Cited by 340Gut microbiota and healthGastrointestinal motility and disordersProbiotics and Fermented Foods

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Intestinal Microbiota in Healthy Adults: Temporal Analysis Reveals Individual and Common Core and Relation to Intestinal Symptoms

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Jalanka-Tuovinen, Jonna, Salonen, Anne, Nikkilä, Janne, Immonen, Outi, Kekkonen, Riina, Lahti, Leo, Palva, Airi, de Vos, Willem M.·2011·PLoS ONE

DOI 10.1371/journal.pone.0023035PMC PMC3145776

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Abstract

BACKGROUND: While our knowledge of the intestinal microbiota during disease is accumulating, basic information of the microbiota in healthy subjects is still scarce. The aim of this study was to characterize the intestinal microbiota of healthy adults and specifically address its temporal stability, core microbiota and relation with intestinal symptoms. We carried out a longitudinal study by following a set of 15 healthy Finnish subjects for seven weeks and regularly assessed their intestinal bacteria and archaea with the Human Intestinal Tract (HIT) Chip, a phylogenetic microarray, in conjunction with qPCR analyses. The health perception and occurrence of intestinal symptoms was recorded by questionnaire at each sampling point. PRINCIPAL FINDINGS: A high overall temporal stability of the microbiota was observed. Five subjects showed transient microbiota destabilization, which correlated not only with the intake of antibiotics but also with overseas travelling and temporary illness, expanding the hitherto known factors affecting the intestinal microbiota. We identified significant correlations between the microbiota and common intestinal symptoms, including abdominal pain and bloating. The most striking finding was the inverse correlation between Bifidobacteria and abdominal pain: subjects who experienced pain had over five-fold less Bifidobacteria compared to those without pain. Finally, a novel computational approach was used to define the common core microbiota, highlighting the role of the analysis depth in finding the phylogenetic core and estimating its size. The in-depth analysis suggested that we share a substantial number of our intestinal phylotypes but as they represent highly variable proportions of the total community, many of them often remain undetected. CONCLUSIONS/SIGNIFICANCE: A global and high-resolution microbiota analysis was carried out to determine the temporal stability, the associations with intestinal symptoms, and the individual and common core microbiota in healthy adults. The findings provide new approaches to define intestinal health and to further characterize the microbial communities inhabiting the human gut.

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Authors: Jalanka-Tuovinen, J., Salonen, A., Nikkilä, J., Immonen, O., Kekkonen, R., Lahti, L., Palva, A., & de Vos, W. M.
Affiliations: University of Helsinki (FI)
Valio (Finland) (FI)
Corresponding author: Salonen, Anne
ORCID: Salonen, Anne
Lahti, Leo
Venue: PLoS ONE
Publisher: Public Library of Science (PLoS)
Published: 2011-07-28
Volume: 6
Issue: 7
Pages: e23035
ISSN: 1932-6203 (ISSN-L)
DOI: 10.1371/journal.pone.0023035
PMC: PMC3145776
OpenAlex: W2157800726
Cited by: 340
References: 75
Citations by year: 2026: 2 · 2025: 7 · 2024: 19 · 2023: 17 · 2022: 23 · 2021: 20 · 2020: 23 · 2019: 19 · 2018: 19 · 2017: 34 · 2016: 32 · 2015: 28 · 2014: 31 · 2013: 44 · 2012: 20
FWCI: 12.61
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (unspecified)
Locations: PLoS ONE (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
Socio-Environmental Systems Modeling (acceptedVersion)
Työväentutkimus Vuosikirja (submittedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Figshare (submittedVersion, cc-by)
Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
Funders: Tekes
Valio
Wageningen University and Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: gut microbiota, healthy adults, temporal stability, core microbiome, intestinal symptoms, abdominal pain, bloating, Bifidobacterium, antibiotics, archaea, gut health
MeSH terms: Adult, Bacteria, DNA, Bacterial, Double-Blind Method, Feces, Female, Humans, Intestinal Diseases, Intestines, Longitudinal Studies, Male, Middle Aged, Phylogeny, RNA, Messenger, RNA, Ribosomal, 16S, Biomarkers, Reverse Transcriptase Polymerase Chain Reaction, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Biodiversity, Metagenome

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Intestinal Microbiota in Healthy Adults: Temporal Analysis Reveals Individual and Common Core and Relation to Intestinal Symptoms

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