2016: 9 · 2015: 20 · 2014: 19 · 2013: 15 · 2012: 8
FWCI
10.56
Type
journal article
Language
en
Open access
Licence
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Heart and Stroke Foundation of Canada
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords
adipocyte hypertrophy, hepatic steatosis, South Asians, ethnic differences, body fat distribution, visceral adipose tissue, insulin resistance, adiponectin, HDL cholesterol, cardiovascular risk factors, body composition, lean muscle mass, waist-to-hip ratio, adipocyte size, metabolic risk factors, ethnic health disparities
MeSH terms
Adult, Cardiovascular Diseases, Ethnicity, Fatty Liver, Female, Humans, Insulin, Lipids, Male, Obesity, Risk Factors, Adipocytes, White People, Asian People, Waist-Hip Ratio, Adiponectin

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